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1: CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa [ Homo sapiens ]

GeneID: 1499 updated 21-Nov-2009

[Top][Help]Summary

Official Symbol
CTNNB1provided by HGNC
Official Full Name
catenin (cadherin-associated protein), beta 1, 88kDaprovided by HGNC
Primary Source
HGNC:2514
See related
Ensembl:ENSG00000168036; HPRD:00286; MIM:116806
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTNNB; FLJ25606; FLJ37923; DKFZp686D02253; CTNNB1
Summary
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.

[Top][Help]Genomic regions, transcripts, and products

(plus) Go to reference sequence detailsTry our new Sequence Viewer


[Top][Help]Genomic context

chromosome: 3; Location: 3p21See CTNNB1 in MapViewer

[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into Function What's a GeneRIF?

PubMed 1. nuclear beta-catenin staining level might be associated with tumor recurrence in Giant cell tumor of bone.
PubMed 2. APPL proteins exert their stimulatory effects on beta-catenin/TCF-dependent transcription by decreasing the activity of a Reptin-containing repressive complex
PubMed 3. A novel functional link between beta-catenin and Aurora kinase A, underscoring a critical role of these pathways in multiple myeloma disease progression.
PubMed 4. The Pin1 and beta-catenin signalling pathways were activated in salivary adenoid cystic carcinoma.
PubMed 5. Mutations in CTNNB1 protein is associated with Colorectal Carcinoma.
PubMed 6. Beta-catenin co-immunoprecipitated with Hsp27B1 in breast cancer biopsy samples. Beta-catenin was coexpressed in the same tumor areas & in the same tumor cells that expressed Hsp27.
PubMed 7. VEGF leads to a Rac1-mediated generation of ROS, which, in turn, elevates the tyrosine phosphorylation of VE-cadherin and beta-catenin, ultimately regulating adherens junction integrity.
PubMed 8. CCAR1 is a novel component of Wnt/beta-catenin signaling that plays an important role in transcriptional regulation by beta-catenin.
PubMed 9. p53 overexpression, NF-kappaB positivity, and beta-catenin loss were predictive factors of adverse clinical outcomes in appendiceal mucinous adenocarcinomas.
PubMed 10. SALL4 plays a critical role in the pathogenesis of MDS by causing the aberrant activation of the Wnt/beta-catenin pathway.
PubMed 11. The results suggest that PR55 alpha specifically regulates PP2A-mediated beta-catenin dephosphorylation and plays an essential role in Wnt signaling.
PubMed 12. This is the first report demonstrating an association between nuclear beta-catenin accumulation and target gene activation in adamantinomatous craniopharyngiomas
PubMed 13. Molecular interaction be demonstrated between PPARgamma and beta-Catenin both in breast cancer cell lines and tissue samples.
PubMed 14. Overexpression of beta-catenin in leukemia cells indicates that it might be aberrantly activated in acute leukemia, accelerated or blastic phase of CML.
PubMed 15. Chronic moderate hypoxia induces macrophage activation via the Akt and beta-catenin pathways, providing new insight into the pathogenesis of inflammatory diseases.
PubMed 16. the tyrosine phosphorylation of arm12 is a key marker of cadherin dysfunction and the 4G7 antibody may be useful in screening for a beta-catenin phosphorylation ligand or tyrosine kinases.
PubMed 17. Ectopic expression of either Wnt1 or stabilized beta-catenin in vitro induced the transcription factor Snail and suppressed nephrin expression, leading to podocyte dysfunction
PubMed 18. Data suggest that E-cadherin-based cell-cell adhesion limits Wnt signals by promoting the activity of a junction-localized beta-catenin phosphodestruction complex, which may be relevant to tissue morphogenesis and cell fate decisions during development.
PubMed 19. Type-1 Collagen differentially alters beta-catenin accumulation in primary Dupuytren's Disease cord and adjacent palmar fascia cells.
PubMed 20. Down reglation of beta-catenin is associated with rhabdomyosarcoma.
PubMed 21. These data suggest that repression of ZBP1 by blocking beta-catenin binding at the ZBP1 promoter deregulates its associated mRNAs, leading to the phenotypic changes of breast cancers.
PubMed 22. Downregulation of E-cadherin and diffuse membranous beta-catenin expression suggest a dysregulation of the E-cadherin/beta-catenin complex in Merkel cell carcinoma.
PubMed 23. Wnt/beta-catenin signaling pathway may be activated abnormally in some nasopharyngeal carcinoma (NPC) patients. beta-catenin may be a prognostic factor of NPC.
PubMed 24. APC, E-cadherin, beta-catenin and cyclin D1 may play important roles in tumorigenesis of esophageal squamous cell carcinoma(ESCC).
PubMed 25. Both dysplastic and nondysplastic ACF have altered beta-catenin expression and play a role in colon tumorigenesis.
PubMed 26. Collagen type I may influence the expression of E-cadherin and beta-catenin in carcinoma ex-pleomorphic adenoma.
PubMed 27. Results suggest a role of COP9 signalosome (CSN)-mediated deneddylation in the formation of the beta-catenin-degrading supercomplex and the protection of complex-bound adenomatous polyposis coli via CSN-associated USP15.
PubMed 28. Expression of CTNNB1 and its mechanism of delocalization in intestinal-type early gastric cancer based on mucin expression is reported.
PubMed 29. The down-regulation of miR-122a mediated by aberrant APC/beta-catenin signaling is important to the pathogenesis of gastrointestinal cancers.
PubMed 30. DKK1, alone or combined with beta-catenin, is a novel prognostic predictor for hepatocellular carcinoma patients.
PubMed 31. Aberrant activation of hedgehog pathway may play important roles in endometrial cancer through beta-catenin nuclear accumulation.
PubMed 32. The results regarding beta-catenin expression obtained in our study confirm the previous findings that nuclear accumulation of this protein plays a crucial role in the pathogenesis of aggressive fibromatosis.
PubMed 33. Daxx functions as a positive coregulator in modulating the beta-catenin/TCF4-dependent transcriptional potential via TCF4 interaction.
PubMed 34. E-cadherin, beta-catenin, and ZEB1 have roles in malignant progression of cancer [review]
PubMed 35. Overexpression of beta-catenin is responsible for the development of portal hypertension during liver cirrhosis.
PubMed 36. in stage IIA colon cancer, 4 distinct patterns of nuclear beta-catenin expression were identified that are correlated with different cancer-specific & disease-free survival
PubMed 37. Topo IIalpha interacts with beta-catenin/T-cell factor-4 as a novel transcriptional co-activator in colorectal neoplasms.
PubMed 38. Genome-scale chromosomal copy number alteration profiles and mutational statuses of p53 and beta-catenin in 87 hepatocellular carcinoma tumors were clarified.
PubMed 39. PTEN/Akt/beta-catenin signaling pathway has an important role in regulation of normal and malignant mammary stem/progenitor cell populations.
PubMed 40. This study suggests that NKX2-5 modulates the beta-catenin and GATA4 transcriptional activities in developing human cardiac myocytes.
PubMed 41. Beta-catenin mutations in adenomas associated with pigmented nodular adrenocortical disease, further implicating Wnt-beta-catenin signalling in tumorigenesis linked to bilateral adrenal hyperplasias.
PubMed 42. data confirm and extend previous observations that CTNNB1-mutated tumours represent a distinct molecular subgroup of medulloblastomas with favourable outcome
PubMed 43. suppression of beta-catenin signaling by PCDH24 leads to contact inhibition
PubMed 44. Cten is a novel nuclear partner of beta-catenin, and has an oncogenic activity in colon cancers.
PubMed 45. Quercetin inhibits human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway.
PubMed 46. RNA samples from 21 neuroblastoma showed a highly significant FZD1 and/or MDR1 overexpression after treatment, underlining a role for FZD1-mediated Wnt/beta-catenin pathway in clinical chemoresistance.
PubMed 47. TCF and beta-catenin binding plays important roles in HCCR-1 oncogene expression.
PubMed 48. These results demonstrate a mechanism of sphingosine 1-phosphate-induced endothelial barrier enhancement via beta-catenin-linked adherens junction and focal adhesion interaction.
PubMed 49. The presence of nuclear beta-catenin and high content of mmp-9 in the tumor were associated with abnormal accumulation of laminin in the cytoplasm. These changes were characteristic of colorectal cancer with high invasive metastatic potential.
PubMed 50. GnRH regulation of Jun transcription requires a functional interaction between TCF/LEF and beta-catenin.
PubMed 51. Coexpression of HSP60 and nuclear beta-catenin predicts a worse prognosis of metastatic head and neck cancer patients.
PubMed 52. changes in the Akt/beta-catenin pathway play key roles in the regulation of E-cadherin through the transactivation of the Slug gene in uterine carcinosarcomas.
PubMed 53. accumulation of cytoplasm beta-catenin was increased in hepatocellular carcinoma.
PubMed 54. Our results implicate the potential importance of Pitx2 as a beta-catenin downstream modulator in hair growth control.
PubMed 55. Cadherin-11 mRNA and protein levels are regulated by the activity of GSK3beta and a significant degree of this regulation is exerted by the GSK3 target, beta-catenin, at the level of the cadherin-11 3'UTR
PubMed 56. A novel regulatory mechanism whereby turnover of both endogenous and overexpressed H-Ras protein is controlled by beta-TrCP-mediated ubiquitylation, proteasomal degradation and the Wnt/beta-catenin signaling pathway, is reported.
PubMed 57. Data show that Wnt-5a stimulation of breast epithelial cells leads to increased cell-cell adhesion, and that Wnt-5a/casein kinase Ialpha (CKIalpha)-specific phosphorylation of beta-catenin leads to increased complex formation of beta-catenin/E-cadherin.
PubMed 58. These findings suggest that disruption of the peripheral intestinal circadian clock may be intimately involved in beta-catenin induced intestinal epithelial neoplastic transformation in both mouse and man.
PubMed 59. Knockdown by siRNA in human U251 glioma cells inhibited cell proliferation and invasive ability, and induced apoptotic cell death
PubMed 60. In Alzheimer's disease, amyloid-beta toxicity may downregulate the Wnt/beta-catenin pathway.
PubMed 61. Report mutations in exon 3 of the CTNNB1 gene (beta-catenin gene) in cutaneous adnexal tumors.
PubMed 62. Activation of the beta-catenin pathway by Epstein-Barr virus may contribute to the lymphoproliferation characteristic of Epstein-Barr virus-infected B-cells
PubMed 63. Activation of Wnt/beta-catenin signalling pathway induces chemoresistance to IFN-alpha/5-FU therapy.
PubMed 64. By reducing COX-2 expression, caveolin-1 interrupts a feedback amplification loop involving PGE(2)-induced signaling events linked to beta-catenin/Tcf/Lef-dependent transcription of tumor survival genes including cox-2 itself and survivin.
PubMed 65. Tight junction proteins claudin-1, claudin-3, claudin-4, and the adherens junction protein beta-catenin are overexpressed in colorectal carcinoma.
PubMed 66. Zbed3 is a novel Axin-binding protein that is involved in Wnt/beta-catenin signaling modulation.
PubMed 67. process of adipogenesis is affected by a dynamic link between complexes of emerin and lamins A/C at the nuclear envelope and nucleocytoplasmic distribution of beta-catenin, to influence cellular plasticity and differentiation.
PubMed 68. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
PubMed 69. Activation of the canonical Wingless (Wnt) signaling pathway by a stabilizing mutation of beta-catenin targeted exclusively to thymic epithelial cells changes the initial commitment of endodermal epithelia to a thymic cell fate.
PubMed 70. Beta-catenin mediates soft tissue contracture in clubfoot.
PubMed 71. the cadherin-bound pool of beta-catenin, internalized together with E-cadherin, accumulates at the perinuclear endocytic recycling compartment upon AJ dissociation, and can be translocated into the cell nucleus upon Wnt pathway activation
PubMed 72. Data suggest that deregulation of Wnt/ beta-catenin signaling by WTX gene mutation may be a rare event in the pathogenesis of colorectal, gastric, and hepatocellular carcinomas.
PubMed 73. data suggest that Dkk-1 stimulates the release of beta-catenin from cell membrane and facilitates cell migration which accompanies degradation of beta-catenin/E-cadherin
PubMed 74. Core-fucosylated E-cadherin regulated nuclear beta-catenin accumulation in lung cancer cells.
PubMed 75. The reduced immunoexpression of beta-catenin in the membrane may be related to the high degree of cell indifferentiation in cases of oral squamous cell carcinoma with high scores.
PubMed 76. Reduced expression of E-cadherin/catenin complex in hepatocellular carcinomas.
PubMed 77. Hepatocellular cancers that harbor missense mutations in exon-3 of CTNNB1 exhibit, histologically, a more aggressive phenotype.
PubMed 78. the AURKA/GSK-3beta interaction is important in regulating beta-catenin
PubMed 79. novel role of beta-catenin in endoplasmic reticulum (ER) stress-mediated growth inhibition and a new proapoptotic mechanism triggered by beta-catenin on inhibition of PKC isoforms
PubMed 80. significantly reduced rates of lymph-node metastases were observed in beta-catenin-positive T1 and T2 squamous cell carcinomas of the mouth floor
PubMed 81. Mutations in CTNNB1 gene is associated with Wilms tumor.
PubMed 82. Data suggest that integrin alpha3beta1 is a critical coordinator of epithelial-mesenchyme transition signaling pathways involving beta-catenin and pSmad2.
PubMed 83. There was increased expression of E-cadherin and beta-catenin in the eutopic and ectopic endometrium in adenomyosis.
PubMed 84. No mutations were found in the GSK-3beta phosphorylation sites on exon 3 of beta-catenin gene in this group of patients with the MRKH syndrome.
PubMed 85. Data describe alterations of myocardial intercellular and cell-matrix contacts in hypertrophic tissue, and show intracellular translocation of beta-catenin, alpha-actinin and chondroitin sulfate proteoglycan 6 in both an animal model and in LVH patients.
PubMed 86. Ret/ptc1 cross talks with Met at transcriptional and signaling levels and promotes beta-catenin transcriptional activity to drive thyrocyte neoplastic transformation.
PubMed 87. Mutations in CTNNB1, APC, AXIN1, and AXIN2 are not implicated in nuclear accumulation of beta-catenin, and the expression of cyclin D1 is accelerated independently of beta-catenin in ameloblastomas.
PubMed 88. Beta-catenin overexpression in Dupuytren's disease is unrelated to disease recurrence.
