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1. |
Mechanical force applied to filamin can expose cryptic integrin binding sites. |
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2. |
These findings support a role for FLNa-beta1 integrin as a mechanosensitive complex that bidirectionally senses the tension of the matrix and, in turn, regulates cellular contractility and response to this matrix tension. |
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3. |
propose that binding of pro-PrP to FLNa perturbs FLNa function, thus contributing to the aggressiveness of pancreatic ductal adenocarcinoma |
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4. |
High plasma filamin A is associated with high-grade astrocytoma and metastatic breast cancer. |
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5. |
Wnt5A activates calpain-1, leading to the cleavage of filamin A, which results in a remodeling of the cytoskeleton and an increase in melanoma cell motility |
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6. |
The interaction between FilGAP and FlnA plays a role in protecting cells against force-induced apoptosis. |
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7. |
Mutational analysis informed by structure can generate reagents for probing specific cellular interactions of filamin A (FLNa). Disease-related FLNa mutations have demonstrable effects on FLNa function |
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8. |
Filamin A modulates kinase activation and intracellular trafficking of epidermal growth factor receptors in human melanoma cells. |
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9. |
This study reports the structure of FLNa domain 24 (FLNa24), compare the structure with FLNc24, and discuss how dimerization is formed in FLNa24. |
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10. |
FLNA genes in cell cycle control and lipid metabolism with dynamically regulated binding sites for sterol regulatory element-binding protein 1 and RNA polymerase II in HepG2 cells |
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11. |
Our report also helps define the critical region with exclusion of FLNA in the X-linked mental retardation phenotype. |
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12. |
analysis of the migfilin-filamin interaction and competition with integrin beta 7 tails |
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13. |
ASB2 may regulate hematopoietic cell differentiation by modulating cell spreading and actin remodeling through targeting of filamins A and B for degradation. |
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14. |
role of filamin cleavage and protein tyrosine phosphorylation in shear-stress-induced platelet microparticle formation and of its suppression by the monoclonal antibody (mAb) Ib-23 directed against GPIbalpha |
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15. |
mutant FLA lacking the actin binding domain is capable of restoring almost as well as full length FLA the down-regulation of the human mu opioid receptor. Some functions of FLA do not act via the actin cytoskeleton. |
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16. |
These data indicate that caveolin-1 specifies filamin A as a novel target for Akt-mediated filamin A Ser-2152 phosphorylation thus mediating the effects of caveolin-1 on IGF-I-induced cancer cell migration. |
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17. |
Datas suggest that filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 to locally influence the dynamics of actin cytoskeletal structures at lamellipodia to promote cell movement. |
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18. |
Characterize a novel cell surface protein ECSM2 that regulates endothelial chemotaxis and tube formation, and interacts with filamin A. |
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19. |
novel mutation, c.987G-->C mutation in exon 6 of the Filamin A (FLNA) gene in the genomic DNA in bilateral periventricular nodular heterotopia |
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20. |
Filamin A plays a pivotal role in FcgammaRI surface expression via retention of FcgammaRI from a default lysosomal pathway. |
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21. |
Review explores the pathogenesis of persistent periventricular nodular heterotopia with respect to filamin-A (FLNa) mutations with mouse models. [review] |
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22. |
in the absence of filamin A, chronic treatment with morphine, methadone or levorphanol leads to up-regulation of mu opioid receptor |
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23. |
A library of FLNa fragments was generated to examine their F-actin binding to define the structural properties of FLNa that enable its various functions. |
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24. |
analysis of filamin a IgFLN domains suggests that auto-inhibition by adjacent IgFLN domains may be a general mechanism controlling filamin-ligand interactions. |
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25. |
FlnA restored Casodex anticaner sensitivity in C4-2 prostatic cancer cells by decreasing Akt phosphorylation. |
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26. |
Essential for both the efficient signaling and sequestration of dopamine D3 receptor. |
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27. |
Filamin-A as an adaptor protein that links HIV-1 receptors to the actin cytoskeleton remodelling machinery, which may facilitate virus infection. |
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28. |
calmodulin and calcium regulate the binding of filamin A to actin filaments |
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29. |
3 filamin A mutations were identified in periventricular heterotopia/Ehlers-Danlos patients: a 2762 delG, a C116 point mutation causing A39G, & a 4147 delG. |
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30. |
Periventricular nodular heterotopia caused by FLN1 mutations in men has a wide clinical spectrum and is caused by different genetic mechanisms, including somatic mosaicism. |
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31. |
PH domain of ROCK binds to the carboxy-terminal region of filamin-A containing the last 24th repeat. ROCK co-localized with filamin-A at the protrusive cell membranes of HeLa cells. |
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32. |
filamin-A was found to have no effect on Kir2.1 channel behavior but, rather, increased the number of functional channels resident within the membrane |
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33. |
