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1. |
Acute, incremental, fatiguing, submaximal exercise stress in sedentary middle-aged men results in an increase in sgp130. |
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2. |
These results indicate that humanin protects neurons by binding to a complex or complexes involving CNTFR/WSX-1/gp130. |
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3. |
Patients at risk of acute tubular necrosis after kidney transplanation display low levels of soluble glycoprotein 130. |
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4. |
GP130 serum concentrations correlated with blood pressure in stroke patients and elderly and young controls and with the intima-media thickness of the common artery in stroke patients. |
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5. |
The expression of gp130 is down-regulated in patients with NPC. |
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6. |
Results suggest that disease activity as well as immunotherapy seems to influence the pattern of expression of gp130 on B-cell subsets in patients with systemic lupus erythematosus. |
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7. |
increased ratio of sgp130/sIL-6R production and/or reduced sIL-6R production combined with down-regulation of IL-6R and SOCS-3 expression in trophoblasts may lead to less cytokine inhibitory activity in preeclampsia placentas |
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8. |
recurrent gain-of-function gp130 mutations in these human hepatocellular adenomas fully explains activation of the acute inflammatory phase observed in tumourous hepatocytes |
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9. |
IL-6 treatment induced MUC4 expression through the gp130/STAT3 pathway, indicating the direct role of IL-6 on the activation of the intestinal mucin gene MUC4 in gastric cancer cells |
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10. |
Increasing the level of G{130 may assist in reducing the inflammatory changes induced by IL-6 transsignaling in uveitis aqueous humor. |
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11. |
Astrocytic gp130 expression is crucial for survival of transgenic glial fibrillary acid protein (GFAP)-positive astrocytes in murine Toxoplasma encephalitis (TE). Astrocyte loss results in a lethal course of TE. |
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12. |
Results present the biophysical and structural characterization of the full-length, transmembrane form of a quaternary cytokine receptor complex consisting of gp130, LIF-R, Ciliary Neurotrophic Factor (CNTF), and its alpha receptor (CNTF-Ralpha). |
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13. |
Active expression of transgenic Stat6 in IL-4-deficient mouse lymphocytes alters lymphocyte homeostasis and promotes T helper (Th) type 2 cell differentiation in vitro. |
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14. |
The lysosomal degradation of gp130 is critical for cessation of IL-6-mediated signaling. |
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15. |
Knockdown of IL6ST (lentiviral infection with shRNA)in HEK293 cells expressing AblPP constitutively is associated with enhanced cell attachment. |
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16. |
we highlight the key role of the gp130 receptor and its major downstream effectors in the heart in terms of development and regeneration--REVIEW |
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17. |
IL6ST variants are possible determinants of impaired glucose metabolism and other abnormalities of metabolic syndrome. |
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18. |
The expression of IL-6 and IL-6R (gp80, gp130) was studied by confocal immunofluorescence, rtPCR and Western blotting. Lipopolysaccharide (LPS) stimulation experiments were conducted in smooth muscle cell cultures of bladder biopsies of tumor patients. |
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19. |
administration of IL-6 could activate receptor gp80/gp130 signaling pathways including downstream extracellular signal-regulated kinase 1/2 and STAT3 phosphorylation in EPCs. |
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20. |
Observational study of gene-disease association. (HuGE Navigator) |
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21. |
Increased expression of some IL-6 cytokine family members (oncostatin M, gp130, CT-1, LIF) in cutaneous inflammation might contribute to the promotion of hair loss. |
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22. |
EGFR could activate the gp130/JAK/STAT3 pathway by means of IL-6 upregulation in primary human lung adenocarcinomas, making this pathway a potential target for cancer treatment. |
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23. |
SHP2-mediated signaling cascade is essential for the LIF and IL-6+sIL-6r-dependent increase in I(CaL), [Ca(2+)](i) transient and action potential duration. |
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24. |
gp130 protein expression (P < 0.05) and p42/44 MAPK and PI3K/Akt activation (P < 0.01) were decreased in heart-failure hypertensive patients compared with nonheart-failure hypertensive individuals. |
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25. |
IL-6/sIL-6R complex trans-signaling via gp130 is an exacerbating factor of ACD, and that the concentration of sIL-6R in tears is a useful clinical biomarker in patients with ACD. |
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26. |
A higher gene expression of CRP, IL-6, and both IL-6 membrane receptors in subcutaneous samples of inflamed patients than in healthy controls. |
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27. |
gp130 modulates atherosclerosis in mice and human |
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28. |
detection in pericardial fluid in coronary pathologies |
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29. |
Results suggest that the balance between soluble and membrane-bound gp130 may play an important role in regulating cytokine action necessary for blastocyst implantation and for further interaction between the decidualized endometrium and the trophoblast. |
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30. |
a structural model, derived from 3.65 A resolution crystallographic data of the complex between IL-6, the extracellular binding domains of IL-6R, and the extracellular activation and binding domains of gp130 is presented |