PubMed 89. The main role for transgenic beta-catenin during T cell maturation is at the initial stages, and not the terminal stages, of T cell receptor beta-chain selection, when CD4+CD8+ double-positive cells are normally being generated.
PubMed 90. Enforced expression of stabilized beta-catenin transgene by pre-T cell receptor (TCR) signals downstream of the pre-TCR is sufficient to mediate TCR beta-selection including sustained expression of early growth response (Egr) genes in developing T-cells.
PubMed 91. BCL-W may function as a downstream effector of inappropriate WNT/beta-catenin signalling.
PubMed 92. No mutations were detected in adenomatous polyposis coli protein or beta-catenin in pulmonary artery sarcoma.
PubMed 93. Activated Akt seems to characterize well-differentiated invasive squamous laryngeal carcinomas, loss of E-cadherin and activation of beta-catenin correlated with high grade carcinomas.
PubMed 94. These findings suggest that WNT3A can mediate transcriptional changes in melanoma cells in a manner reminiscent of the known role of Wnt/beta-catenin signaling in normal melanocyte development.
PubMed 95. nuclear translocation of beta-catenin was found in 1 of 4 cases of adult Wilms' tumor; none had a beta-catenin gene mutation; nuclear translocation of beta-catenin & mutation of beta-catenin gene were found in 53% & 15.8% of pediatric Wilms' tumors
PubMed 96. There is no predictive value of nuclear beta-catenin in colorectal cancer outcomes.
PubMed 97. alterations in beta-catenin/E-cadherin complex play a critical role in spindle and/or corded (SPICO) cells' features
PubMed 98. levels in colon carcinomas were not statistically different from levels in adjacent normal mucosa and were not correlated with tumor, nodes, and metastases stage
PubMed 99. In hepatocellular carcinoma (HCC), there is a negative correlation between the positive expression of p130Cas and the normal expression of E-cadherin/beta-catenin. p130Cas plays important roles in the invasion, metastasis and prognosis of HCC.
PubMed 100. Consequences of modulation of PAR1 and PAR2 expression and function on cytotrophoblast invasion and beta-catenin stabilization, were examined.
PubMed 101. 33 (52%) of 64 mantle cell lymphoma tumors showed nuclear localization of beta-catenin, which significantly correlated with the expression of the phosphorylated/inactive form of GSK3beta
PubMed 102. Dkk3 is a negative regulator of beta-catenin and its downregulation contributes to an activation of the beta-catenin signaling pathway
PubMed 103. Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
PubMed 104. analysis of Wnt/beta-catenin and Myc signaling in liver cancer
PubMed 105. The SCF(beta-TrCP) binding site created by phosphorylation of beta-catenin is highly vulnerable to protein phosphatase 2A (PP2A) and must be protected by the adenomatous polyposis coli (APC) tumor suppressor protein.
PubMed 106. close proximity between cPLA(2)alpha and PPARdelta provides advantage for their efficient functional coupling in the nucleus, where AA produced by cPLA(2)alpha becomes immediately available for PPARdelta binding and subsequent beta-catenin activation.
PubMed 107. the combined pattern of positive KL-6 expression and decreased membranous beta-catenin expression by colorectal carcinoma is a useful biomarker for distinguishing a subgroup of patients with a worse prognosis.
PubMed 108. beta-catenin acts together with Lef-1 to influence DeltaNp63 promoter activity and protein expression
PubMed 109. No mutations are observed in the CTNNB1 gene in any of of sporadic colorectal tumors in this study.
PubMed 110. Snail and Slug promote formation of beta-catenin-T-cell factor (TCF)-4 transcription complexes that bind to the promoter of the TGF-beta3 gene to increase its transcription.
PubMed 111. Slit-2-overexpressing breast cancer cells exhibit tumor suppressor capabilities through the novel mechanism of beta-catenin modulation.
PubMed 112. Nuclear beta-catenin expression provides additional information in predicting patient outcome in advanced colorectal cancer.
PubMed 113. MCC is a nuclear, beta-catenin-interacting protein that can act as a potential tumor suppressor in the serrated colorectal cancer pathway by inhibiting Wnt/beta-catenin signal transduction.
PubMed 114. Increased MMP-2 and -9 and altered beta-catenin may play a role in the pathogenesis of endometriosis.
PubMed 115. CTLA-4 is a direct target of Wnt/beta-catenin signaling and is expressed in human melanoma tumors
PubMed 116. Wnt/beta-catenin signaling mediates the differentiation of osteochondral progenitor cells during fracture repair.
PubMed 117. erbin acts as a negative regulator of beta-catenin/T-cell-factor-dependent gene expression. An erbin mutant with a deletion of the N-terminal leucine-rich repeat allows the PDZ domain of erbin to increase beta-catenin/T-cell-factor-dependent transcription
PubMed 118. FHL2-beta-catenin interaction potentiates beta-catenin nuclear translocation and TCF/LEF transcription, resulting in increased Runx2 and alkaline phosphatase expression, which was inhibited by the Wnt inhibitor DKK1.
PubMed 119. The occurrence as an additional hit of a CTNNB1 somatic mutation is associated with larger or more aggressive adrenocortical tumors.
PubMed 120. CTNNB1 protein mutation/expression in hepatocellualr carcinoma and their significance are reported.
PubMed 121. CTNNB1 mutations are highly common in desmoid tumors.
PubMed 122. The pVHL tumour suppressor and the Wnt tumorigenesis pathway are therefore directly linked through Jade-1.
PubMed 123. Polycystin-1 C-terminal tail co-localizes with and binds to beta-catenin in the nucleus.
PubMed 124. SMRT and NCoR have important roles in the regulation of beta-catenin-TCF4-mediated gene transcription
PubMed 125. Beta-catenin mutations do not contribute to cardiac fibroma pathogenesis.
PubMed 126. We define a novel modification of beta-catenin that regulates its nuclear localization and transcriptional function.
PubMed 127. In focal nodular hyperplasia, increased activation of the beta-catenin pathway was found restricted to enlarged perivenous areas
PubMed 128. Our study proved that beta-catenin protein levels are negatively associated with myeloma cells' sensitivity to Bortezomib.
PubMed 129. Report nuclear targeting of beta-catenin and p120ctn during thrombin-induced endothelial barrier dysfunction.
PubMed 130. rather than being translocated to the nucleus for regulating the target gene transcription, Smad7-stabilized-beta-catenin is shunted to the E-cadherin complex to modulate cell-cell adhesion.
PubMed 131. The Wnt/beta-catenin signaling pathway may have a role in megakaryocytopoiesis in polycythemia vera and essential thrombocythemia.
PubMed 132. shRNAs targeted against beta-catenin could have a gene silencing effect and block the WNT signaling pathway. They could inhibit cell growth, increase apoptosis, and induce cell cycle arrest in human colon cancer cell lines.
PubMed 133. the Wnt/beta-catenin pathway contributes to carcinogenesis and cancer cell survival by driving expression of OPG
PubMed 134. A loss of nuclear beta-catenin is the most consistent feature in prostate cancer rather than absolute levels of expression
PubMed 135. Beta-catenin induced through the Wnt receptor complex was significantly more competent transcriptionally than overexpressed beta-catenin, both in cultured cells and in early Xenopus embryos.
PubMed 136. findings suggest that hepatitis B virus X protein (HBx) negatively regulated proliferation of CCL13-HBx-stable cells via the GSK-3beta/beta-catenin cascade
PubMed 137. These experiments suggest that in breast cancer cells, the expression of ZBP1 and the expression of beta-catenin are coordinately regulated.
PubMed 138. Decreased immunoexpression of beta-catenin and E-cadherin in serous ovarian tumors may be helpful in identifying the cases of higher metastatic potential and infiltration ability.
PubMed 139. SOX2 and beta-catenin act in synergy in the transcription regulation of CCND1 in breast cancer cells
PubMed 140. This study reveals for the first time that alpha-catenin is a key regulator of beta-catenin transcriptional activity and that the status of alpha-catenin expression in tumor tissues might have prognostic value for Src targeted therapy
PubMed 141. study examined the presence of mutations in TP53 at codon 249 (Ser-249, considered as a hallmark of mutagenesis by aflatoxin) and in CTNNB1 in circulating free DNA of patients with hepatocellular carcinoma or chronic liver disease from Alexandria, Egypt
PubMed 142. Aberrant accumulation of beta-catenin is very common in parathyroid tumors, and is caused by stabilizing homozygous mutation in 7.3% of Swedish patients.
PubMed 143. results suggest an established Wnt signaling pathway in most gastric cancers, a close correlation of beta-catenin/TCF4-mediated signaling with tumor dissemination, and the unlikelihood of a direct effect of activated Wnt signaling on CD44 expression
PubMed 144. nuclear beta-catenin immunostaining can serve as a sensitive immunohistochemical marker for the diagnosis of endometrial stromal tumors
PubMed 145. three WT1 subtypes were correlated with WT1, IGF2, and CTNNB1 genetics
PubMed 146. WNT3 and DKK1 regulate distinct internalization pathways of LRP6 to tune the activation of beta catenin signaling.
PubMed 147. HIF-1alpha was found to inactivate the Wnt signaling by binding to hARD1 or beta-catenin, which may contribute to the hypoxia-induced growth arrest of tumor cells.
PubMed 148. Mutations of CTNNB1 were observed in cases of gastric cancer.
PubMed 149. Overexpression of a beta-catenin mutant and depletion of SFRP1 using siRNA synergistically upregulated TCF/LEF transcriptional activity.
PubMed 150. study of correlation between mutations & expression of E-cadherin, beta-catenin, occludin & claudin & complexity of colon carcinoma growth; perturbed expression & distribution of these proteins was found, but could not be linked to complexity of growth
PubMed 151. Overexpression of Myc stimulated sebocyte differentiation, whereas overexpression of beta-catenin stimulated involucrin and cornifin expression.
PubMed 152. Peroxisome proliferator-activated receptor gamma suppresses colonic epithelial cell turnover and colon carcinogenesis through inhibition of the beta-catenin/T cell factor pathway.
PubMed 153. These results indicate that localized decrease of beta-catenin contributes to the spatial pattern of differentiation in hESC colonies.
PubMed 154. There is a functional role for the long cytoplasmic domain of CEACAM1 in regulation of beta-catenin activity.
PubMed 155. Determination of role nuclear pore complex in regulating TCF4/beta cateninin mediated Wnt signaling.
PubMed 156. 14-3-3epsilon and 14-3-3zeta are identified as Cby-binding partners.
PubMed 157. betaenin can be involved in polyphenol mediated down regulation of AKT1.
PubMed 158. removal of N-glycans on E-cadherin resulted in elevated tyrosine phosphorylation level of beta-catenin and reduced beta- and alpha-catenins at adherens junctions
PubMed 159. functional significance of combined dysregulation of PKD1 and E-cadherin in prostate cancer; their effect on cell growth is mediated by beta-catenin.
PubMed 160. study showed that the beta-catenin signal transduction pathway was upregulated by chronic alcohol abuse
PubMed 161. CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes
PubMed 162. We show that a fraction of N-cadherin in a complex with catenins is associated with cholesterol/sphingolipid-rich membrane microdomains in aggressive melanoma cells in vitro and experimental melanomas in vivo.
PubMed 163. Mutations in CTNNB1 are associated with melanoma
PubMed 164. the pathway including S100A7/psoriasin and beta-catenin signaling has a role in tumor progression of squamous cell carcinoma of oral cavity
PubMed 165. GSK-3beta enters the nucleus, forms a complex with beta-catenin and lowers the levels of beta-catenin/TCF-dependent transcription in a mechanism that involves GSK-3beta-Axin binding
PubMed 166. Epigenetic repression of DACT3 leads to aberrant Wnt-beta-catenin signaling in colorectal cancer cells.
PubMed 167. the expression manner of PTEN, beta-catenin, and p53 immunocytochemistry was observed in the normal endometrium (proliferative, secretory, and atrophic, and endometrial glandular and stromal breakdown[beta-catenin]
PubMed 168. Crystal structure of a full-length beta-catenin.
PubMed 169. a frizzled module in cell surface collagen 18 inhibits Wnt/beta-catenin signaling
PubMed 170. Data suggest the Wnt/beta-catenin signaling pathway may be associated with ethanol-induced osteonecrosis.
PubMed 171. Combined increased p53 and reduced membranous beta-catenin protein expression indicated a very poor prognosis in patients with esophageal squamous cell carcinoma.
PubMed 172. These results support a functional role for beta-catenin during proliferation of human islet-derived precursor cells (hIPCs) and suggest that activated beta-catenin signalling may also be important during hIPC derivation from islets.
PubMed 173. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
PubMed 174. PTPRK influences transactivating activity of beta-catenin in non-tumoral and neoplastic cells by regulating the balance between signaling and adhesive beta-catenin, thus providing biochemical basis for the hypothesis of PTPRK as a tumor suppressor gene.
PubMed 175. Endogenous KIT and beta-catenin were found to associate in mast cell leukemia cells, and in vitro kinase assay demonstrated that active KIT phosphorylates tyrosine residues of beta-catenin directly.
PubMed 176. Beta-catenin activation through mutation does not occur in CML.
PubMed 177. beta-catenin signalling is essential in sustaining the cancer stem cell phenotype
PubMed 178. WT1 and WTX mutations occur with similar frequency, that they partially overlap in Wilms tumors, and that mutations in WT1, WTX, and CTNNB1 underlie the genetic basis of about one-third of Wilms tumors
PubMed 179. Correlation between beta-catenin mutations and expression of Wnt-signaling target genes in hepatocellular carcinoma.
PubMed 180. study found that Wnt/beta-catenin pathway is involved in the genesis of pulmonary sclerosing haemangioma (PSH), but mutation of exon 3 of the beta-catenin gene rarely contributes to the activation of the Wnt/beta-catenin pathway in PSH
PubMed 181. Wnt signalling induced the interaction between beta-catenin and TBL1-TBLR1, as well as their binding to Wnt target genes. Importantly, the recruitment of TBL1-TBLR1 and beta-catenin to Wnt target-gene promoters was mutually dependent on each other.
