1: FOS FBJ murine osteosarcoma viral oncogene homolog [ Homo sapiens ]

GeneID: 2353 updated 25-Nov-2009

[Top][Help]Summary

Official Symbol
FOSprovided by HGNC
Official Full Name
FBJ murine osteosarcoma viral oncogene homologprovided by HGNC
Primary Source
HGNC:3796
See related
Ensembl:ENSG00000170345; HPRD:01275; MIM:164810
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AP-1; C-FOS; FOS
Summary
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq]

[Top][Help]Genomic regions, transcripts, and products

(plus) Go to reference sequence detailsTry our new Sequence Viewer


[Top][Help]Genomic context

chromosome: 14; Location: 14q24.3See FOS in MapViewer

[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into Function What's a GeneRIF?

PubMed 1. HNRNPR enhanced transcription from the c-fos promoter.
PubMed 2. Data suggest that c-fos may play a role in the molecular mechanisms of estrogen action on the induction, promotion or progression of endometriosis.
PubMed 3. Report FOS proliferating network construction in early colorectal cancer (CRC) based on integrative significant function cluster and inferring analysis.
PubMed 4. study found surface parameters for Fra-1 are similar in general to those of c-Fos and c-Jun; differences were found in the interactions of the three proteins with phospholipids
PubMed 5. the role of calmodulin in PACAP-induced FOS gene expression
PubMed 6. AP-1 proteins (jun/fos) are differentially expressed in ovarian tumors of differing malignant potential. No correlation with the proliferative and invasive potential of ovarian cancer cell lines could be found.
PubMed 7. Data suggest that the single nucleotide variants of the TGACTCA motif modulate energetics and orientation of binding of the Jun-Fos heterodimer and that such behavior may be a critical determinant of differential regulation of specific genes.
PubMed 8. Promoter analysis showed that PRIP acted through serum-responsive factor to regulate FOS gene expression.
PubMed 9. Trolox prevents osteoclast formation and bone loss by inhibiting both RANKL induction in osteoblasts and c-Fos expression in osteoclast precursors.
PubMed 10. These results indicate that the rat model shows symptoms similar to those in patients with orofacial cancer, for example, induction of feeding disorder and neuropathic pain.
PubMed 11. c-Fos is a requisite and specific component for inducible NOS2 expression
PubMed 12. LPS-induced c-fos and c-jun expressions are mediated by two different signaling pathways: one through phosphoinositide-phospholipase C, and the second through activation of protein kinase A (PKA).
PubMed 13. c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1.
PubMed 14. confirmed the downregulation of the FOS-JUNB pathway at transcriptional and protein level
PubMed 15. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
PubMed 16. The SAF-1.c-Fos.c-Jun ternary complex efficiently promotes transcription from both SAF-1 and AP-1 sites of human MMP-1 promoter.
PubMed 17. the enhanced ability of tumor-derived LMP1 to induce and stabilize the c-Fos oncogene can be localized to two amino acids in the C terminus of LMP1
PubMed 18. bexarotene increased the occupancy of the identified enhancer element in IGFBP-6 gene by RXRalpha, RARbeta, cJun, cFos, and p300
PubMed 19. both SF1 and LRH1 can transcriptionally cooperate with the AP-1 family members c-JUN and c-FOS, known to be associated with enhanced proliferation of endometrial carcinoma cells, to further enhance activation of the STAR, HSD3B2, and CYP19A1 PII promoters
PubMed 20. Activator protein-1 and smad proteins synergistically regulate human follicle-stimulating hormone beta-promoter activity.
PubMed 21. Overexpression experiments implicate AP-1 family member Fra-1 in regulation of matrix metalloproteinase-1 expression in myeloid cells during inflammation.
PubMed 22. Peptidylarginine deiminase Intergenic Enhancer is a strong enhancer of the PADI3 promoter in Ca2+-differentiated epidermal keratinocytes, and requires bound
PubMed 23. The thermodynamics of heterodimerization of leucine zippers of Jun and Fos was characterized.
PubMed 24. Expression of c-fos in the human endometrium may be regulated by 17beta-E(2), and c-fos may be involved in development of endometriosis by promoting MMP-9 gene expression and subsequently the invasive potential of endometrial explants.
PubMed 25. Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope.
PubMed 26. loss of c-Fos expression is associated with tumour progression in ovarian carcinoma and that c-Fos may be a prognostic factor
PubMed 27. identify c-JUN and c-FOS as important regulators of human replication origin selection
PubMed 28. FOS-related genes, which have been implicated in early hypoxia as well as the development of breast cancers, were differentially expressed before and after surgery.
PubMed 29. Thrombin also stimulated the expression of c-fos in GFs within 1 hour of exposure. The stimulation of c-fos mRNA expression by thrombin can be attenuated by D-Phe-Pro-ArgCH(2)Cl, a serine-proteinase inhibitor.
PubMed 30. Results describe the effects of estradiol on cyclin D1, PS2, and c-fos gene expression by measuring levels of RNA polymerase II on DNA templates, levels of nascent transcripts associated with RNA polymerase II, and levels of RNAs.
