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the active form of the alpha-catalytic AMPK subunit (P-AMPKalphaThr172)transiently associates with several mitotic structures including centrosomes, spindle poles, the central spindle midzone and the midbody throughout all of the mitotic stages and cyt... |
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Data show that kidney bean husk extract exhibited antitumor effects accompanied by the increase in p-AMPK and p-Acc as well as antitumor proteins p53 and p21. |
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Findings suggest that both COX-2 stimulators (TPA and H(2)O(2)) might have differential effects on COX-2 and AMPK regulation and further apoptotic regulation. |
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Results indicate that the liberation of excessive ROS might be the upstream signal of the AMPK-COX-2 signaling pathway |
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Results indicate that AMPK is crucial in apoptosis induced by curcumin and further that the pAkt-AMPK-COX-2 cascade or AMPK-pAkt-COX-2 pathway is important in cell proliferation and apoptosis in colon cancer cells. |
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AMPK inhibits myoblast differentiation through a PGC-1alpha-dependent mechanism. |
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AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells. |
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TRAIL-induced AMPK activation depends on transforming growth factor-beta-activating kinase 1 (TAK1) and TAK1-binding subunit 2. |
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Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
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Adiponectin-induced growth inhibition is significantly attenuated when AMPK level is reduced using small interfering RNA, indicating that AMPK is involved in mediating the antiproliferative action of this adipokine. |
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although the molecular mechanism underlying AMPK activation via the forskolin stimulation is unclear, the tight junction formation induced by forskolin is likely to be mediated by the AMPK pathway in trophoblasts |
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AMPK activation partially contributes to the cytotoxic effect of curcumin in ovarian cancer cells |
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AMP-activated protein kinase alpha-1 subunit is a potent counterregulator of inflammatory signaling pathways in macrophages. |
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D-xylose derivatives stimulate muscle glucose uptake by activating AMP-activated protein kinase alpha |
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AMPK alpha2 activity, AMPK alpha2 Thr172 phosphorylation, and ACC-beta Ser222 phosphorylation were increased immediately after exercise. These increases had all returned to basal levels at 3 and 24 h after exercise. |
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Results demonstrate that AMPK-alpha1 and AMPK-alpha2 activity and fuel selection in skeletal muscle in response to exercise can be manipulated by diet and/or the interactive effects of diet and exercise training. |
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rosiglitazone is able to acutely stimulate NO synthesis in cultured endothelial cells by an AMP-activated protein kinase-dependent mechanism, likely to be mediated by LKB1 |
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alpha2 But not alpha1 AMP-activated protein kinase mediates oxidative stress-induced inhibition of retinal pigment epithelium cell phagocytosis of photoreceptor outer segments |
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Ultrasound increased COX-2 expression in osteoblasts via the LKB1/AMPKalpha1/p38/IKKalphabeta and NF-kappaB signaling pathway. |
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The dynamic of AMPK activity was consistent with a prosurvival role during chronic hypoxia. |
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repeated, high-intensity exercise that leads to clinically relevant immunosuppression may do so via AMPK inactivation within immune cells |
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Trained human skeletal muscle has increased alpha(1)-AMPK protein levels and blunted AMPK activation during exercise. |
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IGF-1 induces AMPK-alpha subunit phosphorylation via an ATM-dependent and LKB1-independent pathway |
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interaction between Leu-328 and Val-298 plays an important role in AMPK alpha autoinhibitory function |
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AMPK activation is linked with reductions in cAMP-mediated epithelial chloride flux and may be a contributing factor to the hyporesponsiveness seen under conditions of chronic inflammation. |
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These are the first data to show an effect of AMPK on cell movement, and suggest a fundamental role for energy deficiency in regulating cellular behaviour. |
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The data provide novel insight into the subunit composition of the epithelial CFTR/AMPK/NDPK complex, such that: CFTR interacts specifically with AMPK alpha1, gamma2 and NDPK-A and not NDPK-B or AMPK gamma1. |
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Role of AMPK in tolerance to glucose starvation in cell lines |