PubMed 182. These data indicate that the differential crosstalk between beta-catenin/Tcf and NF-kappaB pathway in various cancer cells resulted from the differences in the regulation of NF-kappaB-induced lzts2 expression.
PubMed 183. Results describe a specific intracellular pathway involving the activation of PP1cgamma to mediate the effects of confluence-induced beta-catenin dephosphorylation.
PubMed 184. The results indicated that HBx induction in the CCL13-HBx stable cell line downregulated Wnt-3/beta-catenin expression and suppressed cell growth by repressing cell proliferation or triggering cell apoptosis.
PubMed 185. a beta-catenin-RET kinase pathway is a critical contributor to the development and metastasis of thyroid carcinoma
PubMed 186. beta-catenin and/or CDX2 immunolabeling may have diagnostic usefulness in the evaluation of serrated polyps
PubMed 187. Nuclear beta-catenin expression correlating with the grade of IEN in polyps and carcinomas supports its role in colorectal carcinogenesis.
PubMed 188. Vpu leads to the depression of both total and beta-catenin-associated E-cadherin levels through beta-TrCP-dependent stabilization of the transcriptional repressor Snail.
PubMed 189. Suggest beta-catenin deregulation is involved in sporadic hepatoblastoma and also suggests that mismatch repair defects and p53 mutations contribute to this rare liver cancer.
PubMed 190. Deregulated beta-catenin signaling may occur in high-risk neuroblastomas without MYCN amplification resulting in transactivation of MYC and other target genes to induce an aggressive phenotype.
PubMed 191. Wnt/beta-catenin pathyway is activated by epigenetic inactivation of Dkk3, thereby promoting the growth of lung cancer cells
PubMed 192. FGF9 mutant tumors showed normal membranous beta-catenin expression and the absence of mutation in the beta-catenin gene
PubMed 193. data indicate that beta-catenin signaling is an intrinsic molecular pathway restricting HIV replication in PBMCs
PubMed 194. The reciprocal crosstalk between beta-catenin/Tcf pathway and NF-kappaB signaling in hMSCs is mediated through the regulation of lzts2 expression.
PubMed 195. Over-expression of beta-catenin was sufficient to suppress the differentiation and mineralization of DPSCs.
PubMed 196. the importance of beta-catenin in the immortalization process of HPCs, from its dispensable role in their maintenance.
PubMed 197. Data indicate that Sox4 and 17 can act as both antagonists and agonists of beta-catenin/TCF activity, and this mechanism may regulate Wnt signaling responses in many developmental and disease contexts.
PubMed 198. beta-catenin as a component of the intercentrosomal linker and define a new function for beta-catenin as a key regulator of mitotic centrosome separation.
PubMed 199. Observational study of gene-disease association. (HuGE Navigator)
PubMed 200. immunohistochemistry for b-catenin may be a powerful tool for detecting those adenomas with an increased risk for malinancy.
PubMed 201. REVIEW of studies pointing to molecular mechanisms that govern the integration between cell-cell adhesion and gene expression, as reflected in the switches between these two functions of beta-catenin in colon cancer cells
PubMed 202. membranous overexpression of E-cadherin and beta-catenin are associated with the metastatic prostate cancer cells in bone and the high frequency of expression suggests their involvement in the intercellular adhesion of the metastatic cells in bone
PubMed 203. Ajuba promoted GSK-3beta-mediated phosphorylation of beta-catenin by reinforcing the association between beta-catenin and GSK-3beta.
PubMed 204. These data show activation of the Wnt/beta-catenin-signalling pathway in uveal melanoma and suggest that components of this pathway might be useful prognostic markers as well as attractive therapeutic targets to treat this disease.
PubMed 205. These observations assign to the tumor suppressor Fhit an unexpected role in the regulation of beta-catenin-mediated gene transcription.
PubMed 206. HER-2/neu transcriptionally activates Jab1 expression via the AKT/beta-catenin pathway in breast cancer cells.
PubMed 207. These observations unravel the interplay between beta-catenin and Rac1 that is initiated by T-Ag and results in stabilization of beta-catenin and its presence in cell membrane ruffles.
PubMed 208. analysis of Epstein-Barr virus, beta-catenin, and E-cadherin in gastric carcinomas
PubMed 209. Beta-Catenin was co-immunoprecipitated with ERalpha, indicating that these two proteins form a new signaling complex and transcription factor.
PubMed 210. an internally truncated LRP5 receptor is strongly implicated in deregulated activation of the WNT/beta-catenin signaling pathway in hyperparathyroid tumors
PubMed 211. Beta-catenin transgene signaling plays a role in the proliferation of neural progenitor cells in the subventricular zone of adult mouse brain.
PubMed 212. FLT3 activation induces beta-catenin tyrosine phosphorylation and nuclear localization.
PubMed 213. This paper focuses on changes in E-cadherin (CDH1), adenomatous polyposis coli (APC), and beta-catenin (CTNNB1) in 50 tumors of the central nervous system
PubMed 214. CTNNB1 mutation is a later event in Wilms tumourigenesis. CTNNB1 mutations might be associated with rhabdomyogenesis
PubMed 215. Characterization of endogenous CDHE-CTNNB complexes with ELISA represents a dramatic improvement over other assays.
PubMed 216. EpCAM is a Wnt-beta-catenin signaling target gene
PubMed 217. KCC3 down-regulates E-cadherin/beta-catenin complex formation by inhibiting transcription of E-cadherin gene and accelerating proteosome-dependent degradation of beta-catenin protein
PubMed 218. Elevated expression of cell-cycle regulators p16(INK4A), p21(CIP1), and cytoplasmic/nuclear beta-catenin correlated with increased colorectal cancers risk, as did elevated expression of survivin and human telomerase reverse transcriptase.
PubMed 219. Re-expression of E-cadherin in HT29(US) cells restored the ability of caveolin-1 to down-regulate beta-catenin-Tcf/Lef-dependent transcription and survivin expression, as seen in HT29(ATCC) cells.
PubMed 220. Interaction of MUCI with CTNNB modulates cyclin D1 in H. pylori-induced stomach neoplasms.
PubMed 221. E-cadherin and beta-catenin have roles in progression of Epstein-Barr virus-associated gastric carcinoma
PubMed 222. Blockade of Wnt3a stimulation of IP(5) generation blocks beta-catenin accumulation
PubMed 223. Sporadic desmoids are usually associated with somatic mutations in codons 41 or 45 of exon 3 of beta-catenin (CTNNB1).
PubMed 224. MUC1 may affect cancer cell migration by increasing E-cadherin/beta-catenin complex formation and restoring E-cadherin membrane localization
PubMed 225. Data show that E-cadherin/beta-catenin-based adherens junctions are dispensable for tight junction formation and apical lumen biogenesis but not for apical lumen remodeling.
PubMed 226. there are somatic mutations of APC & beta-catenin genes in desmoid-type fibromatosis & abnormalities in Wnt signal pathway; these abnormalities may result in aberrant cell proliferation & apoptosis, which may be important in tumorigenesis & progression
PubMed 227. we explored the implication of three proteins (E-cadherin, a- and b-catenins) that form the cadherin-catenin complex, a receptorial structure strictly involved in tumoral vascular invasion and embolization in this biologic event
PubMed 228. Mutation-specific restriction enzyme digestion was used to detect CTNNB1 mutations in desmoid-type fibromatosis.
PubMed 229. Cytoplasmic beta-catenin is associated with COX-2 overexpression, supporting the role of cytoplasmic beta-catenin in stabilizing PTGS2 (COX-2) mRNA.
PubMed 230. variations in beta-catenin protein levels were dependent on post-transcriptional mechanisms involving the Wnt/beta-catenin pathway only in leukemic cells
PubMed 231. Specification of enteroendocrine but not Paneth cells occurs independently of Wnt signals by conditional deletion of beta-catenin transgene in immature cells expressing the transcription factor, neurogenin 3.
PubMed 232. methylation may play important role in progression and metastasis of small bowel carcinoid tumors
PubMed 233. Beta-catenin may have an important role in the development of malignancy and in the determination of biological features of keratoacanthoma and squamous cell carcinoma of the skin.
PubMed 234. racial factor may not be related to the occurrence of mismatch repair defects and CTNNB1 mutations in our multi-racial patient cohort.
PubMed 235. 3,3'-diindolylmethane -induced cell growth inhibition and apoptosis induction are partly mediated through the regulation of Akt/FOXO3a/GSK-3beta/beta-catenin/AR signaling
PubMed 236. TGF-beta is a modulator of beta-Catenin levels in tumoral fibroblasts and non-tumoral fibroblasts, despite the oncogenic mutations already present in this gene in tumoral fibroblasts of desmoid tumors.
PubMed 237. No evidence of mutations in parathyroid adenomas.
PubMed 238. OxPAPC promoted novel interactions between focal adhesion and adherens junction complexes via paxillin and beta-catenin association, which was critically dependent on Rac and Cdc42 activities.
PubMed 239. Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT and BTRC.
PubMed 240. matrix metalloproteinase-2 and 9 and membrane-type 1 matrix metalloproteinase mRNA expression in endometriosis was higher than in normal endometrium whereas E-cadherin, alpha- and beta-catenin mRNA expression was not suppressed in endometriosis
PubMed 241. All 61 meningothelial meningiomas, 10 of 12 invasive meningiomas, and 3 of 5 anaplastic meningiomas were positive for both ECAD and beta-catenin, while these were both negative in all of the fibrous meningiomas.
PubMed 242. TCF4 expression mediated by beta-catenin/p300 may be important for initial steps during trans-differentiation of endometrial carcinoma cells.
PubMed 243. interaction with the co-activator, p300, underlies the trans-repression of beta-catenin signaling by nuclear receptors and their ligands
PubMed 244. Together, we suggest that quercetin is an excellent inhibitor of beta-catenin/Tcf signaling in SW480 cell lines, and the reduced beta-catenin/Tcf transcriptional activity is due to the decreased nuclear beta-catenin and Tcf-4 proteins.
PubMed 245. results suggest that the Wnt/beta-catenin signaling pathway plays dual functions in head and neck squamous cell carcinoma (HNSCC) development: promoting both cell survival and invasive growth of HNSCC cells.
PubMed 246. Wnt/beta-catenin signaling may contribute to colorectal carcinogenesis by reducing the level of the E2F4 cell cycle repressor via an antisense mechanism
PubMed 247. CTNNB1 was expressed strongly on the cuboidal cell membranes and cytoplasm in both tumor types, but to a lesser extent in the polygonal cells, localizing mainly in the cytoplasm.
PubMed 248. Role of Wnt pathway in medulloblastoma oncogenesis: accumulation of beta-catenin in tumor cells was immunohistochemically proven in 5 cases; 2 cases showed positive immunoreactivity for Wnt-1 and another 2 showed mutation of either CTNNB1 or AXIN1
PubMed 249. Abnormal beta-catenin gene expression with invasiveness of primary hepatocellular carcinoma in China.
PubMed 250. Overexpression of beta-catenin is associated with hepatocellular carcinoma
PubMed 251. Wnt signaling pathway associated with beta-catenin regulation in breast cancer tissue
PubMed 252. CTNNB is ubiquinated at specific lysines by the F-box protein beta-TrCP1.
PubMed 253. ubiquitin-independent degradation of alpha-catenin regulates beta-catenin signaling and maintenance of the differentiated phenotype of articular chondrocytes
PubMed 254. colon cancer cells retain significant amounts of LEF-1 induced nuclear beta-catenin compared to LEF-1 transfected normal epithelial cells; beta-Catenin binds directly to CRM1 & overexpression of CRM1 reduces nuclear beta-catenin-mediated transactivation
PubMed 255. beta-catenin mutation and its nuclear localization are frequent causes of Wnt signaling pathway activation suggesting that beta-catenin activation mutations contribute to tumorigenesis of pilomatricomas
PubMed 256. The beta-catenin, the main system of adherens junction, present in the tight junctions in HepG2 cells.
PubMed 257. Nuclear localization of beta-catenin, an indirect evidence of deregulated Wnt signaling pathway, was observed in 5 (19%) small intestinal adenocarcinomas and 36 (71%) colorectal adenocarcinomas.
PubMed 258. results imply that claudin-1 is involved in the beta-catenin-Tcf/LEF signaling pathway
PubMed 259. analysis of a novel, noncanonical mechanism of modulation of beta-catenin signaling through direct phosphorylation of beta-catenin by PKA, promoting its interaction with CREB-binding protein
PubMed 260. Beta-catenin relieves I-mfa-mediated suppression of LEF-1 in mammalian cells.
PubMed 261. Translocalization of beta-catenin is associated with invasion in gastric cancer
PubMed 262. Nr-CAM is the gene most extensively induced by beta catenin
PubMed 263. In conclusion, prolonged CPB time entails neutrophil-mediated decrease in MVEC beta-catenin expression, and thus may be an important trigger for BBB disruption.
PubMed 264. Overexpression of Pin1 and beta-catenin may be closely related with the development and/or progression of colorectal carcinoma and further supports that Pin1 overexpression might contribute to the upregulation of beta-catenin.
PubMed 265. Data suggest a beta-catenin-dependent, stage-specific role for Notch1 signaling in promoting the progression of primary melanoma.
PubMed 266. aardvark gene product
PubMed 267. beta-catenin might be involved in the Hh signaling pathway via enhancement of the transcriptional activity of GLI
PubMed 268. mutations in the CTNNB1 gene most frequently coexisted with mutations in the PTEN gene (7/9, 77.8%).
PubMed 269. Bilateral Wilms tumours showed loss of the wild type WT1 allele (loss of heterozygosity (LOH)) and a tumour specific mutation in catenin beta1 (CTNNB1).
PubMed 270. nuclear beta-catenin expression significantly related to ulcerative growth of colorectal cancer
PubMed 271. Data show that beta-catenin and poly(ADP-ribose) polymerase are cleaved during rhodostomin-induced apoptosis, indicating that cell detachment is a prerequisite for apoptosis.
PubMed 272. the beta-catenin pathway is activated by histamine
PubMed 273. The expression of beta-catenin, p63 and CD34 in the course of androgenetic alopecia is reported.
