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1. |
5-LO was the enzyme responsible for the generation of the HepsilondGuo DNA-adduct in CESS cells. |
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2. |
one in the promoter and one spanning six SNPs from rs3740107G>A in intron 6 to rs2229136A>G in exon 13.five-repeat genotype was the most frequent Sp1/Egr1 promoter tandem repeat variant |
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3. |
Genotyping the GGGCGG tandem repeat promoter polymorphism in ALOX5 by pyrosequencing assay is reported. |
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4. |
Nine SNPs distributed across eight genetic regions (ALOX5, IRAK3, ITGB2, NCF2, NFKB1, SELP, SOD1, and STAT1) were associated with risk of glioma with P value of <0.01. |
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5. |
Observational study of genetic testing. (HuGE Navigator) |
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6. |
Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
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7. |
Grape seed and red wine polyphenol extracts inhibit this enzyme in seveal tumor cell lines. |
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8. |
LTC(4)S interacts in vitro with both FLAP and 5-LO and that these interactions involve distinct parts of LTC(4)S. |
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9. |
The development of methodology for clinical measurement of ALOX5 intermediates from peripheral blood mononuclear cells is reported. |
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10. |
Results suggest that the formation of miRNAs may be regulated by 5LO in leukocytes and cancer cells expressing this lipoxygenase. |
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11. |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
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12. |
a role of the 5-LO pathway in B cells before the cells finally differentiate to plasma cells |
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13. |
nuclear import, which is regulated by phosphorylation on Ser-523, to determine the subcellular distribution of 5-LO, which in turn regulates leukotriene biosynthesis. |
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14. |
identify multiprotein complexes for leukotriene synthesis on the outer and inner nuclear membranes of mast cells and neutrophils, centered on the 5-Lipoxygenase-Activating Protein and 5-Lipoxygenase |
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15. |
microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase can be inhibited by pirinixic acid derivatives |
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16. |
The pro-inflammatory alleles of COX-2 and 5-LO were overrepresented in MI and under-represented in centenarians whereas age-related controls displayed intermediate values |
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17. |
No significant effect of ALOX5 genotype on breast cnacer risk. |
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18. |
5-lipoxygenase is upregulated in the Alzheimer's disease hippocampus. |
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19. |
5-LOX is overexpressed in adenomatous polyps and cancer. |
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20. |
data do not provide consistent evidence of association between genomic variation in ALOX5 and clinical variability in aBMD in healthy |
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21. |
variant 5-lipoxygenase promoter genotypes do not have a major role in myocardial infarction |
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22. |
Report the long-term effect of Helicobacter pylori eradication on COX-1/2, 5-LOX and leukotriene receptors in patients with a risk gastritis phenotype--a link to gastric carcinogenesis. |
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23. |
There is a relationship between 5-LO expression and the neoangiogenesis process as reflected by intratumoral microvessel density in human sporadic colorectal adenocarcinomas. |
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24. |
The 3 and 4 variants lead to higher 5-LO expression and provide additional evidence that these alleles are associated with greater risks of atherosclerosis and MI in the context of a high-AA diet. |
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25. |
Role of ALOX5 in pancreatic function in human islets is assessed through short interfering RNA (siRNA) knockdown experiments. |
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26. |
Describe an ex vivo human whole blood assay to evaluate the efficacy and selectivity of 5-LOX inhibitors. |
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27. |
Results describe the cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) selectivity of COX inhibitors. |
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28. |
Tertiary-butanolcauses moderate suppression of 5-LO and hardly inhibits 5-LO translocation in polymorphonuclear leukocytes. |
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29. |
5-LOX was expressed in 6% of ovarian neoplasms. |
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30. |
findings do not support a link between common allelic variation in or near ALOX5 or ALOX5AP and the risk of coronary artery disease |
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31. |
The observation of an association of ALOX5 variants with susceptibility to tuberculosis contributes evidence of the importance of 5-LO products to the regulation of immune responses to M. tuberculosis. |
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32. |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
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33. |
Observational study of gene-gene interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