PubMed 31. FRA2 and AP1 have roles in development of pulmonary fibrosis
PubMed 32. GPR30-mediated inhibition of urothelial cell proliferation is the result of decreased cyclin D1 by down-regulation of activation protein-1 signaling.
PubMed 33. an unexpected function for c-Fos as a direct regulator of Tcrb recombination, rather than its usual function as a transcription regulator.
PubMed 34. Results suggest that ganoderic acids-A and -H mediate their biological effects through the inhibition of AP-1 and NF-kappaB, resulting in the down-regulation of expression of Cdk4 and the suppression of secretion of uPA, respectively.
PubMed 35. Binding of Fos-Jun bZIP domains to both tetradecanoylphorbol acetate (TRE) and CRE response elements is under enthalpic control and accompanied by entropic penalty at physiological temperatures.
PubMed 36. These data demonstrate the role of Cx43 in the proliferation and migration of human saphenous vein smooth muscle cells and angiotensin II-induced Cx43 expression via mitogen-activated protein kinases (MAPK)-AP-1 signaling pathway.
PubMed 37. vFLIP suppresses the AP-1 pathway, which is essential for KSHV lytic replication, by activating the NF-kappaB pathway.
PubMed 38. These results demonstrated that D-alpha-tocopherol may be able to prevent the IL-8 upregulation and the increase in AP-1 activation induced by UVA irradiation through down-modulating cellular oxidative stress.
PubMed 39. These results suggest that promotion of endothelial migration and proliferation by Ang-1 is mediated, in part, through the production of IL-8, which acts in an autocrine fashion to suppress apoptosis and facilitate cell proliferation and migration.
PubMed 40. The present data indicate that bovine dialyzable leukocyte extract can block the AP-1 DNA-binding activity and expression of several transcriptions factors in breast cancer cells.
PubMed 41. A loss of c-fos expression is correlated with a more advanced stage, lymph node metastasis, lymphatic invasion and shorter survival in gastric carcinoma.
PubMed 42. AP-1 plays an essential role in the growth of at least some of NSCLC cells.
PubMed 43. The physical interaction of AP-1 with p22(phox) gene promoter facilitates NADPHox regulation.
PubMed 44. Coordinated down- and up-regulation of the various AP-1 subunits in the course of epidermal wound healing is important for its undisturbed progress, putatively by influencing inflammation and cell-cell communication.
PubMed 45. Ras/MAPK cascade acts as the upstream signaling for AP-1 activation and IL-8 expression in toxin A-stimulated intestinal epithelial cells.
PubMed 46. Observational study of gene-disease association. (HuGE Navigator)
PubMed 47. c-Fos may undergo cell cycle dependent phosphorylation, in which some kinases including Aurora-A play a role in catalyzing the post translational modification of c-Fos.
PubMed 48. VEGF, p-IkappaB-alpha, NF-kappaB, c-FOS, p-c-JUN, EGF-R and COX-2 were expressed in stromal myofibroblasts surrounding colon adenocarcinomas in the majority of cases.
PubMed 49. Dimerization with the Jun proteins inhibits c-Fos nuclear exit.
PubMed 50. In the paraventricular nucleus anandamide and N-arachidonoyl-serotonin increased significantly c-Fos expression. In the arcuate nucleus only OMDM-1 increased c-Fos expression.
PubMed 51. Amino acid residues required for physical and cooperative transcriptional interaction of STAT3 and AP-1 proteins c-Jun and c-Fos.
PubMed 52. During mitosis, HSF2 is bound to the HSE promoter elements of other heat shock genes, including hsp90 and hsp27, and the proto-oncogene c-fos. The presence of HSF2 is important for expression of these genes.
PubMed 53. c-fos expression in the medial geniculate body triggered by cortical activation is elicited via a direct corticothalamic pathway, not by the pathway through the thalamic reticular nucleus.
PubMed 54. These data indicate that the aberrant expression of PTEN contributes to the activation of the PI3kinase/Akt pathway and its transcription factor mediators in glioma.
PubMed 55. Phosphorylation of the carboxy-terminal transactivation domain of c-FGOS by extracellular signal-related kinase mediates the transcriptional activation of AP-1 and cellular neoplastic transformation by PDGF.
PubMed 56. SDF-1/CXCL12 enhanced cell survival in synergy with other cytokines involves activation of CREB and induction of Mcl-1 and c-Fos
PubMed 57. Up-regulation of c-Fos in the lymphocytes of rheumatoid arthritis patients.
PubMed 58. VEGF and PlGF induced expression of both full-length FosB mRNA and an alternatively spliced variant.
PubMed 59. In psoriatic epidermis, c-Jun expression was prominent in both hyperproliferating basal and suprabasal keratinocytes, whereas c-Fos expression was unchanged.
PubMed 60. Effects of fluid shear stress on expression of proto-oncogenes c-fos and c-myc in cultured human umbilical vein endothelial cells.
PubMed 61. p53 and c-fos are significantly overexpressed in thyroid cancer patients, indicating their role in the genetic mechanisms leading to thyroid tumorigenesis
PubMed 62. loss of Net and constitutive c-fos expression appear to be a key event in the transformation of cervical cancer cells.