PubMed 274. Abnormal E-cadherin and alpha-catenin and beta-catenin in pancreatic carcinoma tissues. Abnormal E-cadherin and alpha-catenin with differentiation, lymph node and liver metastases. Aberrant beta-catenin with lymph node and liver metastases.
PubMed 275. Expression of e-cadherin and beta-catenin in human esophageal squamous cell carcinoma: relationships with prognosis.
PubMed 276. Transendothelial migration is compromised in melanoma cells expressing a dominant-negative form of beta-catenin, thus supporting a regulatory role of beta-catenin signaling in this process.
PubMed 277. These results indicate that the altered expression of beta-catenin, but not cyclin D1, in hepatocellular carcinoma may play an important role in tumor progression by stimulating tumor cell proliferation.
PubMed 278. GSK3beta-dependent protein degradation was switched between Hath1 and beta-catenin by Wnt signaling, leading to the dramatic alteration of cell status between proliferation and differentiation in colon cancer
PubMed 279. negative immunoreactivity of beta-catenin in serous carcinomas and the presence of residual tumor seem to be useful markers in selecting patients likely to have an unfavorable course
PubMed 280. Data show that beta-catenin is overexpressed in Kaposi sarcoma and primary effusion lymphoma, and that this overexpression is regulated by the Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen LANA.
PubMed 281. abnormal immunhistochemical E-cadherin and beta-catenin expression is associated with changes in pit pattern in invasive colorectal neoplasms
PubMed 282. beta-catenin, which participates in the Wnt signaling pathway, might play a more important role in the formation of hepatic adenoma than in that of focal nodular hyperplasia.
PubMed 283. TIS7, a negative regulator of transcriptional activity, represses expression of OPN and beta-catenin/Tcf-4 target genes
PubMed 284. beta-catenin level depends on the way and level of Wnt pathway activation
PubMed 285. Regulation of leukemic cell adhesion, proliferation, and survival by beta-catenin.
PubMed 286. Comparative analysis of nuclear and membrane/cytoplasmic beta-catenin can predict local tumor infiltration.
PubMed 287. Arg(96) mutant has a dominant-negative effect on GSK-3beta-dependent phosphorylation of beta-catenin and targeting of beta-catenin for degradation requires prior priming through phosphorylation of Ser(45)
PubMed 288. These results suggest that the TAK1-NLK MAPK cascade is activated by the noncanonical Wnt-5a/Ca(2+) pathway and antagonizes canonical Wnt/beta-catenin signaling.
PubMed 289. Pulse-labeled beta-catenin replaces the beta-catenin bound to the cell surface prebiotinylated E-cadherin immediately after synthesis or arrives at the plasma membrane in a complex with the E-cadherin precursor.
PubMed 290. The MUC1/beta-catenin interaction occurs in primary tumors, & is dramatically increased in metastatic lesions.
PubMed 291. The interaction and functional cooperation between FHL2, CITED4, and CTNNB were studied.
PubMed 292. crosstalk between the beta-catenin and NF-kappaB signaling pathways is an important regulator of intestinal inflammation
PubMed 293. Tumor sections frmo colorectal cancer patients showed elevated expression levels of AKT1, correlating with enhanced cytoplasmic/nuclear expression of beta-catenin.
PubMed 294. Wnt/beta-catenin signalling pathway is activated in most of gastric cancers, which may play pivotal roles either in gastric cancer formation or in tumour invasion and dissemination
PubMed 295. ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas
PubMed 296. Altered beta-catenin distribution in gastric cancer may result from the imbalance of E-cadherin production and Wnt expression, which confers on gastric cancer cells more aggressive behaviors.
PubMed 297. Beta-catenin may be an important modulator of angiogenesis and myocyte regeneration
PubMed 298. Results showed that inhibition of PI-3 kinase with wortmannin was accompanied by a considerably reduced expression of beta-catenin.
PubMed 299. In esophageal adenocarcinomas, nuclear translocation of beta-catenin was observed regardless of the expression of APC.
PubMed 300. targeted inactivation reveals effects of beta-catenin mutation
PubMed 301. Increased expression of beta-catenin is associated with ovarian epithelial cell transformation and in tumour progression
PubMed 302. The presence of activated beta-catenin and c-myc in the epidermis of chronic wounds may serve as a molecular marker of impaired healing
PubMed 303. Mutation in exon 3 of the beta-catenin gene was found in 2 of the 20 endometrial cancer samples; however, it was not found in the 25 endometrial hyperplasias or the 20 associated hyperplasias.
PubMed 304. beta-catenin is downregulated by H2O2 which negatively modulates the Wnt signal pathway
PubMed 305. CTNNB1 signaling plays a critical role in the development of a significant fraction of prostate cancers.
PubMed 306. CKI epsilon-dependent phosphorylation of Dvl enhances the formation of a complex of Dvl-1 with Frat-1 and this complex leads to the activation of Wnt-3a-induced accumulation of beta-catenin
PubMed 307. beta-catenin phosphorylation/degradation is regulated by CDK2
PubMed 308. Here, we generated a fusion in which XWnt8 was fused to the N-terminus of LRP6 and show it synergizes with both Fz4 and Fz5 to potently transactivate beta-catenin-dependent Wnt signaling
PubMed 309. mutations rare in ulcerative colitis-related colorectal carcinomas
PubMed 310. Alterations in beta-catenin and PTEN genes, as well as MSI, are frequent in low-stage ovarian carcinomas of endometrioid type that have a favorable prognosis.
PubMed 311. results demonstrate a role for beta-catenin in regulating FOXO function that is particularly important under conditions of oxidative stress
PubMed 312. ADAM10 has a role in E-cadherin shedding and epithelial cell-cell adhesion, migration, and beta-catenin translocation
PubMed 313. PKA inhibits the ubiquitination of beta-catenin by phosphorylating beta-catenin, thereby causing beta-catenin to accumulate and the Wnt signaling pathway to be activated.
PubMed 314. Beta catenin induced human melanoma growth requires the downstream target Microphthalmia-associated transcription factor.
PubMed 315. When colon cancer cells with high beta-catenin levels were treated with beta-catenin antisense ODNs, VEGF-A expression was reduced by more than 50%. There is a close link between beta-catenin signaling & VEGF-A expression regulation in colon cancer.
PubMed 316. Beta-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cyclin D1 during tumor cell differentiation
PubMed 317. The aberrant expression of beta-catenin protein was statistically correlated to the lymph node metastasis in esophageal cancer.
PubMed 318. Findings suggest that phospho-beta-catenin accumulation in Alzheimer's disease might result from impaired proteasome function.
PubMed 319. cadherins mediate both the association of PS1 and beta-catenin and the effects of PS1 on the cellular levels of beta-catenin
PubMed 320. Phospho-beta-catenin may have a different involvement in invasive breast carcinomas, according to its subcellular distribution.
PubMed 321. BMP-2 antagonizes Wnt-3a signaling in osteoblast progenitors by promoting an interaction between Smad1 and Dvl-1 that restricts beta-catenin activation
PubMed 322. GR can bind beta-catenin in vitro, suggesting that GC and Wnt signaling pathways are linked directly through their effectors
PubMed 323. Splice forms of crucial genes of the Wnt-pathway, beta-Catenin, LRP5, GSK3beta, Axin-1 and CtBP1 are expressed in human colorectal tissue.
PubMed 324. APC regulates beta-catenin phosphorylation and ubiquitination by distinct domains and by separate molecular mechanisms
PubMed 325. Reduced membranous expression of beta-catenin was associated with metastasis in salivary adenoid cystic carcinoma
PubMed 326. Exposure of colon cancer cells to nitric oxide unraveled a so-far-unidentified mechanism of beta-catenin regulation.
PubMed 327. Wnt/beta-catenin signaling has a role in neurodevelopment as well as in neurodegenerative diseases [review]
PubMed 328. Up-regulates prolactin expression using the distal promoter.
PubMed 329. inhibition of beta-catenin and in effect c-myc expression through activation of PPARgamma may help prostate cancer cells to restore several characteristics of normal prostate cells phenotype
PubMed 330. Fascin is a novel target of beta-catenin-TCF signaling and is expressed at the invasive front of human colon cancer
PubMed 331. beta-catenin plays a role in endometrial carcinogenesis, particularly in endometrioid carcinomas
PubMed 332. data support the notion that upregulation of cyclin D1 and Fra-1 in human colorectal adenocarcinomas is driven by abnormally expressed beta-catenin; however, the regulation of c-myc expression in colorectal tumors appears to be more complex
PubMed 333. IpaC interacts with beta-catenin and destabilizes the cadherin-mediated cell adhesion complex.
PubMed 334. alpha-catenin and alpha-catulin have distinct activities that downregulate, respectively, beta-catenin and Ras signals converging on the cyclin D1 promoter
PubMed 335. Activation of AXIN2 expression by beta-catenin-T cell factor
PubMed 336. Restoration of E-cadherin/beta-catenin expression in pancreatic cancer cells inhibits growth by induction of apoptosis.
PubMed 337. types of mutations in sinonasal NK/T cell lymphoma in northeast district of China
PubMed 338. E-cadherin-mediated cell adhesion is required for keratinocyte-mediated control of melanocytic cells, which can override proliferative activity of beta-catenin.
PubMed 339. Induction of the Wnt/beta-catenin pathway by LiCl also elevated PPARgamma levels and induced PPARgamma-dependent reporter and endogenous target genes.
PubMed 340. The regulation of GLCE expression by 2 cis-acting elements of the beta-catenin-TCF4 complex located in the enhancer region of the promoter are reported.
PubMed 341. nuclear beta-catenin is a rare phenomenon in colorectal SRCC, but the involvement of it may indicate a worse prognosis with shorter survival than colorectal SRCC without nuclear beta-catenin expression
PubMed 342. APC and K-ras, but not CTNNB1 mutations have roles in regulation of expression of hMLH1 in sporadic colorectal carcinomas
PubMed 343. sulindac sulfone can modulate the APC/beta-catenin pathway in vitro but its efficacy is dependent upon the mutational status of APC and beta-catenin
PubMed 344. High Pin1 expression in primary prostate cancer markedly inhibits the beta-catenin interaction with androgen receptor.
PubMed 345. active CKIepsilon generation may induce a negative feedback loop by phosphorylation of sites on LRP5/6 that modulate axin binding and hence beta-catenin degradation
PubMed 346. the MED12 interface within Mediator is a new component in the Wnt/beta-catenin pathway
PubMed 347. When beta-catenin is activated in transgenic En1 expressing cells, it induces Dermo1 expression in all cells of the En1 domain and disrupts muscle gene expression.
PubMed 348. histone deacetylase inhibitor sodium butyrate induces G1/S phase arrest in E1A + Ras-transformed cells through down-regulation of E2F1 activity and stabilization of beta-catenin
PubMed 349. Data suggest that intact 654 and 670 tyrosine residues in beta-catenin are crucial in HGF-mediated Met-beta-catenin dissociation, beta-catenin translocation, activation and mitogenesis.
PubMed 350. beta-catenin interferes with transforming growth factor-beta-mediated growth arrest by inducing the expression of BAMBI
PubMed 351. beta-catenin plays an important role in oncogenesis through the crossregulation of NF-kappa B in breast and colonic neoplasms
PubMed 352. provides support that E-cadherin induction by WNT/beta-catenin signaling is an evolutionarily conserved pathway operative in lung cancer cells and that loss of expression may be important in lung cancer development or progression
PubMed 353. High nuclear expression of beta-catenin is correlated with locally advanced colorectal cancer
PubMed 354. beta-catenin/TCF transcriptional activity is blocked by Cdx1 and Cdx2, which then inhibits colon cancer cell proliferation
PubMed 355. beta-catenin is targeted to adhesive or transcriptional complexes, depending on its molecular form
PubMed 356. terminal tail is responsible for discerning among binding of factors to the armadillo domain
PubMed 357. identify selective beta-catenin binding hot spots of Tcf4, E-cadherin, and APC
PubMed 358. Beta-catenin stabilization because of either beta-catenin or AXIN I mutation might be a late event for malignant progression rather than an early genetic event involving the initiation of HCC development.
PubMed 359. Lysophosphatidic acid induced colon cancer cell proliferation requires the beta-catenin signaling pathway.
PubMed 360. The positive inter-regulation between beta-cat/Tcf-4 signaling and ET-1 signaling potentiates proliferation and survival of prostate cancer (CaP) cells, thereby representing a novel mechanism that contributes to CaP progression.
PubMed 361. Immunohistological examination of nuclear accumulation of beta-catenin may be useful for diagnosing malignant immunohistological examination of nuclear accumulation of beta-catenin may thus be useful for diagnosing malignant PLTs.
PubMed 362. CoCoA uses different combinations of functional domains in its synergistic coactivator function with beta-catenin or GRIP1
PubMed 363. beta-catenin, p53 and PCNA may play important roles in the carcinogenesis of colorectal adenoma.
PubMed 364. model of the interactions between beta-catenin and hedgehog signaling in the epidermis in which SHH promotes proliferation of progenitors of the hair lineages whereas IHH stimulates proliferation of sebocyte precursors
PubMed 365. IGF-I modulates androgen signaling through beta-catenin
PubMed 366. LEF-1 expression is regulated through PITX2, LEF-1 and beta-catenin direct physical interactions
PubMed 367. Suppression of beta-catenin expression by small interfering RNA decreased the apoptotic response to TGF-beta.
PubMed 368. a role for beta-catenin in the control of cell cycle and apoptosis at G2/M
PubMed 369. beta-catenin binds to MUC1 and has a role in T cell receptor signaling
PubMed 370. There is a possible role of progesterone in regulation of beta-catenin expression in endometrial tumors. Nuclear beta-catenin accumulation, like gene abnormalities, is associated with the alteration of tumor morphology due to progesterone.
PubMed 371. increased expression predicts favorable prognosis in resected nonsmall cell lung carcinoma
PubMed 372. Loss of expression of E-cadherin and beta-catenin may play an important role in the progression of pulmonary adenocarcinoma.
