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1: ACLY ATP citrate lyase [ Homo sapiens ]

GeneID: 47 updated 21-Nov-2009

[Top][Help]Summary

Official Symbol
ACLYprovided by HGNC
Official Full Name
ATP citrate lyaseprovided by HGNC
Primary Source
HGNC:115
See related
Ensembl:ENSG00000131473; HPRD:00155; MIM:108728
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACL; ATPCL; CLATP; ACLY
Summary
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]

[Top][Help]Genomic regions, transcripts, and products

(minus strand) Go to reference sequence detailsTry our new Sequence Viewer


[Top][Help]Genomic context

chromosome: 17; Location: 17q12-q21See ACLY in MapViewer

[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into Function What's a GeneRIF?

PubMed 1. The activities of ATP citrate lyase were decreased by 57% in pancreatic islets of patients with type 2 diabetes.
PubMed 2. findings suggest that ATP-citrate lyase activity is required to link growth factor-induced increases in nutrient metabolism to the regulation of histone acetylation and gene expression
PubMed 3. Atp citrate lyase is involved in lung cancer pathogenesis associated with metabolic abnormality and might offer a novel therapeutic target.
PubMed 4. Observational study of gene-disease association. (HuGE Navigator)
PubMed 5. Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
PubMed 6. data presented indicate that the ATP citrate lyase pathway is operative in human platelets and may be responsible for increased acetyl-CoA in diabetic platelets which may be the cause of their excessive activity in the course of the disease
Submit: New GeneRIF Correction

[Top][Help]Interactions

Description ..........
  Product Interactant Other Gene Complex Source Pubs          
Affinity Capture-MS
  BioGRID:106563   BioGRID:109187   GSK3B      BioGRID    PubMed
Reconstituted Complex
  BioGRID:106563   BioGRID:114593   HGS      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:106563   BioGRID:115000   IKBKE      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:106563   BioGRID:110895   NME2      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:106563   BioGRID:111551   PRKAB1      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:106563   BioGRID:112888   TFE3      BioGRID    PubMed

[Top][Help]General gene information

Markers

GDB:392280(e-PCR)
Links: UniSTS:157185
D17S1205(e-PCR)
Links: UniSTS:69157
D17S2155(e-PCR)
Links: UniSTS:5950
WI-20027(e-PCR)
Links: UniSTS:69195
SHGC-132072(e-PCR)
Links: UniSTS:170629
D17S1209(e-PCR)
Links: UniSTS:52644
WI-19716(e-PCR)
Links: UniSTS:30916
SHGC-11986(e-PCR)
Links: UniSTS:3576

Homology

Homologs of the ACLY gene The ACLY gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, M.grisea, N.crassa, A.thaliana, and rice.


Map Viewer (Mouse, Rat)

Pathways

KEGG pathway: Citrate cycle (TCA cycle)
00020
KEGG pathway: Metabolic pathways
01100
Reactome Event:Integration of energy metabolism
REACT_1505
Reactome Event:Metabolism of lipids and lipoproteins
REACT_602

[Top][Help]General protein information

Preferred Names
ATP citrate lyase
Names
ATP citrate lyase
OTTHUMP00000164773
NP_001087.2
EC 2.3.3.8
NP_942127.1
EC 2.3.3.8

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

  1. NM_001096.2 → NP_001087.2  ATP citrate lyase isoform 1

    Description
    Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (1).
    Source sequence(s)
    BC006195,BG037168
    Consensus CDS
    CCDS11412.1
    UniProtKB/Swiss-Prot
    P53396
    Conserved Domains (5) summary
    COG0045
    Location:6 – 415
    Blast Score: 464
    SucC; Succinyl-CoA synthetase, beta subunit [Energy production and conversion]
    cd06100
    Location:856 – 1093
    Blast Score: 745
    CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA)...
    pfam00549
    Location:642 – 787
    Blast Score: 308
    Ligase_CoA; CoA-ligase
    cl03087
    Location:55 – 207
    Blast Score: 92
    Dala_Dala_lig_C; D-ala D-ala ligase C-terminus
    cl09931
    Location:492 – 601
    Blast Score: 144
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_198830.1 → NP_942127.1  ATP citrate lyase isoform 2

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    BC006195,BG037168
    Consensus CDS
    CCDS11413.1
    UniProtKB/Swiss-Prot
    P53396
    Conserved Domains (5) summary
    COG0045
    Location:6 – 415
    Blast Score: 463
    SucC; Succinyl-CoA synthetase, beta subunit [Energy production and conversion]
    cd06100
    Location:846 – 1083
    Blast Score: 744
    CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA)...
    pfam00549
    Location:632 – 777
    Blast Score: 307
    Ligase_CoA; CoA-ligase
    cl03087
    Location:55 – 207
    Blast Score: 92
    Dala_Dala_lig_C; D-ala D-ala ligase C-terminus
    cl09931
    Location:482 – 591
    Blast Score: 144
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000017.10

    Range
    40023178..40075271, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NT_010783.15 

    Range
    5297330..5349423, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

  1. AC_000060.1

    Range
    36674339..36725808, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_926828.1 

    Range
    3545530..3596999, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

  1. AC_000149.1

    Range
    35785141..35836956
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_001838436.2 

    Range
    1326768..1378583
    Download
    GenBank FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

  Nucleotide   Protein
  genomic   AC091172.11  (84159..136252)   None
  genomic   CH471152.1   EAW60777.1
       EAW60778.1
       EAW60779.1
       EAW60780.1
       EAW60781.1
  mRNA   AB210035.1   BAE06117.1
  mRNA   AK095084.1   BAC04484.1
  mRNA   AK295675.1   BAG58532.1
  mRNA   AK304802.1   BAG65552.1
  mRNA   AK312315.1   None
  mRNA   BC006195.2   AAH06195.1
  mRNA   BG037168.1   None
  mRNA   U18197.1   AAB60340.1
  mRNA   X64330.1   CAA45614.1
Protein Accession   Links
P53396.3   GenPept   UniProtKB/Swiss-Prot:P53396
Q4LE36   GenPept   UniProtKB/TrEMBL:Q4LE36
Q8N9C4   GenPept   UniProtKB/TrEMBL:Q8N9C4

[Top][Help]Additional Links