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1. |
resistin induces insulin resistance in HepG2 cells at least partly via induction of SOCS-3 expression and reduction of Akt phosphorylation through an AMPK-independent mechanism |
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Data suggest that genistein in combination with capsaicin exerts anti-inflammatory and anticarcinogenic properties through the modulation of AMPK and COX-2 and possibly various mitogen-activated protein kinases synergistically or nonsynergistically. |
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Variants in genes for AMPKalpha2 and AMPKgamma3 were not associated with PCOS or its component traits. |
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Results suggest that the mechanism by which PTP1B regulates adiposity and leptin sensitivity likely involves the coordinated regulation of AMPK in hypothalamus and peripheral tissues. |
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Treatment with globular adiponectin significantly reduced simulated ischemia-reperfusion injury induced apoptosis in WT cardiomyocytes as well as in AMPK-alpha2 dominant negative cardiomyocytes. |
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6. |
Inhibition of de novo purine synthesis in human prostate cells results in ATP depletion, AMPK and p53 activation, and induces senescence. |
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7. |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
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8. |
The phosphorylation of GFAT1 at Ser243 by AMPK has an important role in the regulation of the GFAT1 enzymatic activity. |
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9. |
A novel AMPK-mediated regulatory pathway that regulates PGC-1alpha gene expression. |
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10. |
AMPK alpha2 activity, AMPK alpha2 Thr172 phosphorylation, and ACC-beta Ser222 phosphorylation were increased immediately after exercise. These increases had all returned to basal levels at 3 and 24 h after exercise. |
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11. |
Results demonstrate that AMPK-alpha1 and AMPK-alpha2 activity and fuel selection in skeletal muscle in response to exercise can be manipulated by diet and/or the interactive effects of diet and exercise training. |
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12. |
alpha2 But not alpha1 AMP-activated protein kinase mediates oxidative stress-induced inhibition of retinal pigment epithelium cell phagocytosis of photoreceptor outer segments |
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13. |
genetic variants of LKB1-AMPK-TORC2 pathway components may exert a weak influence on the occurrence of type 2 diabetes in Japanese |
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14. |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
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15. |
Observational study of gene-disease association. (HuGE Navigator) |
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16. |
AA454543 may have a role in progression of hepatocellular carcinoma after partial hepatectomy |
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17. |
results suggest that nuclear translocation of 5' AMP-activated protein kinase might mediate the effects of exercise on skeletal muscle gene and protein expression |
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18. |
LKB1 kinase, which is associated with Peutz-Jeghers cancer-susceptibility syndrome, phosphorylates and activates AMPK in vitro. |
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19. |
data suggest that moderate endurance exercise promotes glucose transport, GLUT4 expression, and insulin sensitivity in skeletal muscle at least partially via activation of the alpha2 isoform of AMPK |
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20. |
AMPK and eEF2 kinase may provide a key link between cellular energy status and the inhibition of protein synthesis, a major consumer of metabolic energy |
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21. |
These data suggest that prolonged hypoxia promotes the expression and functional activation of AMPKalpha2 and VEGF production in glioma cell lines and glioblastoma multiform tumors, thus contributing to tumor survival and angiogenesis in gliomas. |
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22. |
AMPK signaling is not a key regulatory system of muscle substrate combustion during prolonged exercise and marked activation of AMPK via phosphorylation is not sufficient to maintain an elevated ACCbeta Ser(221) phosphorylation during prolonged exercise |
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23. |
AMPK is a novel and critical component of HIF-1 regulation, implying its involvement in vanadate-induced prostate carcinogenesis |
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24. |
Findings indicate that AMPK activation in skeletal muscle during exercise is not sensitive to changes in plasma glucose levels in the normal range. |
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25. |
This study demonstrates that protein content and basal AMPK activity in human skeletal muscle are highly susceptible to endurance exercise training. |
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26. |
Results indicate that AMP-activated protein kinase (AMPK)alpha negatively regulates acetyl-CoA carboxylase activity and hepatic lipid content. |
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27. |
AMPK has a role in the phenobarbital induction of CYP2B gene expression |
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28. |
causes inappropriate AMP kinase activation, which leads to glycogen accumulation and heart conduction system disease when transfected into mice |
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29. |
Acetyl-CoA carboxylase beta phosphorylation is especially sensitive to exercise and tightly coupled to AMPK signaling and that AMPK activation does not depend on AMPK kinase activation during exercise. |
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30. |
AMPK has a major role in the post-transcriptional regulation of VEGF and a potential role in tumor angiogenesis |
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31. |
Overexpression of CaMKKbeta in mammalian cells increases AMPK activity, whereas pharmacological inhibition of CaMKK, or downregulation of CaMKKbeta using RNA interference, almost completely abolishes AMPK activation |
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32. |
There is a significant basal activity and phosphorylation of AMPK in LKB1-deficient cells that can be stimulated by Ca2+ ionophores, and studies using the CaMKK inhibitor STO-609 and isoform-specific siRNAs show that CaMKKbeta is required for this effect |
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33. |
AMPK has a central role in stimulus-response coupling by hypoxia |
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34. |
AMPK is a major regulator of skeletal muscle HSL activity that can override beta-adrenergic stimulation |
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35. |
Role of AMPK in tolerance to glucose starvation in cell lines |
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36. |
Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells. |
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37. |
Oral glucose ingestion attenuates the exercise-induced activation of alpha2-AMPK, bringing further support for a fuel-sensing role of AMPK in skeletal muscle. |
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38. |
PRKAA2 gene influences insulin resistance and susceptibility to type 2 diabetes in the Japanese population. |
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39. |
Hepatic amino acid-dependent signaling is under the control of AMP-dependent protein kinase. |
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40. |
Overexpression of mutant AMPK-alpha1 enhanced forskolin-stimulated I short-circuit currents, consistent with dominant-negative reduction in inhibition of CFTR by endogenous AMPK. |
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41. |
endothelial AMPK signaling may be a critical determinant of blood vessel recruitment to tissues that are subjected to ischemic stress. |