PubMed 373. found a pattern of beta-catenin immunostaining in typical carcinoid tumors of the appendix that was different from the pattern seen in non-appendiceal carcinoid tumors
PubMed 374. Aberrant beta-catenin expression may play an important role in the histologic differentiation and tumor staging of mucoepidermoid carcinoma.
PubMed 375. Lower levels of nuclear beta-catenin is associated with prostate cancer progression
PubMed 376. beta-catenin accumulates in the nucleus of epithelial cells of juvenile polyps
PubMed 377. beta-catenin is activated by HBxAg, in part, through the upregulated expression of the HBxAg effector URG11; URG11 stimulates the beta-catenin promoter and hepatocellular growth and survival
PubMed 378. These data indicate that the intracellular amounts of HIC1 protein can modulate the level of the transcriptional stimulation of the genes regulated by canonical Wnt/beta-catenin signaling.
PubMed 379. in vivo modulation of PRA1 may be involved in TCF/beta-catenin signaling, as well as cellular proliferation and tumorigenesis
PubMed 380. These findings suggest that the participation of beta-catenin in adhesion and signaling may represent a novel mechanism through which gonadotropins may regulate the cellular fate of human ovarian surface epithelial cells.
PubMed 381. COX-2 and beta-Catenin may have roles in regulating intracellular Survivin levels in mouse and human colon cancer
PubMed 382. Loss of beta-catenin expression is a strong and independent predictor of an unfavorable outcome in patients with endometrial carcinoma.
PubMed 383. hepatocellular carcinomas (HCC) with extensive methylation harbor frequent beta-catenin mutations; HCCs with high levels of chromosomal instability are associated with p53 mutations, suggesting presence of two independent pathways for pathogenesis of HCC
PubMed 384. findings show that WTX, a protein encoded by a gene mutated in Wilms tumors, forms a complex with beta-catenin, AXIN1, beta-TrCP2 and APC; data provide a possible mechanistic explanation for the tumor suppressor activity of WTX
PubMed 385. Transgenic mice express stabilized beta-catenin, which augments IL-7 receptor signaling in thymocytes during positive selection and promotes development of single-positive CD8 antigen-expressing thymocytes.
PubMed 386. dysregulation of beta-catenin may contribute to pancreatic duct adenocarcinoma progression through distinct mechanisms
PubMed 387. FAM associates with E-cadherin and beta-catenin during trafficking to the plasma membrane
PubMed 388. Expression and prognostic roles of beta-catenin in hepatocellular carcinoma: correlation with tumor progression and postoperative survival
PubMed 389. Anticancer-drug-induced apoptotic cell death in leukemia cells is associated with proteolysis of beta-catenin. beta-Catenin plays a role in promoting Jurkat survival.
PubMed 390. Presenilin couples beta-catenin phosphorylation through two sequential kinase activities independent of the Wnt-regulated Axin/CK1alpha complex.
PubMed 391. Immunohistochemistry of cyclin D1 and beta-catenin, and mutational analysis of exon 3 of beta-catenin gene in parathyroid adenomas
PubMed 392. In human pilomatricoma, the frequency of beta-catenin gene mutations was remarkably low (30%),in Exon 3 of the beta-catenin gene .
PubMed 393. Beta-catenin gene mutations are a peculiar feature of skin tumors with matrical differentiation and correlate with a pattern of intense and diffuse beta-catenin nuclear expression.
PubMed 394. beta-catenin plays a central role in mesenchymal cells during the healing process, and is an appealing therapeutic target for disorders of wound healing.
PubMed 395. Gas2DN can increase the activity of calpain and induce degradation of stabilized/mutated beta-catenin
PubMed 396. cyclooxygenase-2/PGE2 may exert pro-oncogenic actions through stimulating the beta-catenin/T cell factor-mediated transcription, which plays critical roles in colorectal carcinogenesis
PubMed 397. Expressed Bcr is able to bind the transcription factor Tcf1 to disrupt the Tcf1/beta-catenin complex. Phosphorylation of Bcr by the tyrosine kinase pp60(src) can lead to dissociation of the transcriptionally inactive Bcr/Tcf1 complex
PubMed 398. PCP-2 may play an important role in the maintenance of epithelial integrity, and a loss of its regulatory function may be an alternative mechanism for activating beta-catenin signaling.
PubMed 399. Results suggest that alternative splicing and AU-rich elements can act together in regulating beta-catenin mRNA stability and thereby provide a step of controlling the cellular beta-catenin concentration.
PubMed 400. beta-catenin is regulated via epsilon-cleavage of N-cadherin
PubMed 401. accumulation of beta-catenin in colorectal cancer is related to chromosomal instability
PubMed 402. N-cadherin and beta-catenin play role in cell migration via PDGF-Rbeta-mediated signaling through the scaffolding molecule NHERF2
PubMed 403. Decreased beta-catenin expression is associated with advanced gallbladder cancers
PubMed 404. No germline mutations of CTNNB1 have been identified nor linkage to chromosome 3p21 been demonstrated in 8 subjects with Birt-Hogg-Dube syndrome, suggesting that CTNNB1 should be excluded as a candidate gene for BHD.
PubMed 405. beta-catenin has a role in progression of colorectal neoplasms
PubMed 406. wnt3a-beta catenin signaling regulates LEF-1 gene expression
PubMed 407. Proof for the regulated phosphorylation of the Ser/Thr residues of beta-catenin by Wnt signaling.
PubMed 408. in breast and lung tumor cells, MDA-7 protein expression modulates cell-cell adhesion and intracellular signaling via coordinate regulation of the beta-catenin and PI3K pathways
PubMed 409. MUC1 and beta-catenin have a role in progression and invasiveness of colorectal carcinomas
PubMed 410. beta-catenin nuclear accumulation plays a role in Dukes' D human colorectal cancers
PubMed 411. there is cross-talk between Wnt and estrogen signaling pathways via functional interaction between beta-catenin and ERalpha
PubMed 412. data indicate that altered expression of beta-catenin may play an important role in oral cancer progression through increased proliferation and invasiveness under epidermal growth factor receptor (EGFR) activation but not mutation or cyclin D1 expression
PubMed 413. oxidative stress induces tyrosine phosphorylation and cellular redistribution of occludin-ZO-1 and E-cadherin-beta-catenin complexes by a tyrosine-kinase-dependent mechanism
PubMed 414. CTNNB1 mutations were found in 2/19 adenomas without APC mutation.
PubMed 415. Data indicate that the rate of nuclear export of adenomatous polyposis coli protein (APC), rather than its nuclear import or steady-state levels, determines the transcriptional activity of beta-catenin.
PubMed 416. The cytoplasmic accumulation of beta-catenin is a common characteristic of oral SCC, but is not closely associated with mutational alterations in the APC, beta-catenin and Axin1 genes.
PubMed 417. The data suggest a novel role for tyrosine phosphorylation of N-cadherin by Src family kinases in the regulation of beta-catenin association during transendothelial migration of melanoma cells.
PubMed 418. Beta-catenin might be related to the occurrence and development of kidney tumor.
PubMed 419. CTNNB strongly increased activity of the eN/Nt5 promoter and this increase depended on the presence of TCF-1; demonstrated a link between Wnt signaling and the regulation of eN and ADA, which control the metabolism of adenosine
PubMed 420. beta-catenin is degraded via a retinoid X receptor-mediated pathway
PubMed 421. Mutations of CTNNB1 may not be a factor in tumorigenesis of cervical cancer
PubMed 422. The minimal necessary components of the androgen receptor and beta-catenin required for binding nuclear accumulation of beta-catenin nuclear import appears to be the DNA/ligand binding regions and the Armadillo repeats of beta-catenin
PubMed 423. beta-Catenin transgenic mice show an in vivo hepatotrophic effect secondary to increased basal hepatocyte proliferation
PubMed 424. our data indicate that inactivation of beta-catenin by a 3p21.3 homozygous deletion might be a crucial event in the development of the mesothelioma NCI-H28 cells.
PubMed 425. LECT2, which encodes a protein with chemotactic properties for human neutrophils, is a direct target gene of Wnt/beta-catenin signaling in the liver.
PubMed 426. p53-mediated reduction in beta-catenin involves enhanced phosphorylation of beta-catenin on key NH(2)-terminal serines.
PubMed 427. results indicate selection for APC genotypes that are likely to retain some activity in downregulating beta-catenin signaling
PubMed 428. Mutations of beta-catenin, as well as overexpression of beta-catenin and the Tcf-4 gene, independently activate the Wnt pathway in HCC, with the target gene most likely to be C-myc.
PubMed 429. We conclude, therefore, that two major components of cell-cell interaction synergistically regulate cell cycle progression in HEK293 cells by regulating p21 expression in a beta-catenin/TCF-dependent manner.
PubMed 430. Cyr61 activated the beta-catenin/TCF4 complex, which promoted the expression of c-myc and the latter induced expression of p53
PubMed 431. The beta-catenin expression in hepatocellular carcinoma cells was heterogeneous among types of hepatitis viral infection
PubMed 432. analysis of conformation of the oncogenic protein beta-catenin containing the phosphorylated motif DpSGXXpS bound to the beta-TrCP protein
PubMed 433. These results indicate that CIP4 is critical for beta-catenin-mediated cell-cell adhesion.
PubMed 434. These results unravel a novel pathway in the control of beta-catenin cellular transport and strongly suggest that SYT-SSX2 contributes to tumor development, in part through beta-catenin signaling
PubMed 435. the cross talk of KLF4 and beta-catenin plays a critical role in homeostasis of the normal intestine as well as in tumorigenesis of colorectal cancers.
PubMed 436. The results indicate that estrogen plus overexpressed ERalpha induce LoVo cell apoptosis might mediate through the increase of hTNF-alpha gene expression, which in turn activate caspase-8, -9 and caspase-3 and lead to the DNA fragmentation and apoptosis.
PubMed 437. the central region of APC is unstructured in the absence of beta-catenin and Axin; beta-catenin may interact with each of the APC 15aa and 20aa repeats independently
PubMed 438. Data show that P68 RNA helicase mediates platelet-derived growth factor-induced epithelial mesenchymal transition by displacing Axin from beta-catenin.
PubMed 439. vascular endothelial growth factor expression is induced through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells
PubMed 440. crystallographic analysis of how beta-catenin, BCL9, BCL9-2 and Tcf4 interact
PubMed 441. Alterations in adenomatous polyposis coli/beta-catenin pathway and cyclin D1 dysregulation may contribute to pathogenesis of pleuropulmonary desmoid tumors and solitary fibrous tumors.
PubMed 442. PS/gamma-secretase-mediated cleavage of LAR controls LAR-beta-catenin interaction, suggesting an essential role for PS/gamma-secretase in the regulation of LAR signaling
PubMed 443. the recruitment of PI3K to the E-cadherin/beta-catenin/p120-catenin complex via beta-catenin at the plasma membrane is required for calcium-induced phospholipase C-gamma1 activation and, ultimately, keratinocyte differentiation
PubMed 444. Loss of beta-catenin may result in the disruption of the function of the cell-cell adhesion complex, which may cause weak cell-cell adhesion and confer invasive properties on a tumor.
PubMed 445. abnormal expression of beta-catenin in gastric carcinoma and survival
PubMed 446. Data show that both UBF1 and UBF2 activate RNA polymerase II-regulated, beta-catenin-responsive promoters.
PubMed 447. Results report a new noncanonical pathway through which Wnt-5a antagonizes the canonical Wnt pathway by promoting the degradation of beta-catenin.
PubMed 448. Splice variants of CTNNB1 ands downstream targets were used as markers for neoplastic progression of esophageal cancer.
PubMed 449. Both cell surface reduction and intranuclear accumulation of beta-catenin were detected in intestinal metaplasia
PubMed 450. STMN2 is required for maintaining the anchorage-independent growth state of beta-catenin/TCF-activated hepatoma cells
PubMed 451. Wnt/beta-catenin activation was observed in 65% of pancreatic adenocarcinomas, independently of beta-catenin gene mutations in most tumors
PubMed 452. In conclusion, the canonical Wnt/beta-catenin pathway enhanced monocyte-endothelial cell adhesion without changing expression levels of adhesion molecules.
PubMed 453. These data indicate that somatic mutations affecting APC and CTNNB1 do not play a major role in the pathogenesis of sporadic ependymomas.
PubMed 454. These data indicate that changes in Wnt expression per se are unlikely to be the cause of the observed dysregulation of beta-catenin expression in DD.
PubMed 455. A functional crosstalk between hepatocyte growth factor receptor (MET) and beta-catenin signaling sustains and increases colorectal carcinoma cell invasive properties.
PubMed 456. These data reveal a potentially important role for transcriptionally active beta-catenin in the regulation of Rad6B gene expression, and link aberrant beta-catenin signaling with transcriptional deregulation of Rad6B and breast cancer development.
PubMed 457. beta-catenin may have a role in progression of colorectal neoplasms to metastatic liver lesions
PubMed 458. Glis2 functions as a negative modulator of beta-catenin/TCF-mediated transcription.
PubMed 459. Nuclear beta-catenin expression was significantly greater in Multiple colorectal adenoma patients' tumours than in sporadic adenomas.
PubMed 460. In HT29 and HCT116 colorectal cancer cells, beta-catenin/TCF transcriptional activity is inhibited by AP-2alpha due to formation of AP-2alpha/APC/beta-catenin complex.
PubMed 461. Protein kinase CK2 dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TRCp and enhances beta-catenin degradation [UBC3B]
PubMed 462. findings indicate that alterations of beta-catenin are frequent in cancer of the uterine cervix and suggest that they may play an important role in the development of these tumors
PubMed 463. One out of 62 melanoma cell lines was found to carry a mutation in exon 3 of the beta-catenin gene indicating that aberration of the Wnt-1/wingless pathway through activation of beta-catenin is a rare event
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[Top][Help]HIV-1 protein interactions

