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1. |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
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exhibits polymorphisms in Systemic lupus erythematosus patients |
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FcgammaRIIb SNP 187-Ile/Thr may influence the Rheumatoid Arthritis phenotypes in Taiwanese RA. |
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Only FCGR3A, FCGR2C and FCGR3B show copy number variation, in contrast to FCGR2A and FCGR2B. |
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The inhibitory signaling abnormality of CD32 possibly contributes to the mechanism of hyperactivity of human SLE B cells. |
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FcgammaRIIa-H/H131 genotype and H131 allele is at higher frequency in Fulani ethnic group; H/H131 genotype was associated with higher levels anti-malarial IgG2 and IgG3 antibodies, and R/R131 genotype was associated with higher levels of IgG1 antibodies |
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The inhibitory FcgammaRIIB is impaired at a critical B cell differentiation checkpoint in Chronic inflammatory demyelinating polyneuropathy. |
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Neither activating receptors FcgammaRI and FcgammaRIII, nor FcgammaRIIB, all of which lack Phe(163), bound the peptide |
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association of the 232T allele with periodontitis might be related to lower levels of antibody response to Porphyromonas gingivalis |
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10. |
This is a report about a spurious (reitered) association between FCGR2B genetic polymorphisms and systemic lupus erythematosus. |
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Results identify FcgammaRIIB as a marker of human metastatic melanoma that impairs the tumor susceptibility to FcgammaR-dependent innate effector responses. |
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Activation of human peripheral IgM+ B cells is transiently inhibited by BCR-independent aggregation of Fc gammaRIIB |
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role of FcgammaRIIB and FcgammaRIIIA gene in susceptibility to systemic lupus erythematosus and to examine possible susceptible haplotypes between two genes |
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14. |
Helicobacter pylori eradication shifts monocyte Fcgamma receptor balance toward inhibitory FCGR2B in immune thrombocytopenic purpura patients. |
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15. |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
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16. |
Observational study and meta-analysis of gene-disease association. (HuGE Navigator) |
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17. |
Observational study of genotype prevalence. (HuGE Navigator) |
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18. |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
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19. |
Observational study of gene-disease association. (HuGE Navigator) |
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20. |
We demonstrate that the expression of the inhibitory receptors Fc gamma RII and CR1 is up-regulated on peripheral memory B cells of healthy controls, whereas this up-regulation is considerably impaired on the memory B cells of SLE patients. |
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RA patients do not fail to up-regulate FcgammaRIIb upon synovial inflammation, but suggests that the balance between expression of the inhibitory FcgammaRIIb and activating FcgammaRs may be in favour of the latter throughout the disease course |
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22. |
Selective blockade of the inhibitory Fcgamma receptor (FcgammaRIIB) in human dendritic cells and monocytes induces a type I interferon response program. |
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23. |
The researchers evidence of altered gene expression in the FCGR2B gene after both aerobic and exhaustive exercise. |
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immature MPC-1- myeloma cells expressed CD32 more weakly than mature, MPC-1+ cells; Myeloma cells lacking CD19 expression are less sensitive to CD32-mediated growth suppression than are CD19+ normal plasma cells. |
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association of a new polymorphism of FCGR2B (I232T) with susceptibility to SLE in the Japanese. |
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26. |
Signals underlying FcgammaRIIB-driven apoptosis are dependent on disruption of mitochondrial potential. |
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27. |
Unlike the Fc gamma RIIa receptor isoform, expression of Fc gamma RIIb is not detected in extracts of cultured human skin mast cell preparations. |
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28. |
FCGR2B expression is patently reduced in mature DCs, and is modulated by treatment with cytokines. The regulated expression of activating and inhibitory FcgRs in DCs emerges as a critical checkpoint in the process of Ag uptake and cross-presentation. |
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29. |
hypothesized that inhibitory signaling through FcgammaRIIb would be counter-productive in germinal center cells undergoing selection by affinity maturation |
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30. |