PubMed 63. c-fos and AP-1 are regulated by JNK and p38 MAPK
PubMed 64. c-Fos/c-Jun AP-1 dimer activity is downregulated by SUMO-1, SUMO-2, and SUMO-3
PubMed 65. Vasoactive intestinal peptide induces FOS expression in a prostatic neoplasm cell line.
PubMed 66. studies suggest that the cooperative interaction of the estrogen receptor with Fos and Jun proteins helps confer estrogen responsiveness to the endogenous progesterone receptor gene
PubMed 67. results suggest that Hic-5 participates in the transcriptional regulation of c-fos as a scaffold in transcriptional complexes
PubMed 68. FOS is the primary target of up-regulation in Helicobacter pylori infections in human gastric cancer cells.
PubMed 69. AP-1 and JNK have roles in reactive oxygen species activation in tobacco-induced mucin production in lung cells
PubMed 70. TBP affects the NF1 and c-fos promoters in a manner reciprocal to that of TLF, stimulating the c-fos promoter and inhibiting NF1 transcription
PubMed 71. Results showed that certain regulation involved in c-myc, c-fos, and c-jun was present in the apoptosis, and the c-Myc dependent-on and Jun N-terminal kinase (JNK) pathway also play roles.
PubMed 72. The increase in c-Fos-immunoreactive neurons induced by butyric acid was reproduced with hydrochloric acid at the same pH but not with sodium butyrate.
PubMed 73. data demonstratre that c-Fos physically and functionally interacts with JCV major early regulatory protein large T-Ag and that this interaction modulates JCV transcription and replication in glial cells
PubMed 74. expression of Egr-1, c-fos and cyclin D1 varies in esophageal precancerous lesions and cancer tissues, suggesting an involvement of these genes in the development of esophageal carcinoma.
PubMed 75. independent and cooperative activation of chromosomal c-fos promoter by STAT3
PubMed 76. c-Fos produced in D1 receptor-expressing neurons integrates mechanisms to facilitate both the acquisition and extinction of cocaine-induced persistent changes in brains of Drd-1-Cre transgenic mice.
PubMed 77. Tumor promoter arsenite stimulates histone H3 phosphoacetylation of this and c-jun proto-oncogene chromatin in diploid fibroblasts.
PubMed 78. a physical interaction between c-Fos and STAT-1 participates in NOS2 gene transcriptional activation in lung epithelium
PubMed 79. candidate genes that may be involved in the origination of ameloblastoma and several genes previously unidentified in relation to human tooth development.
PubMed 80. p38alpha and -beta mediate UV-induced, AP-1-mediated, c-Fos phosphorylation
PubMed 81. Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex
PubMed 82. Analysis of heterophilic and homophilic interactions of cadherins using the c-Jun/c-Fos dimerization domains
PubMed 83. In hepatoma-associated anorexia-cachexia c-Fos was induced in several brain areas of thes forebrain.
PubMed 84. Sustained ERK5 activity and the E3 ligase UBR1 regulate the stability and subcellular localization of c-Fos.
PubMed 85. c-jun, junD, junB, and c-fos and Notch2 are expressed in splenic marginal zone lymphoma
PubMed 86. c-Fos binding at the TGFbeta1 promoter proximal AP-1 site in human colon carcinoma cells is required for TGFbeta1 production by the tumor cells.
PubMed 87. RET(Y791F) and RET(S891A) induce STAT3 Ser(727) phosphorylation via a canonical Ras/ERK1/2 pathway and integration of the Ras/ERK1/2/ELK-1 and STAT3 pathways was required for up-regulation of the c-fos promoter by FMTC-RET
PubMed 88. Review. AP1 plays a crucial role during human papillomavirus (HPV) early gene expression, in particular of the expression of E6 and E7 oncoproteins.
PubMed 89. The positive c-fos immunoreactivity observed in sudden infant death syndrome suggests that the neurons of the dorsal motor vagal nucleus involved in the regulation of breathing are able to yield an intense, immediate ventilatory response to hypoxia.
PubMed 90. INI1/hSNF5/BAF47 could be recruited to the region of c-fos promoter to reduce histone acetylation
PubMed 91. Expression of c-fos was induced by TPA and Saikosaponin a during 30 min to 6 h of treatment.
PubMed 92. c-Fos proto-oncoprotein is degraded by the proteasome independently of its own ubiquitinylation
PubMed 93. phosphorylation of tyrosine residues 10 and 30 of c-Fos regulate the rate of synthesis of phospholipids by regulating c-Fos/endoplasmic reticulum association.
PubMed 94. Bombesin antagonists inhibit growth of MDA-MB-435 estrogen-independent breast cancers and decrease the expression of the ErbB-2/HER-2 oncoprotein and c-jun and c-fos oncogenes
PubMed 95. activity of the AP-1 components c-Jun, ATF2, and c-Fos is altered in renal cystic tissue of patients with autosomal dominant polycystic kidney disease
PubMed 96. PGE2 increases the expression and secretion of VEGF in HCC cells by activating the transcription factor c-fos, promotes the angiogenesis of hepatocellular carcinoma and plays an important role in the pathogenesis of liver cancer.
PubMed 97. c-Fos represents a novel target for the isomerizing activity of Pin1, which has a role in the mechanism by which c-Jun and c-Fos cooperate to regulate AP-1-dependent gene transcription
PubMed 98. Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promotor (transcription factor AP1)
Submit: New GeneRIF Correction