Protein    Interaction
1. Vpu HIV-1 Vpu is a strong competitive inhibitor of beta-TrCP and impairs the degradation of SCF-beta-TrCP substrates such as IKBalpha, ATF4 and beta-catenin PubMed

Go to the HIV-1, Human Protein Interaction Database

[Top][Help]Interactions

Description ..........
  Product Interactant Other Gene Complex Source Pubs          
 
  Catenin beta   NP_004291.1   ACP1      HPRD    PubMed
 
  Catenin beta   NP_004053.1   CDH16      HPRD    PubMed
 
  Catenin beta   NP_004352.2   CDH7      HPRD    PubMed
 
  Catenin beta   NP_057363.2   CDH9      HPRD    PubMed
 
  Catenin beta   NP_001886.1   CSNK2A1      HPRD    PubMed
 
  Catenin beta   NP_015566.1   GRIN1      HPRD    PubMed
 
  Catenin beta   NP_542787.1   NEURL2      HPRD    PubMed
 
  Catenin beta   NP_055530.2   RICS      HPRD    PubMed
 
  Catenin beta   NP_060069.2   VEZT      HPRD    PubMed
 
  NP_001895.1   NP_061324.1   AJAP1      HPRD    PubMed
 
  NP_001895.1   NP_000029.1   APC      HPRD    PubMed
APC interacts with Beta-catenin.
  NP_001895.1   NP_000029.2   APC      BIND    PubMed
Beta-catenin interacts with APC. This interaction was modelled on a demonstrated interaction between human beta-catenin and mouse Apc.
  NP_001895.1   NP_000029.2   APC      BIND    PubMed
 