results indicated that the presence of CD72-*2 allele decreases risk for human systemic lupus erythematosus conferred by FCGR2B-232Thr, possibly by increasing the AS isoform of CD72 |
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31. |
The FcgammaRIIb transmembrane polymorphism is a strong disease susceptibility candidate in epistasis with other genetic effects in Taiwanese and other Asian populations. |
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32. |
FCGR2B 695T>C polymorphism is a critical determinant of severity in rheumatoid arthritis and is a potential therapeutic target. |
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33. |
The differential activity of FCGR2B alleles suggests a novel mechanism of FcgammaRIIb regulation that may influence the risk of autoimmune disease. |
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34. |
FcgammaRIIbl and b2 are both functional inhibitory receptors in the phagocytic process. |
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35. |
Review of polymorphic screening studies of Japanese, Thai, and Chinese populations indicates that FCGR2B is a susceptibility gene associated with systemic lupus erythematosus. |
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36. |
human malignant melanoma cells express the inhibitory low-affinity Fc(gamma) receptor Fc(gamma)RIIB1 in 40% of tested metastases |
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37. |
the FcgammaRIIB-50T-225C haplotype might be a susceptible factor of SLE in the Chinese population |
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38. |
Susceptibility to type 1 Autoimmune hepatitis in Japanese patients is not influenced by FcgammaRIIA, FcgammaRIIB, or FCRL3 polymorphisms. |
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39. |
Here we demonstrate for the first time FcgammaRIIb protein expression and function in human monocytes |
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40. |
a recently described SLE-associated polymorphism of FcgammaRIIb (FcgammaRIIbT(232)), encoding a single transmembrane amino acid substitution, is functionally impaired |
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41. |
no association between fcgammar2b and systemic lupus erythematosus in Swedish population |
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42. |
Fcgamma receptor IIb polymorphisms are associated with susceptibility to systemic lupus erythematosus in Thais |
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43. |
in human aortic endothelial cells, CRP upregulates monocyte-endothelial adhesion by activation of NF-kappaB through engaging the Fcgamma receptors CD32 and CD64. |
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44. |
analysis of CD32B, which is expressed in B-cell lymphoma, and a panel of its monoclonal antibodies |
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45. |
These results demonstrate that FcgammaRIIb is important in controlling the immune response to malarial parasites. |
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46. |
FCGR2B is a common susceptibility factor to SLE in the Asians |
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47. |
SHIP1 is necessary for FcgammaRIIB to negatively regulate B cell activation |
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48. |
The response to either dimeric IgG or aggregated IgG (aIgG) was assessed and related to differences in the ratio of FcgammaRIIa to FcgammaRIIb2 mRNA in granulocytes |
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49. |
FcgammaRIIb expression and synthesis occur throughout the placental vascular tree but do not extend into the umbilical cord. |
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50. |
CD32-IgG interaction could directly drive capture and activation of flowing neutrophils, or potentiate activation of cells captured by other routes. |
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51. |
Findings provide strong evidence suggesting that a FcgammaRIIB-Gln50Ter loci might be the susceptible factor of SLE in Chinese population. |
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52. |
results imply a novel functional role of CD13 and Fc gamma receptors (CD32 and CD64)as members of a multimeric receptor complex |
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53. |
Ile232Thr substitution affects the localization and function of FcgammaRIIB; this molecular mechanism may link the polymorphism and susceptibility to systemic lupus erythematosus. |
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54. |
Results suggest that FcgammaRIIB may be impaired at a critical checkpoint in systemic lupus erythematosus in the regulation of memory B cells. |
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55. |
activating protein 1 has a role in the transcriptional regulation of the human FCGR2B promoter mediated by the -343 G -> C polymorphism associated with systemic lupus erythematosus |
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56. |
The inhibitory receptor, Fc gamma RIIb2, is expressed on circulating human monocytes. In human primary monocytes Fc gamma RIIb2 expression is increased by IL-4, a Th2 cytokine and decreased by IFN-gamma, a Th1 cytokine. |
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57. |
Although there is no phenotypic difference in Fc gamma RII expression (Fc gamma RIIb predominating on both adult and cord B cells), the inhibitory Fc gamma RIIb is expressed at lower levels on cord cells. |