[Top][Help]HIV-1 protein interactions

Protein    Interaction
1. Envelope surface glycoprotein gp120 Treatment of cells with HIV-1 gp120 induces increased levels of endogenous c-fos and c-jun mRNA and proteins, an activation of both c-fos and c-jun promoters, and a very rapid stimulation of the MAPK/ERK pathway PubMed
2. HIV-1 envelope protein gp120 is able to induce COX-2 mRNA and protein in human neuroblastoma cell lines that express CXCR4 and CCR5 but not CD4; gp120 induces COX-2 promoter transcription through NF-kappaB and activating protein-1 (AP-1) sites PubMed
3. Binding of heat-inactivated HIV-1 (iHIV-1) or HIV-1 gp120 to infected resting PBMCs is sufficient to activate NF-kappa B and AP-1, to induce cell surface expression of CD25, and to commit cells to produce virus PubMed
4. HIV-1 gp120 and anti-CD4 antibodies induce a specific, significant decrease in the binding activity of NF-AT, NF-kappa B and AP-1, which leads to an inhibition of IL-2 production and cell proliferation PubMed
5. Envelope surface glycoprotein gp160, precursor HIV-1 gp160 induces activation of transcription factor, activated protein-1 (AP-1), comprised of Fos and Jun proteins, in CD4 positive T cell lines PubMed
6. Nef HIV-1 Nef expression in human (THP-1) monocyte-macrophages induces both DNA binding and transcriptional activities of the activator protein-1 (AP-1) transcription factor, c-fos and c-jun; this induction requires the proline-rich PxxP motif of Nef PubMed
7. HIV-1 Nef inhibits the recruitment of AP-1 DNA binding activity by downregulating the transcription of c-fos in mitogen-stimulated human T cells PubMed
8. Tat HIV-1 Tat upregulates c-Fos expression and c-Fos protein has been shown to be essential for optimal transactivation of the HIV-1 LTR promoter by Tat PubMed
9. HIV-1 Tat expression in Jurkat T cells enhances cooperative NFAT/AP-1- but not AP-1-dependent transcription independent of its ability to transactivate the HIV-1 LTR PubMed
10. HIV-1 Tat contributes to the super-induction of IL-2 promoter activity through transcription factors such as NF-kappaB and AP-1 (c-Jun and c-Fos) PubMed
11. HIV-1 Tat activates the AP-1 complex containing c-fos through a p56lck dependent mechanism PubMed
12. Vpr Synthetic HIV-1 Vpr protein activates AP-1 (Jun/Fos), c-Jun N-terminal kinase (JNK), NF-kappaB, and MKK7 in both U937 cells and primary macrophages. PubMed