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34. |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
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35. |
Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
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36. |
Observational study of gene-disease association. (HuGE Navigator) |
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37. |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
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38. |
Uncategorized study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
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39. |
These results suggest that E254K in the 5-LO might be associated with bronchial asthma. |
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40. |
CMV infection induces 5-lipoxygenase expression and leukotriene B4 production in vascular smooth muscle cells |
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41. |
Suppression of 5-lipoxygenase gene is involved in triptolide-induced apoptosis in pancreatic tumor cell lines. |
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42. |
These results suggest that overexpression of 5-LO and LTB(4) in atherosclerotic plaques possibly promote MMP-induced plaque rupture in diabetes. |
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43. |
TsA increases 5-LO promoter activity by the enhanced recruitment of Sp1 and Sp3 to the 5-LO promoter |
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44. |
ANXA7 and p53 can distinctly regulate LOX transcription that is potentially relevant to the arachidonic acid -mediated cell growth control in tumor suppression. |
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45. |
involved in tumor progression of several cell types and may also participate in lymphomagenesis, especially Epstein Barr virus-mediated. |
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46. |
Multiple ALOX5 single nucleotide polymorphisms (SNPs) independently predict severe carotid artery disease. |
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47. |
promotion of phosphorylation at Ser-271 by MAPK-activated protein kinase 2 and arachidonic acid |
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48. |
5-lipoxygenase can be activated by calcium and low levels of hydroperoxides |
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49. |
Coactosin-like protein (CLP) up-regulates Ca(2+)-induced 5-lipoxygenase (5LO) activity, and increases the amount of Leukotriene A(4) formed by 5LO. |
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50. |
marked expression of 5-LOX in human pancreatic cancer tissues |
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51. |
a critical regulatory role of arachidonate reacylation that limits leukotriene biosynthesis in concert with 5-lipoxygenase and cytosolic phospholipase A(2)alpha activation |
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52. |
mizolastine down-regulated 5-LOX mRNA expression and inhibited 5-LOX translocation from nucleus to cytoplasm in fibroblasts |
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53. |
Sequence analysis and deletion studies indicate the existence of up to four Smad binding elements and at least one TGFbeta responsive element far downstream of the transcriptional start site of the 5-lipoxygenase gene. |
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54. |
analysis of vitamin D receptor (VDR) binding to putative vitamin D response elements within the 5-LO promoter and analysis its function |
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55. |
increased expressions of 5-LOX and 12-LOX were detected in testicular cancer tissues |
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56. |
Up-regulation of 5-Lipoxygenase is associated with prostate cancer |
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57. |
The expression of 5-LO is elevated in symptomatic compared with asymptomatic plaques and is associated with acute ischemic syndromes |
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58. |
The binding between human 5-lipoxygenase with its inhibitors can be investigated by SPR technology and molecular docking simulation. |
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59. |
examines the binding of calcium to this enzyme (REVIEW) |
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60. |
Data show that inhibition of arachidonate 5-lipoxygenase induces rapid activation of c-Jun N-terminal kinase (JNK) in human prostate cancer cells which is prevented by the 5-lipoxygenase metabolite, 5(S)-HETE. |
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61. |
Data show that 5-lipoxygenase activity increases during senescence-like growth arrest via a p53/p21-dependent pathway in both human and mouse embryo fibroblasts. |
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62. |
In the absence of Ca2+ (chelated using EDTA), OAG strongly and concentration-dependently stimulated 5-LO enzyme from polymorphonuclear leukocytes |
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63. |
results demonstrating mechanisms for activation of 5-LO differ considerably between cell types |
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64. |
Mutagenesis of 5LO C-terminal mutants showed that hidrogen bonds are required for a stabilizing C-terminal loop. |
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65. |
Theoretical model of the tertiary structure of the 5-lipoxygenase catalytic domain, using the resolved structure of rabbit 15-lipoxygenase as a template. |
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66. |
Arachidonic acid regulates the translocation of 5-LO in human neutophild unraveling a novel mechanism of the cAMP-mediated inhibition of leukotriene biosynthesis |
