Official Symbol

ARAFprovided by HGNC

Official Full Name

v-raf murine sarcoma 3611 viral oncogene homologprovided by HGNC

Primary Source

HGNC:646

Locus Tag

RP1-230G1.1

See related

Ensembl:ENSG00000078061; HPRD:02405; MIM:311010

Gene type

protein coding

RefSeq status

VALIDATED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Also known as

PKS2; A-RAF; ARAF1; RAFA1; ARAF

(plus) Go to reference sequence detailsTry our new Sequence Viewer

chromosome: X; Location: Xp11.4-p11.2See ARAF in MapViewer

Preferred Names

v-raf murine sarcoma 3611 viral oncogene homolog

Names

v-raf murine sarcoma 3611 viral oncogene homolog

Oncogene ARAF1

Ras-binding protein DA-Raf

v-raf murine sarcoma 3611 viral oncogene homolog 1

NP_001645.1

EC 2.7.11.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_001654.2 → NP_001645.1  v-raf murine sarcoma 3611 viral oncogene homolog

   Source sequence(s)

   BC002466,DA264472

   Consensus CDS

   CCDS35232.1

   UniProtKB/Swiss-Prot

   P10398

   Conserved Domains (4) summary

   cd00029
   Location:99 – 144
   Blast Score: 147

   C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second...

   cd00180
   Location:311 – 565
   Blast Score: 528

   S_TKc; Serine/Threonine protein kinases, catalytic domain. Phosphotransferases of the serine or threonine-specific kinase subfamily. The enzymatic activity of these protein kinases is controlled by phosphorylation of specific residues in the activation...

   cd01816
   Location:20 – 91
   Blast Score: 277

   Raf_RBD; CR2 and CR3. CR1 has two Ras binding domains (RBD and CRD), CR2 is a serine/threonine rich domain and CR3 is the catalytic kinase domain. The RBD of Raf is structurally similar to ubiquitin with little of no sequence similarity.The Raf signalling...

   pfam00069
   Location:311 – 564
   Blast Score: 612

   Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

1. NC_000023.10

   Range

   47420577..47431319

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NT_079573.4 

   Range

   10272321..10283063

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

1. AC_000066.1

   Range

   51615835..51626576

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_927702.1 

   Range

   2427176..2437917

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

1. AC_000155.1

   Range

   45132809..45143539

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_001842362.1 

   Range

   2418806..2429536

   Download

   GenBank FASTA Sequence Viewer (Graphics)