  NP_001895.1   NP_005874.1   APC2      HPRD    PubMed
 
  NP_001895.1   NP_000035.2   AR      HPRD    PubMed
 
  NP_001895.1   Rho guanine nucleotide exchange factor 4   ARHGEF4      HPRD    PubMed
 
  NP_001895.1   AXIN1   AXIN1      HPRD    PubMed
 
  NP_001895.1   Axin 2   AXIN2      HPRD    PubMed
beta-catenin interacts with the Axin2 promoter.
  NP_001895.1   NC_000017.9   AXIN2      BIND    PubMed
CTNNB1 (beta-catenin) interacts with BCL3.
  NP_001895.1   NP_005169.1   BCL3      BIND    PubMed
Beta-catenin interacts with LGS1.
  NP_001895.1   NP_004317.1   BCL9      BIND    PubMed
 
  NP_001895.1   AAQ88694.1   BOC      HPRD    PubMed
 
  NP_001895.1   NP_378663.1   BTRC      HPRD    PubMed
BTRC (Beta-TrCP1) interacts with CTNNB1 (Beta-catenin).
  NP_001895.1      BTRC      BIND    PubMed
 
  NP_001895.1   Carbonic anhydrase IX   CA9      HPRD    PubMed
 
  NP_001895.1   NP_004337.2   CASP3      HPRD    PubMed
 
  NP_001895.1   Caspase 8   CASP8      HPRD    PubMed
 
  NP_001895.1   CHIBBY   CBY1      HPRD    PubMed
CTNNB1 (beta-catenin) interacts with the CCND1 promoter.
  NP_001895.1   NC_000011.8   CCND1      BIND    PubMed
 
  NP_001895.1   NP_444284.1   CCND1      HPRD    PubMed
CTNNB1 (beta-catenin) interacts with the CD82 (KAI1) promoter.
  NP_001895.1   NC_000011.8   CD82      BIND    PubMed
 
  NP_001895.1   BAA88957.1   CDH1      HPRD    PubMed
Beta-catenin interacts with E-cadherin. This interaction was modelled on a demonstrated interaction between beta-catenin from an unspecified species and human E-cadherin.
  NP_001895.1   NP_004351.1   CDH1      BIND    PubMed
Beta-catenin interacts with E-cadherin. This interaction was modelled on a demonstrated interaction between human beta-catenin and mouse E-cadherin.
  NP_001895.1   NP_004351.1   CDH1      BIND    PubMed
E-cadherin interacts with beta-catenin.
  NP_001895.1   NP_004351.1   CDH1      BIND    PubMed
 
  NP_001895.1   NP_001788.2   CDH11      HPRD    PubMed
 
  NP_001895.1   NP_004924.1   CDH15      HPRD    PubMed
 
  NP_001895.1   NP_001783.2   CDH2      HPRD    PubMed
 
  NP_001895.1   NP_071923.2   CDH24      HPRD    PubMed
 
  NP_001895.1   Cadherin 3   CDH3      HPRD    PubMed
 
  NP_001895.1   NP_001786.1   CDH5      HPRD    PubMed
 
  NP_001895.1   Cadherin 8   CDH8      HPRD    PubMed
 
  NP_001895.1   Cyclin dependent kinase 5   CDK5      HPRD    PubMed
 
  NP_001895.1   NP_058648.2   CDON      HPRD    PubMed
 
  NP_001895.1   C/EBP alpha   CEBPA      HPRD    PubMed
 
  NP_001895.1   IKK alpha   CHUK      HPRD    PubMed
 
  NP_001895.1   Catenin (cadherin-associated protein), alpha 1   CTNNA1      HPRD    PubMed
Beta-catenin interacts with alpha-catenin. This interaction was modelled on a demonstrated interaction between human beta-catenin and mouse alpha-catenin.
  NP_001895.1   NP_001894.1   CTNNA1      BIND    PubMed
 
  NP_001895.1   NP_037398.1   CTNNA3      HPRD    PubMed
 
  NP_001895.1   NP_064633.1   CTNNBIP1      HPRD    PubMed
CTNNB1 (beta-catenin) interacts with the DKK1 promoter.
  NP_001895.1   NC_000010.8   DKK1      BIND    PubMed
 
  NP_001895.1   NP_004078.1   DLG1      HPRD    PubMed
 
  NP_001895.1   NP_004738.2   DLG5      HPRD    PubMed
 
  NP_001895.1   NP_001932.1   DSC3      HPRD    PubMed
 
  NP_001895.1   Dishevelled 1   DVL1      HPRD    PubMed
 
  NP_001895.1   Dishevelled 3   DVL3      HPRD    PubMed
 
  NP_001895.1   NP_005219.1   EGFR      HPRD    PubMed
 
  NP_001895.1   NP_004439.1   ERBB2      HPRD    PubMed
beta-catenin interacts with ER-alpha.
  NP_001895.1   NP_000116.1   ESR1      BIND    PubMed
 
  NP_001895.1   Ezrin   EZR      HPRD    PubMed
CTNNB1 (beta-catenin) interacts with the FAS promoter.
  NP_001895.1   NC_000010.8   FAS      BIND    PubMed
CTNNB1 (beta-catenin) interacts with the FGF20 promoter.
  NP_001895.1   NC_000008.9   FGF20      BIND    PubMed
 
  NP_001895.1   FHL2   FHL2      HPRD    PubMed
beta-catenin interacts with FOXO1. This interaction was modelled on a demonstrated interaction between beta-catenin from an unspecified species and human FOXO1.
  NP_001895.1   NP_002006.2   FOXO1      BIND    PubMed
beta-catenin interacts with FOXO3a.
  NP_001895.1      FOXO3      BIND    PubMed
beta-catenin interacts with FOXO4. This interaction was modelled on a demonstrated interaction between human FOXO4 and beta-catenin from an unspecified species.
  NP_001895.1   NP_005929.1   FOXO4      BIND    PubMed
 
  NP_001895.1   NP_036550.1   FSCN2      HPRD    PubMed
 
  NP_001895.1   Guanine nucleotide binding protein, alpha 13   GNA13      HPRD    PubMed
 
  NP_001895.1   Glutamate receptor, ionotropic kainate 2   GRIK2      HPRD    PubMed
GSK3B (GSK3-Beta) interacts with and phosphorylates CTNNB1 (Beta-catenin).
  NP_001895.1   NP_002084.2   GSK3B      BIND    PubMed
 
  NP_001895.1   Transcription factor 1   HNF1A      HPRD    PubMed
CTNNB1 (beta-catenin) interacts with the IGFBP2 promoter.
  NP_001895.1   NC_000002.9   IGFBP2      BIND    PubMed
 
  NP_001895.1   IKK beta   IKBKB      HPRD    PubMed
 
  NP_001895.1   NP_003861.1   IQGAP1      HPRD    PubMed
 
  NP_001895.1   NP_003861.1   IQGAP1      HPRD    PubMed
CTNNB1 (beta-catenin) interacts with the KLK3 (PSA) promoter.
  NP_001895.1   NC_000019.8   KLK3      BIND    PubMed
 
  NP_001895.1   NP_057353.1   LEF1      HPRD    PubMed
LEF-1 interacts with Beta-catenin. This interaction was modeled on a demonstrated interaction between human LEF-1 and mouse Beta-catenin.
  NP_001895.1   NP_057353.1   LEF1      BIND    PubMed
 
  NP_001895.1   NP_036433.2   MAGI2      HPRD    PubMed
MUC1 interacts with beta-catenin.
  NP_001895.1   NP_877418.1   MUC1      BIND    PubMed
 
  NP_001895.1   P15941   MUC1      HPRD    PubMed
NFKB1 (p50) interacts with CTNNB1 (beta-catenin).
  NP_001895.1   NP_003989.2   NFKB1      BIND    PubMed
 
  NP_001895.1   Nuclear receptor subfamily 5, group A, member 1   NR5A1      HPRD    PubMed
beta-catenin interacts with LRH-1.
  NP_001895.1   AAD03155.1   NR5A2      BIND    PubMed
 
  NP_001895.1   NP_000433.2   PECAM1      HPRD    PubMed
 
  NP_001895.1   NP_852664.1   PIK3R1      HPRD    PubMed
 
  NP_001895.1   NP_006212.1   PIN1      HPRD    PubMed
Polycystin-1 interacts with beta-catenin.
  NP_001895.1   NP_000287.2   PKD1      BIND    PubMed
 
  NP_001895.1   Polycystin 1   PKD1      HPRD    PubMed
 
  NP_001895.1   Plakophilin 2   PKP2      HPRD    PubMed
PS1 interacts with beta-catenin.
  NP_001895.1   NP_000012.1   PSEN1      BIND    PubMed
 
  NP_001895.1   PTPN1   PTPN1      HPRD    PubMed
 
  NP_001895.1   Protein-tyrosine phosphatase pez   PTPN14      HPRD    PubMed
 
  NP_001895.1   Receptor type protein tyrosine phosphatase beta   PTPRB      HPRD    PubMed
 
  NP_001895.1   NP_002831.1   PTPRF      HPRD    PubMed
 
  NP_001895.1   Protein tyrosine phosphatase receptor, typeJ   PTPRJ      HPRD    PubMed
 
  NP_001895.1   NP_002835.2   PTPRK      HPRD    PubMed
 
  NP_001895.1   Protein tyrosine phosphatase, receptor type, U   PTPRU      HPRD    PubMed
 
  NP_001895.1   Protein tyrosine phosphatase, receptor zeta 1   PTPRZ1      HPRD    PubMed
 
  NP_001895.1   PYGO1   PYGO1      HPRD    PubMed
CTNNB1 (beta-catenin) interacts with RUVBL2 (reptin).
  NP_001895.1   NP_006657.1   RUVBL2      BIND    PubMed
CTNNB1 (beta-catenin) interacts with the SGK promoter.
  NP_001895.1   NC_000006.9   SGK1      BIND    PubMed
 
  NP_001895.1   NP_004243.1   SLC9A3R1      HPRD    PubMed
 
  NP_001895.1   NP_005892.1   SMAD2      HPRD    PubMed
 
  NP_001895.1   NP_005893.1   SMAD3      HPRD    PubMed
 
  NP_001895.1   SMAD4   SMAD4      HPRD    PubMed
 
  NP_001895.1   SMARCA4   SMARCA4      HPRD    PubMed
 
  NP_001895.1   NP_055419.1   TAX1BP3      HPRD    PubMed
 
  NP_001895.1   TBL1X   TBL1X      HPRD    PubMed
 
  NP_001895.1   NP_003191.1   TCF3      HPRD    PubMed
 
  NP_001895.1   NP_003190.1   TCF4      HPRD    PubMed
 
  NP_001895.1   NP_003190.1   TCF4      HPRD    PubMed
 
  NP_001895.1   Transcription factor 7-like 1   TCF7L1      HPRD    PubMed
 
  NP_001895.1   NP_110383.1   TCF7L2      HPRD    PubMed
TCF-4 interacts with Beta-catenin.
  NP_001895.1   NP_110383.1   TCF7L2      BIND    PubMed
Beta-catenin interacts with TCF4.
  NP_001895.1   NP_110383.1   TCF7L2      BIND    PubMed
beta-catenin interacts with the pS2 promoter.
  NP_001895.1   NC_000021.7   TFF1      BIND    PubMed
 