Go to the HIV-1, Human Protein Interaction Database

[Top][Help]Interactions

Description ..........
  Product Interactant Other Gene Complex Source Pubs          
An unspecified isoform of EGFR binds to c-fos promoter.
  K00650.1      EGFR      BIND    PubMed
An unspecified isoform of STAT3 binds to c-fos promoter.
  K00650.1      STAT3      BIND    PubMed
Sap-1a is interacts with the serum response element (SRE) of c-fos. This interaction was modeled on a demonstrated interaction between human Sap-1a and c-fos from an unspecified species.
  NC_000014.7   NP_001964.2   ELK4      BIND    PubMed
SRF interacts with the c-fos promoter CArG box. This interaction was modeled on a demonstrated interaction between human SRF and c-fos promoter CArG box from an unspecified species.
  NC_000014.7   NP_003122.1   SRF      BIND    PubMed
KSRP interacts with AREfos. This interaction was modeled on a demonstrated interaction between KSRP from human and AREfos from an unspecified species.
  NM_005252.2   NP_003676.1   KHSRP      BIND    PubMed
 
  NP_005243.1   Activating transcription factor 2   ATF2      HPRD    PubMed
 
  NP_005243.1   NP_006390.1   BATF      HPRD    PubMed
 
  NP_005243.1   NP_005169.1   BCL3      HPRD    PubMed
 
  NP_005243.1   NP_001797.1   CEBPG      HPRD    PubMed
 
  NP_005243.1   NP_056271.2   COBRA1      HPRD    PubMed
 
  NP_005243.1   NP_001886.1   CSNK2A1      HPRD    PubMed
 
  NP_005243.1   NP_001887.1   CSNK2A2      HPRD    PubMed
 
  NP_005243.1   CHOP   DDIT3      HPRD    PubMed
 
  NP_005243.1   ELK 1   ELK1      HPRD    PubMed
 
  NP_005243.1   NP_891548.1   ERG      HPRD    PubMed
 
  NP_005243.1   ETS1   ETS1      HPRD    PubMed
 
  NP_005243.1   TFIIF beta   GTF2F2      HPRD    PubMed
 
  NP_005243.1   Transcription factor 1   HNF1A      HPRD    PubMed
c-Fos interacts with Jagged1 promoter.
  NP_005243.1   AL035456.26   JAG1      BIND    PubMed
cFos interacts with cJun.
  NP_005243.1   NP_002219.1   JUN      BIND    PubMed
c-Jun interacts with c-Fos. This interaction was modelled on a demonstrated interaction between c-Jun from an unspecified species and c-Fos from an unspecified species.
  NP_005243.1   NP_002219.1   JUN      BIND    PubMed
 
  NP_005243.1   c Jun   JUN      HPRD    PubMed
 
  NP_005243.1   Oncogene Jun-B   JUNB      HPRD    PubMed
 
  NP_005243.1   Oncogene Jun-B   JUNB      HPRD    PubMed
 
  NP_005243.1   NP_005345.2   JUND      HPRD    PubMed
 
  NP_005243.1   c-Maf   MAF      HPRD    PubMed
 
  NP_005243.1   MAP3K7   MAP3K7      HPRD    PubMed
 
  NP_005243.1   BAA32288.1   MITF      HPRD    PubMed
 
  NP_005243.1   SRC1   NCOA1      HPRD    PubMed
 
  NP_005243.1   Nuclear receptor corepressor 2   NCOR2      HPRD    PubMed
 
  NP_005243.1   NP_775114.1   NFATC2      HPRD    PubMed
 
  NP_005243.1   NFKB1   NFKB1      HPRD    PubMed
 
  NP_005243.1   PML   PML      HPRD    PubMed
 
  NP_005243.1   Retinoblastoma 1   RB1      HPRD    PubMed
NF-kappa-B interacts with c-Fos.
  NP_005243.1   NP_068810.2   RELA      BIND    PubMed
 
