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1. |
FoxO4 is down-regulated in patients with inflammatory bowel disease. |
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2. |
The model of the complex suggests that the forkhead domain of FOXO4 is docked within the central channel of the 14-3-3 protein dimer, consistent with the hypothesis that 14-3-3 masks the DNA binding interface of FOXO4. |
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3. |
Results suggest that the expression of FOXO1 and FOXO4 genes is stimulated by FOXO3 and possibly by other FOXO factors in a positive feedback loop, which is disrupted by growth factors. |
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4. |
FOXO1, FOXO3, and FOXO4 are expressed in human luteinized mural granulosa cells, which may suggest that these transcription factors are also involved in human folliculogenesis and luteinization. |
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5. |
The patients with immunophenotype of Pre-B-acute lymphoblastic leukemia were found to carry: MLL/AFX. |
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6. |
Pin1 is identified as a novel negative FOXO regulator, interconnecting FOXO phosphorylation and monoubiquitination in response to cellular stress to regulate p27(kip1). |
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7. |
AFX splice variants exhibit dominant negative activity and inhibit AFXalpha-mediated tumor cell apoptosis |
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8. |
Mdm2 induces mono-ubiquitination of FOXO4 |
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9. |
Observational study of gene-disease association. (HuGE Navigator) |
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10. |
CBP-induced acetylation of AFX is a novel modification mechanism by which AFX keeps the transcriptional activity mitigating in the nucleus |
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11. |
FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism |
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12. |
FOXO4 gene as a novel anticancer agent for HER2-overexpressing cells. |
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13. |
Data show that low levels of oxidative stress generated by treatment with hydrogen peroxide induce the activation of FOXO4. |
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14. |
Introduction of dominant-negative FoxO into mousse cells partially rescues cAMP-induced inhibition of proliferation. |
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15. |
AFX zeta is a downstream target of both the phosphatidylinositol 3-kinase/PKB insulin signaling pathway and an AMP-activated protein kinase-dependent pathway. |
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16. |
results demonstrate a role for beta-catenin in regulating FOXO function that is particularly important under conditions of oxidative stress |
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17. |
DNA-binding domain of FoxO4 remains relatively mobile while bound to the 14-3-3 protein. |
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18. |
the MLL-AFX fusion protein requires the transcriptional effector domains of AFX to transform myeloid progenitors and interfere with forkhead protein function |
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19. |
Phosphorylation of FOXO4 by protein kinase B on threonine-28 and serine-193 leads to a tight association of FOXO4 with 14-3-3 zeta, causing complete inhibition of DNA binding, most likely by masking of the DNA binding surface of Forkhead domain by 14-3-3. |
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20. |
Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors |
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21. |
Data demonstrate that acetylation functions in a second pathway of negative control for FOXO factors and provides a novel mechanism whereby hSir2(SIRT1) can promote cellular survival and increase lifespan. |
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22. |
fMLP-stimulated neutrophils coordinate the regulation of FOXO transcription factors and the survival factor Mcl-1, a mechanism that may allow neutrophils to alter their survival. |
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23. |
The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor. |
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24. |
results show that Forkhead transcription factor 4-dependent expression of Bim protein plays a pivotal role for endothelial progenitor cell apoptosis |
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25. |
both N- and C-terminal regions of forkhead domain are important for stability of the FoxO4-DBD.DNA complex |