|
1. |
beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent signalling |
|
|
2. |
Beta-arrestin is required for the maintenance of a beta1-Adrenergic receptor -epidermal growth factor receptor interaction that can direct cytosolic targeting of extracellular regulated kinase in response to catecholamine stimulation. |
|
|
3. |
beta-arrestin |
|
|
4. |
Examined interactions between phosphodiesterase 4D5 (PDE4D5) and beta-arrestin and RACK1. |
|
|
5. |
Neither RXFP1 nor RXFP2 activation results in recruitment of beta-arrestins to the cell surface, whereas AT(1)R rapidly recruits both beta-arrestins-1 and -2 |
|
|
6. |
beta-arrestins and c-Src are implicated in the activation of Akt in response to ghrelin through the GHS-R1a |
|
|
7. |
MEK1 binds directly to betaarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization |
|
|
8. |
beta-Arrestins play a negative regulatory role in hydroegn peroxide-induced apoptosis signaling through associating with ASK1 and CHIP and facilitating ASK1 degradation. |
|
|
9. |
Results identify novel functions of beta-arrestin1 in binding to the beta1gamma2 subunits of heterotrimeric G-proteins and promoting G(betagamma)-mediated Akt signalling for NF-kappaB activation. |
|
|
10. |
These findings demonstrate that physical interaction of CaM with recombinant and native 5-HT(2C) receptors is critical for G protein-independent, arrestin-dependent receptor signaling. |
|
|
11. |
Agonist-selective, receptor-specific interaction of human P2Y receptors with beta-arrestin-1 and -2. |
|
|
12. |
analysis of the protein kinase A-independent, beta-arrestin-1-dependent signaling pathway for p38 mitogen-activated protein kinase activation by beta2-adrenergic receptors |
|
|
13. |
These results show that G(i2) protein is involved in D(2)R-mediated ERK activation but beta-arrestins 1 and 2 are either not involved or play minor role. |
|
|
14. |
Results reveal that nuclear beta-arrestin1, acting as a scaffold for the dephosphorylation of STAT1, is an essential negative regulator of IFN-gamma signaling and participates in the IFN-gamma-induced cellular antiviral response. |
|
|
15. |
beta-arrestins direct the localization of PIP5K Ialpha and PIP(2) production to agonist-activated 7TMRs, thereby regulating receptor internalization |
|
|
16. |
beta-arrestins regulate protein synthesis |
|
|
17. |
ARRB1 and ARRB2 play an important role in biological processes involved in the regulation of smoking urgency (that is time to smoke first cigarette). |
|
|
18. |
Observational study of gene-disease association. (HuGE Navigator) |
|
|
19. |
overexpression of beta-Arr1 promotes matrix metalloproteinase 9 activity and tumor angiogenesis by providing a suitable microenvironment for tumor progression |
|
|
20. |
the AIP4.arrestin-2 complex functions on endosomes to regulate sorting of CXCR4 into the degradative pathway |
|
|
21. |
MS patients had a greater prevalence of positive T-cell proliferative responses to neuron-specific enolase [NSE], retinal arrestin, and beta-arrestin than healthy controls (p<0.0001). |
|
|
22. |
data suggest cells ruffle upon CaSR (calcium sensing receptor)stimulation via a mechanism that involves translocation of beta-arrestin 1 pre-assembled with the CaSR or ARNO (Arf nucleotide binding site opener) |
|
|
23. |
Data show that 5-HT(4) receptor stimulation in primary neurons produced a potent but transient activation of the ERK pathway that is dependent on Src tyrosine kinase but totally independent of beta-arrestin. |
|
|
24. |
c-Src has a role in regulating the dissociation of AP-2 from agonist-occupied AT1R and beta-arrestin during the clathrin-mediated internalization of receptors |
|
|
25. |
Our results show that PAR1-mediated activation of Src and ERK1/2 in HEK 293 cells was increased with overexpression of beta-arrestin1 or depletion of beta-arrestin2. |
|
|
26. |
beta-arrestin 1 is a mediator of cellular migration and metastasis |
|
|
27. |
D6 is constitutively internalized via a ligand-independent, phosphorylation-independent association with beta-arrestin. |
|
|
28. |
Mononuclear leukocytes of patients with depression showed significantly reduced immunoreactive quantities of beta-arrestin-1 |
|
|
29. |
the beta2 adrenergic receptor has a role in beta-arrestin-dependent, G protein-independent ERK1/2 activation |
|
|
30. |
beta-arrestin and G proteins activate parathyroid hormone receptor-stimulated ERK1/2 pathways |
|
|
31. |
both beta-arrestin1 recruitment and the presence of Ser/Thr residues in the distal half of the C-terminal domain were necessary for maximal agonist-induced internalization |
|
|
32. |
protease-activated receptor-2-mediated migration of tumor cells requires both beta-arrestin-1 and -2 |
|
|
33. |
examination of desensitization, internalization, and signaling functions demonstrated by RNA interference |
|
|
34. |
Determinants in the receptor's core (Asn-289 and Lys-382) appear to regulate internalization of the receptor/beta-arrestin complex toward early endocytic endosomes during the initial step of endocytosis. |
|
|
35. |
results suggest that physiological levels of beta-arrestin1 may act as "dominant-negative" inhibitors of beta-arrestin2-mediated extracellular signal-regulated kinases 1 and 2 activation |
|
|
36. |
findings suggest that beta-arrestin 1 acts as an effector for a novel function of PTHrP in cytoplasm |
|
|
37. |
beta-Arrestin 1 and Galphaq/11 have roles in activating RhoA and stress fiber formation following receptor stimulation |
|
|
38. |
results demonstrate the ability of beta-arrestins to recruit diacylglycerol kinases to ligand-activated M1 muscarinic receptors |
|
|
39. |
role of beta-arrestin, dynamin, and clathrin-dependent pathway in internalization of the complement 5a anaphylatoxin receptor |
|
|
40. |
Endogenous beta-arrestin1 functions exclusively in the phosphorylation-dependent receptor internalization, whereas endogenous beta-arrestin2, but not beta-arrestin1, is required for the phosphorylation-independent receptor internalization. |
|
|
41. |
ERK1/2 is activated by a chimeric neurokinin 1 receptor-beta-arrestin1 fusion protein |
|
|
42. |
beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform. |
|
|
43. |
beta-arrestin has a role in ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase |
|
|
44. |
results suggest that a GPCR conformation directed by the second intracellular loop, likely using the loop itself as a binding patch, may function as a switch for transitioning beta-arrestin from its inactive form to its active receptor-binding state. |
|
|
45. |
analysis of the G protein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor |
|
|
46. |
subcellular localization is determined by their intact N domain and the nuclear export signal at the C terminus |
|
|
47. |
Platelet-activating factor signaling requires beta-arrestin-1 recruitment of a p38 MAP kinase signalosome for transduction before neutrophil endosomal scission. |