filamin A has a role in signaling pathways that mediate organogenesis in multiple systems during embryonic development |
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34. |
expression of FLNa regulates constitutive activation of the Ras/ERK pathway partly through a Ras-GRF1 mechanism to modulate the production of MMP-9. |
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35. |
FLNa may be essential for Pak1-induced cytoskeletal reorganization |
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36. |
D3R, filamin A, and beta-arrestin form a signaling complex that is destabilized by agonist- or expression-mediated increases in GRK2/3 activity |
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37. |
G12, Rho, filamin-A, and the actin cytoskeleton are required for amino acid-stimulated Ca2+ oscillations produced by the Ca2+-sensing receptor |
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38. |
Data provide substantial evidence that ribosomal S6 kinase (RSK) phosphorylates filamin A, and suggest a novel role for RSK in the regulation of the actin cytoskeleton. |
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39. |
Data indicate that filamin A binding to CD28 is required to induce the T-cell cytoskeletal rearrangements leading to recruitment of lipid microdomains and signalling mediators into the immunological synapse. |
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40. |
shear-dependent VWF-induced platelet activation affects filamin A binding to GpIb-IX-V, and filamin A binding to the cytoplasmic tail of GpIbalpha regulates proaggregatory tyrosine kinase signaling. |
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41. |
A purified C-terminal region of filamin is a suitable substrate for calcineurin in vitro and in vivo |
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42. |
beta-arrestins and FLNA cooperate to regulate ERK activation and actin cytoskeleton reorganization. |
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43. |
Filamin A is mutated in X-linked chronic idiopathic intestinal pseudo-obstruction with central nervous system involvement. |
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44. |
Two new pedigrees of bilateral periventricular nodular heterotopia are reported with a mutation of FLN1 and a deletion in its C-terminus causing a distal protein truncation. |
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45. |
A woman with complex partial seizures and periventricular nodular heterotopia (PNH) had an amino acid exchange, a transition of guanine to adenine at the first position of intron 13 (IVS13 + 1 G -> A) causing a splice site mutation (2022 + 1 G -> A) |
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46. |
Dual phenotype of periventricular nodular heterotopia and frontometaphyseal dysplasia in one patient is caused by two functionally different, aberrant filamin A proteins |
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47. |
an important role for filamin in the endocytic sorting and recycling of the internalized CTR |
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48. |
Cell death and mechanoprotection by filamin a in connective tissues after challenge by applied tensile forces |
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49. |
Interaction of filamin A with the insulin receptor alters insulin-dependent activation of the mitogen-activated protein kinase pathway. |
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50. |
familial Ehlers-Danlos syndrome and periventricular nodular heterotopia is associated with an amino acid substition sssisns FLNA. |
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51. |
there is a mechanically coupled transcriptional circuit from p38 that induces filamin-A expression [filamin A] |
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52. |
FLNA has diverse roles in embryonic, fetal and postnatal development [review] |
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53. |
Filamin-A interacts with c-mip/Tc-mip in a new T-cell signaling pathway. |
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54. |
Mutations in FLNA result in frontometaphyseal dysplasia and phenotypic diversity. |
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55. |
filamin A is the first gene known to cause isolated nonsyndromic valvular heart disease. |
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56. |
In cells, filamin A tethered plasma membrane CFTR to the underlying actin network. This interaction stabilized CFTR at the cell surface and regulated the plasma membrane dynamics and confinement of the channel. |
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57. |
Our results suggest a role for cyclin B1/Cdk1 in FLNa-dependent actin remodelling. |
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58. |
FLNa interfered with androgen receptor (AR) interdomain interactions and competed with the coactivator transcriptional intermediary factor 2 to specifically down-regulate AR function. |
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59. |
Filamin A binding to PSMA reduces the internalization rate of PSMA and its N-acelylated-alpha linked-acidic dipeptidase activity. |
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60. |
Filamin A was identified as a direct binding partner of protein kinase Calpha; two binding sites were identified on filamin A; a Ca2+ and phospholipid-dependent association of the regulatory domain of protein kinase C with these sites was revealed. |
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61. |
Interaction with filamin A increases cellular CaR by preventing CaR degradation, thereby facilitating CaR signaling. |
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62. |
filamin-A has a role in the recovery from G2 arrest and subsequent mitotic cell death after DNA damage |
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63. |
FLN1 mutations may have a role in periventricular heterotopia |
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64. |
A novel role is revealed for filamin A in the T cell receptor/CD28 signaling pathway leading to transcription factor activation and interleukin-2 production via the inducible interaction with protein kinase C theta. |
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65. |
This suggests that the titin Z2-Zis1 domain can link filamins and alpha-actinin together in the periphery of the Z-line/dense bodies in a fashion that is conserved in smooth and striated muscles. |
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66. |
A novel mutation, 629G>T, in FLNA that had arisen de novo in the mother lead to Otopalatodigital syndrome type 2. |