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67. |
human 5-lipoxygenase is inhibited by dihydroxydocosahexaenoic acids of the neuroprotectin D family |
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68. |
CYSLTR2 and ALOX5 polymorphisms may predispose a minority of individuals to excessive cysteinyl-leukotriene concentrations, yielding a distinct asthma phenotype most likely to respond to leukotriene modifier pharmacotherapy. |
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69. |
In silico screening of the whole 5-LO gene area (84 kb, including 10 kb promoter region) was performed and 22 putative vitamin D response elements were identified. |
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70. |
upregulation in glioblastoma multiforme |
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71. |
upregulated in colon cancer; affecting cell survival |
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72. |
LTC4 production by eosinophils in asthmatic subjects with alternative forms of ALOX-5 core promoter |
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73. |
determination of binding sites for calcium and magnesium |
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74. |
results suggest that splitting of BL41-E95-A cells induces de novo synthesis of a protein involved in the activation of casp-6 and casp-8, which cleaves 5-LO. |
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75. |
human breast tumours aberrantly express significantly higher levels of 5-lipoxygenase; levels of 5-lipoxygenases were also particularly high in tumours from patients who died of breast cancer. |
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76. |
possible involvement of 5-lipoxygenase (ALOX5) gene polymorphism in ASA-intolerant asthma (AIA) in a Korean population |
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77. |
the GC-rich part of the 5-lipoxygenase gene promoter, including a novel Sp1 site, appear important for basal (rather than upregulated) transcription of 5-lipoxygenase gene in monocytic cells |
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78. |
LOX5 and FLAP pathway in monocytes and microglia yields products toxic toward neurons (neuroblastoma cell line) |
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79. |
PKA phosphorylates 5-LO on Ser-523, which inhibits the catalytic activity of 5-LO and reduces cellular LT generation |
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80. |
Lipoxygenase is induced in bladder cancer. Results suggest that lipoxygenase inhibitors may mediate potent antiproliferative effects against bladder cancer cells. |
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81. |
molecular basis of the specific subcellular localization of the C2-like domain |
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82. |
Expression of 5-lipoxygenase mRNA was observed in muscle tissues from patients with idiopathic inflammatory myopathies suggesting a role in pathogenesis of this disease. |
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83. |
there is no evidence of increased expression of 5-LO mRNA in either quiescent or active stages of inflammatory bowel disease |
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84. |
results suggest that 5-lipoxygenases is up-regulated in colorectal cancer and that inhibition of its expression might be valuable in the prevention and treatment of colorectal cancer |
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85. |
Nuclear export of 5-LO depends on the stress-induced activation of the p38 MAPK pathway. |
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86. |
Increased 5-lipoxygenase expression is associated with esophageal cancer |
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87. |
the polymorphism of ALOX5 at positions of -1708 G > A showed significant difference in genotype frequency between aspirin-intolerant urticaria and aspirin-intolerant asthma |
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88. |
5-lipoxygenase and leukotriene A4 hydrolase expression in atherosclerotic lesions correlates with symptoms of plaque instability |
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89. |
The stratified squamous epithelial cells from inflamed or hyperplastic tissues of palatine and pharyngeal tonsils (nasopharyngeal-associated lymphoid tissue) express 5-lipoxygenase protein. |
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90. |
platelet-stimulated proliferation of fibroblasts is mediated by an increased 5-LO activity |
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91. |
The data did not support a significant effect of ALOX5-promoter polymorphism on MI risk. |
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92. |
5-Lipooxygenase up-regulation is an important step in renal cancer progression. |
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93. |
Data show that the previously identified bipartite-motif region within 5-lipoxygenase is not a functional import sequence, whereas the newly identified basic region constitutes a true nuclear import sequence. |
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94. |
polymorphisms in arachidonate 5-lipoxygenase is associated with colon cancer risk |
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95. |
Administration of omega-3 reduced significantly ALOX5 activity, with no effect on ALOX5 protein expression. |
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96. |
no significant associations of the 2 5-LOX polymorphisms with the risk of colorectal adenoma |
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97. |
CON6 mouse point mutations (I645V and V646I) as well as the double mutant (I645V+V646I) introduced by site-directed mutagenesis into human 5-LO exhibited reduced catalytic activities but retained their positional specificity & substrate affinity. |