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31. |
There is no significant effect of IL-18 on the release of both soluble receptors of IL-6. |
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32. |
Two distinct Stat3 signaling pathways emanating from gp130 are utilized in mammary tissue. |
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33. |
Gp130 activation by soluble IL-6 receptors and IL-6 enhances osteoblastic differfentiation of human bone marrow-derived mesenchymal cells. |
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34. |
urokinase-type plasminogen activator induces upregulated expression of the complement anaphylatoxin C5a receptor; this effect is mediated via the interaction of the uPA-specific receptor and gp130 |
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35. |
potential role of gp130 receptor ligands as part of a therapeutic strategy to treat obesity. |
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36. |
interaction with cyclin-dependent kinase 9 |
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37. |
Simultaneous action of two IL-6 binding domains on two gp130 molecules is required to efficiently recruit a fluorescent IL-6 (yellow fluorescent protein-IL-6) to the plasma membrane. |
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38. |
Data suggest that interleukin-6 activation of gp130 promoted cell division in fibroblasts from patients with idiopathic pulmonary fibrosis (IPF), while IL-11 was mitogenic in both normal and IPF cells. |
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39. |
Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. |
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40. |
Gp130 and ras mediated signaling in human plasma cell line INA-6: a cytokine-regulated tumor model for plasmacytoma. |
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41. |
Diminished GP130 Abundance in congestive heart failure |
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42. |
GP130 together with the cytokine receptor WSX-1 constitutes a functional signal-transducing receptor for IL-27. |
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43. |
CD30 can modify eosinophil survival by causing an extremely rapid and intense induction of apoptosis through a tightly regulated intracellular signaling pathway. |
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44. |
interactions of CNTFR with LIFR and gp130 in vitro |
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45. |
These findings indicate that the di-leucine motif which directs the internalization of the IL-6 receptor complex also mediates the basolateral sorting of the signal transducer gp130. |
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46. |
there are tissue-specific differences in IL-6-receptor-gp130-coupled signaling which limit the extent of Stat3 activation and gammaFBG expression during lung inflammation |
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47. |
decreased expression of GP130 in ejaculated spermatozoa could be associated with low sperm motility in asthenozoospermic men. |
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48. |
gp130 has a role in glucose-enhanced interleukin-6-induced VEGF165 expression |
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49. |
The function of IL-6R in the luminal and glandular epithelium might be different from that in the stroma during the implantation period. |
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50. |
A crystal structure of the ligand-binding domains of gp130 in complex with human interleukin-6 (IL-6) and its a-receptor (IL-6Ralpha). |
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51. |
PKC delta associates with IL6ST via Stat3 and enhances Stat3-gp130 interaction |
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52. |
There is no evidence that mutations in exon 17 of the gp130 gene are involved in the pathogenesis of human inflammatory bowel disease |
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53. |
physical evidence of the stabilization of vIL-6-induced gp130 signaling complexes by gp80 |
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54. |
RT-PCR analysis showed that glioma tumor cells express oncostatin M receptors. |
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55. |
sOSMR is able to bind OSM and interleukin-31 when associated to soluble gp130 or soluble interleukin-31R, respectively, and to neutralize both cytokine properties |
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56. |
Soluble gp130 is up-regulated in the implantation window and shows altered secretion in patients with primary unexplained infertility. |
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57. |
Shedding of the interleukin-6 (IL-6) receptor (gp80) determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts |
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58. |
involvement of IL-6 in the pathogenesis of liver diseases and suggest a protective role of IL-6/gp130-dependent pathways in nonparenchymal liver cells during fibrosis progression in chronic liver diseases. |
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59. |
Endotoxemia up-regulates gp130 expression in vivo and in vitro. |
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60. |
demonstrates the existence of preformed but inactive gp130/leukemia inhibitory factor receptor hetero- and gp130/gp130 homo-dimers |
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61. |
metastatic melanoma cells could escape this growth control by the epigenetic silencing of oncostatin M receptor beta |
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62. |
activation of RankL gene expression by PKA- and gp130-inducers is mediated via common regulatory domains that also served to facilitate the activity of 1,25-(OH)2D3 |
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63. |
The transcription co-repressor TLE1 interacted with the intracellular region of gpl30 through its Q domain |
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64. |
gp130 signal transduction is important for the differentiation and maturation of dendritic cells |
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65. |
regulation of surface expression by janus kinase 1 |
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66. |
LMO4 interaction modulates the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling |
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67. |
Vav interacts with gp130. |