  NP_005243.1   NP_003933.1   RPS6KA4      HPRD    PubMed
 
  NP_005243.1   CBFA2   RUNX1      HPRD    PubMed
 
  NP_005243.1   Runt related transcription factor 2   RUNX2      HPRD    PubMed
 
  NP_005243.1   SMARCD1   SMARCD1      HPRD    PubMed
 
  NP_005243.1   TFIID   TAF1      HPRD    PubMed
 
  NP_005243.1   TATA box binding protein   TBP      HPRD    PubMed
 
  NP_005243.1   GILZ   TSC22D3      HPRD    PubMed
 
  NP_005243.1   Upstream stimulatory factor 2   USF2      HPRD    PubMed
 
  NP_005243.1   BAB82982.1   XBP1      HPRD    PubMed
 
  NP_005243.1   B-ATF        HPRD    PubMed
 
  NP_005243.1   FZA-B        HPRD    PubMed
 
  NP_005243.1   SAP-1a        HPRD    PubMed
 
  NP_005243.1   T antigen        HPRD    PubMed
 
  c-Fos   NP_001964.1   ELK4      HPRD    PubMed
 
  c-Fos   NP_002043.2   GATA4      HPRD    PubMed
Reconstituted Complex
  BioGRID:108636   BioGRID:107776   ATF2      BioGRID    PubMed
Reconstituted Complex; Two-hybrid
  BioGRID:108636   BioGRID:107074   BCL3      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:108636   BioGRID:117421   COBRA1      BioGRID    PubMed
Reconstituted Complex
  BioGRID:108636   BioGRID:107777   CREBBP      BioGRID    PubMed
Far Western; Reconstituted Complex
  BioGRID:108636   BioGRID:107841   CSNK2A1      BioGRID    PubMed
Far Western; Reconstituted Complex
  BioGRID:108636   BioGRID:107842   CSNK2A2      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:108636   BioGRID:108016   DDIT3      BioGRID    PubMed
Reconstituted Complex
  BioGRID:108636   BioGRID:108415   ETS2      BioGRID    PubMed
Reconstituted Complex
  BioGRID:108636   BioGRID:109216   GTF2E2      BioGRID    PubMed
Reconstituted Complex
  BioGRID:108636   BioGRID:109217   GTF2F1      BioGRID    PubMed
Reconstituted Complex
  BioGRID:108636   BioGRID:109218   GTF2F2      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:108636   BioGRID:112789   HNF1A      BioGRID    PubMed
Co-crystal Structure; Reconstituted Complex; Two-hybrid
  BioGRID:108636   BioGRID:109928   JUN      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:108636   BioGRID:110432   MITF      BioGRID    PubMed
Reconstituted Complex
  BioGRID:108636   BioGRID:110748   NACA      BioGRID    PubMed
Reconstituted Complex; Two-hybrid
  BioGRID:108636   BioGRID:114200   NCOA1      BioGRID    PubMed
Reconstituted Complex
  BioGRID:108636   BioGRID:116691   NCOA6      BioGRID    PubMed
Reconstituted Complex; Two-hybrid
  BioGRID:108636   BioGRID:114974   NCOR2      BioGRID    PubMed
Reconstituted Complex
  BioGRID:108636   BioGRID:111384   PML      BioGRID    PubMed
Phenotypic Enhancement; Two-hybrid
  BioGRID:108636   BioGRID:111902   RELA      BioGRID    PubMed
Biochemical Activity
  BioGRID:108636   BioGRID:114468   RPS6KA4      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:108636   BioGRID:107309   RUNX1      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex; Two-hybrid
  BioGRID:108636   BioGRID:107308   RUNX2      BioGRID    PubMed
Reconstituted Complex; Two-hybrid
  BioGRID:108636   BioGRID:110263   SMAD3      BioGRID    PubMed
Reconstituted Complex
  BioGRID:108636   BioGRID:112566   SPI1      BioGRID    PubMed
Reconstituted Complex
  BioGRID:108636   BioGRID:112735   TAF1      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:108636   BioGRID:112771   TBP      BioGRID    PubMed
Reconstituted Complex
  BioGRID:108636   BioGRID:108165   TSC22D3      BioGRID    PubMed
Reconstituted Complex
  BioGRID:108636   BioGRID:113264   VDR      BioGRID    PubMed
Reconstituted Complex
  BioGRID:108636   BioGRID:113331   XBP1      BioGRID    PubMed

[Top][Help]General gene information

Markers

WI-19801(e-PCR)
Links: UniSTS:18950
Fos(e-PCR), detects polymorphism
Links: UniSTS:143125
STS-V01512(e-PCR)
Links: UniSTS:8984
G06585(e-PCR)
Links: UniSTS:62751
PMC139817P1(e-PCR)
Links: UniSTS:270898
BP250015A10G9(e-PCR)
Links: UniSTS:519218
BP240034A10G4(e-PCR)
Links: UniSTS:519219
PMC151710P2(e-PCR)
Links: UniSTS:271168
FOS(e-PCR)
Links: UniSTS:497790
GDB:199085(e-PCR)
Links: UniSTS:156050
PMC86910P1(e-PCR)
Links: UniSTS:273555
GDB:201707(e-PCR)
Links: UniSTS:156053
PMC135937P1(e-PCR)
Links: UniSTS:270779
PMC87308P1(e-PCR)
Links: UniSTS:273595
PMC126057P3(e-PCR)
Links: UniSTS:270524
FOS_V40(e-PCR)
Links: UniSTS:477415

Homology

Homologs of the FOS gene The FOS gene is conserved in chimpanzee, dog, cow, mouse, rat, and zebrafish.


Map Viewer (Mouse, Rat)

Pathways

KEGG pathway: B cell receptor signaling pathway
04662
KEGG pathway: Colorectal cancer
05210
KEGG pathway: MAPK signaling pathway
04010
KEGG pathway: Pathways in cancer
05200
KEGG pathway: T cell receptor signaling pathway
04660
KEGG pathway: Toll-like receptor signaling pathway
04620

[Top][Help]General protein information

Preferred Names
v-fos FBJ murine osteosarcoma viral oncogene homolog
Names
v-fos FBJ murine osteosarcoma viral oncogene homolog
activator protein 1
cellular oncogene c-fos
FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

  1. NM_005252.3 → NP_005243.1  v-fos FBJ murine osteosarcoma viral oncogene homolog

    Source sequence(s)
    AF111167,AK291326
    Consensus CDS
    CCDS9841.1
    UniProtKB/Swiss-Prot
    P01100
    UniProtKB/TrEMBL
    Q6FG41
    Conserved Domains (1) summary
    cl02576
    Location:147 – 185
    Blast Score: 133
    bZIP_1; bZIP transcription factor

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000014.8

    Range
    75745530..75748912
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NT_026437.12 

    Range
    56745530..56748912
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

  1. AC_000057.1

    Range
    55783616..55786998
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_925561.1 

    Range
    22538146..22541528
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

  1. AC_000146.1

    Range
    55913974..55917356, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_001838113.2 

    Range
    19991185..19994567, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

  Nucleotide   Protein
  genomic   AB022275.1   BAA87920.1
  genomic   AB022276.1   BAA87921.1
  genomic   AF111167.2   AAC98315.1
  genomic   AY212879.1   AAO21129.1
  genomic   CH471061.1   EAW81227.1
       EAW81228.1
       EAW81229.1
  genomic   K00650.1   AAA52471.1
  genomic   V01512.1   CAA24756.1
  mRNA   AK097379.1   BAG53458.1
  mRNA   AK290907.1   BAF83596.1
  mRNA   AK291326.1   BAF84015.1
  mRNA   AK298659.1   BAG60827.1
  mRNA   BC004490.2   AAH04490.1
  mRNA   BX647104.1   None
  mRNA   CR541785.1   CAG46584.1
  mRNA   CR542267.1   CAG47063.1
  mRNA   CR612516.1   None
  mRNA   CR620080.1   None
  other-genetic   DQ893444.2   ABM84370.1
  other-genetic   DQ896750.2   ABM87749.1
Protein Accession   Links
P01100.1   GenPept   UniProtKB/Swiss-Prot:P01100
Q6FG41   GenPept   UniProtKB/TrEMBL:Q6FG41
Q76MY9   GenPept   UniProtKB/TrEMBL:Q76MY9
Q76MZ0   GenPept   UniProtKB/TrEMBL:Q76MZ0

[Top][Help]Additional Links