  NP_001895.1   NP_004603.1   TGFBR1      HPRD    PubMed
 
  NP_001895.1   NP_004643.2   USP9X      HPRD    PubMed
 
  NP_001895.1   APCL        HPRD    PubMed
 
  NP_001895.1   Catenin alpha        HPRD    PubMed
 
  NP_001895.1   Duplin        HPRD    PubMed
 
  NP_001895.1   FAM        HPRD    PubMed
 
  NP_001895.1   ICAT        HPRD    PubMed
 
  NP_001895.1   LMW-PTP        HPRD    PubMed
 
  NP_001895.1   MAGI-1b        HPRD    PubMed
 
  NP_001895.1   Pontin52        HPRD    PubMed
 
  NP_001895.1   S-SCAM        HPRD    PubMed
 
  NP_001895.1   p35        HPRD    PubMed
CTNNB1 (beta-catenin) interacts with the HTATIP-CD82 promoter complex.
  NP_001895.1           BIND    PubMed
Co-localization
  BioGRID:107880   BioGRID:106568   ACP1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:121012   AJAP1      BioGRID    PubMed
Affinity Capture-Western; Co-crystal Structure; Far Western; Reconstituted Complex
  BioGRID:107880   BioGRID:106821   APC      BioGRID    PubMed
Reconstituted Complex
  BioGRID:107880   BioGRID:115585   APC2      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex; Two-hybrid
  BioGRID:107880   BioGRID:106862   AR      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex; Two-hybrid
  BioGRID:107880   BioGRID:113909   AXIN1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:113910   AXIN2      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:67803   Apc2      BioGRID    PubMed
Two-hybrid
  BioGRID:107880   BioGRID:246396   Ar      BioGRID    PubMed
Reconstituted Complex; Two-hybrid
  BioGRID:107880   BioGRID:249455   Axin1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:198287   Axin1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:124859   BOC      BioGRID    PubMed
Reconstituted Complex; Two-hybrid
  BioGRID:107880   BioGRID:219776   Bcl9l      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:107223   CA9      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:118001   CACYBP      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:107880   BioGRID:117311   CBY1      BioGRID    PubMed
Affinity Capture-Western; Co-crystal Structure
  BioGRID:107880   BioGRID:107434   CDH1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:107443   CDH10      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:107444   CDH11      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:107450   CDH17      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:107451   CDH18      BioGRID    PubMed
Affinity Capture-MS; Affinity Capture-Western
  BioGRID:107880   BioGRID:107435   CDH2      BioGRID    PubMed
Affinity Capture-Western; Co-purification
  BioGRID:107880   BioGRID:107436   CDH3      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:107438   CDH5      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:107439   CDH6      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:107440   CDH7      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:107441   CDH8      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:107442   CDH9      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:107880   BioGRID:114376   CDK5R1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:119165   CDON      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:107479   CEBPA      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:107880   BioGRID:107569   CHUK      BioGRID    PubMed
Phenotypic Enhancement
  BioGRID:107880   BioGRID:107777   CREBBP      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:107880   BioGRID:107876   CTNNA1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:118885   CTNNA3      BioGRID    PubMed
Affinity Capture-MS; Reconstituted Complex
  BioGRID:107880   BioGRID:121313   CTNNBIP1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:107881   CTNND1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:114662   DLG5      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:114660   DLGAP1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:108159   DSC3      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:108188   DVL1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:108189   DVL2      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:108190   DVL3      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:107880   BioGRID:108276   EGFR      BioGRID    PubMed
Affinity Capture-Western; Co-localization; Far Western; Reconstituted Complex
  BioGRID:107880   BioGRID:108376   ERBB2      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:108403   ESR1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:113271   EZR      BioGRID    PubMed
Biochemical Activity
  BioGRID:107880   BioGRID:108532   FER      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex; Two-hybrid
  BioGRID:107880   BioGRID:108565   FHL2      BioGRID    PubMed
Biochemical Activity
  BioGRID:107880   BioGRID:108810   FYN      BioGRID    PubMed
Affinity Capture-Western; Biochemical Activity
  BioGRID:107880   BioGRID:109187   GSK3B      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:107880   BioGRID:109414   HNF4A      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:107880   BioGRID:109767   IKBKB      BioGRID    PubMed
Reconstituted Complex
  BioGRID:107880   BioGRID:114353   IQGAP1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:109931   JUP      BioGRID    PubMed
Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
  BioGRID:107880   BioGRID:114375   KAT2B      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex; Two-hybrid
  BioGRID:107880   BioGRID:119354   LEF1      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:107880   BioGRID:110156   LGALS9      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex; Two-hybrid
  BioGRID:107880   BioGRID:114655   MAGI1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:110391   MET      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:107880   BioGRID:110669   MUC1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:110731   MYO7A      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:119685   NLK      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex; Two-hybrid
  BioGRID:107880   BioGRID:108792   NR5A1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:111151   PCSK1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:111201   PECAM1      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:107880   BioGRID:116459   PHB2      BioGRID    PubMed
Affinity Capture-Western; Biochemical Activity
  BioGRID:107880   BioGRID:123029   PHF17      BioGRID    PubMed
Reconstituted Complex
  BioGRID:107880   BioGRID:111313   PIK3R1      BioGRID    PubMed
Reconstituted Complex
  BioGRID:107880   BioGRID:111317   PIN1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:111642   PSEN1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:111731   PTN      BioGRID    PubMed
Reconstituted Complex
  BioGRID:107880   BioGRID:111736   PTPN1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:111745   PTPN11      BioGRID    PubMed
Biochemical Activity
  BioGRID:107880   BioGRID:111747   PTPN13      BioGRID    PubMed
Affinity Capture-MS; Affinity Capture-Western
  BioGRID:107880   BioGRID:111748   PTPN14      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:107880   BioGRID:111756   PTPRF      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:111759   PTPRJ      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:107880   BioGRID:111760   PTPRK      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:115386   PTPRU      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:111767   PTPRZ1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:119719   RAB8B      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:107880   BioGRID:114166   RUVBL1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:112168   RXRA      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:112391   SKP1      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:107880   BioGRID:114769   SLC9A3R1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:110262   SMAD2      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:110263   SMAD3      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:110264   SMAD4      BioGRID    PubMed
Affinity Capture-Western; Co-localization
  BioGRID:107880   BioGRID:110267   SMAD7      BioGRID    PubMed
Affinity Capture-Western; Two-hybrid
  BioGRID:107880   BioGRID:112481   SMARCA4      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:112770   TBL1X      BioGRID    PubMed
Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
  BioGRID:107880   BioGRID:112787   TCF4      BioGRID    PubMed
Co-crystal Structure
  BioGRID:107880   BioGRID:123642   TCF7L1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:112795   TCF7L2      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:112878   TFAP2A      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:112906   TGFBR2      BioGRID    PubMed
Reconstituted Complex
  BioGRID:107880   BioGRID:112943   TLE1      BioGRID    PubMed
Affinity Capture-Western; Two-hybrid
  BioGRID:107880   BioGRID:218059   Tax1bp3      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:107880   BioGRID:113867   USP9X      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:113257   VCL      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107880   BioGRID:120736   VEZT      BioGRID    PubMed

[Top][Help]General gene information

Markers

Ctnnb1(e-PCR), detects polymorphism
Links: UniSTS:508428
PMC130963P1(e-PCR)
Links: UniSTS:270616
PMC130963P2(e-PCR)
Links: UniSTS:270617
GDB:435507(e-PCR)
Links: UniSTS:157235
RH123357(e-PCR)
Links: UniSTS:135733
PMC15782P1(e-PCR)
Links: UniSTS:271430
PMC15782P2(e-PCR)
Links: UniSTS:271431
PMC123056P1(e-PCR)
Links: UniSTS:270433
G42968(e-PCR)
Links: UniSTS:94848
PMC21165P1(e-PCR)
Links: UniSTS:272017
EST12H1(e-PCR)
Links: UniSTS:263086
SHGC-30856(e-PCR)
Links: UniSTS:78024

Phenotypes

Colorectal cancer
MIM: 116806
Hepatoblastoma
MIM: 116806
Hepatocellular carcinoma
MIM: 114550
Medulloblastoma
MIM: 155255
Ovarian cancer
MIM: 167000
Ovarian carcinoma, endometrioid type
MIM: 116806
Pilomatricoma
MIM: 132600

Genotypes

See CTNNB1 SNP Genotype Report
See CTNNB1 SNP Geneview Report
See CTNNB1 SNP Variation Viewer Report Variation View Link

Homology

Homologs of the CTNNB1 gene The CTNNB1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and C.elegans.


Map Viewer (Mouse, Rat)

Pathways

KEGG pathway: Adherens junction
04520
KEGG pathway: Arrhythmogenic right ventricular cardiomyopathy (ARVC)
05412
KEGG pathway: Basal cell carcinoma
05217
KEGG pathway: Colorectal cancer
05210
KEGG pathway: Endometrial cancer
05213
KEGG pathway: Focal adhesion
04510
KEGG pathway: Leukocyte transendothelial migration
04670
KEGG pathway: Melanogenesis
04916
KEGG pathway: Pathogenic Escherichia coli infection
05130
KEGG pathway: Pathways in cancer
05200
KEGG pathway: Prostate cancer
05215
KEGG pathway: Thyroid cancer
05216
KEGG pathway: Tight junction
04530
KEGG pathway: Wnt signaling pathway
04310
Reactome Event:Apoptosis
REACT_578
Reactome Event:Cell-cell adhesion systems
REACT_19331
Reactome Event:Signaling by Wnt
REACT_11045

Gene Ontology Provided by GOA

Process Evidence
Schwann cell proliferation IEA   
T cell differentiation in the thymus IEA   
Wnt receptor signaling pathway through beta-catenin IC PubMed
androgen receptor signaling pathway NAS PubMed
anterior/posterior axis specification IEA   
apoptosis IEA   
bone resorption IEA   
camera-type eye morphogenesis IEA   
cell fate specification IEA   
cell maturation IEA   
cell-cell adhesion IEA   
cell-matrix adhesion IEA   
cellular protein localization IEA   
dorsal/ventral axis specification IEA   
ectoderm development IEA   
embryonic arm morphogenesis IEA   
embryonic axis specification IEA   
embryonic digit morphogenesis IEA   
embryonic hindlimb morphogenesis IEA   
endodermal cell fate commitment IEA   
epithelial to mesenchymal transition TAS PubMed
forebrain development IEA   
gastrulation with mouth forming second IEA   
glial cell fate determination IEA   
heart development IEA   
hemopoiesis IEA   
liver development IEA   
lung development IEA   
midgut development IEA   
morphogenesis of embryonic epithelium IEA   
myoblast differentiation IEA   
negative regulation of chondrocyte differentiation IEA   
negative regulation of osteoclast differentiation IEA   
negative regulation of transcription from RNA polymerase II promoter IEA   
odontogenesis of dentine-containing tooth IEA   
pancreas development IEA   
patterning of blood vessels IEA   
positive regulation of MAPKKK cascade IEA   
positive regulation of epithelial cell differentiation IEA   
positive regulation of gene-specific transcription from RNA polymerase II promoter IDA PubMed
positive regulation of heparan sulfate proteoglycan biosynthetic process IMP PubMed
positive regulation of osteoblast differentiation IEA   
protein heterooligomerization IEA   
proximal/distal pattern formation IEA   
regulation of cell proliferation IEA   
regulation of centriole-centriole cohesion IDA PubMed
response to cadmium ion IEA   
response to cytokine stimulus IEA   
response to estrogen stimulus IEA   
response to hormone stimulus IEA   
response to organic cyclic substance IEA   
skeletal system development IEA   
synapse organization IEA   
synaptic transmission IEA   
synaptic vesicle transport IEA   
thymus development IEA   

[Top][Help]General protein information

Preferred Names
beta-catenin
Names
beta-catenin
OTTHUMP00000209288

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

Genomic

  1. NG_013302.1 RefSeqGene

    Range
    5000..45997
    Download
    GenBank FASTA Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001098209.1 → NP_001091679.1  beta-catenin

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC104307,DA216720,X87838
    Consensus CDS
    CCDS2694.1
    UniProtKB/TrEMBL
    A8K1L7
    UniProtKB/Swiss-Prot
    P35222
    Conserved Domains (2) summary
    cd00020
    Location:399 – 518
    Blast Score: 191
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin...
    cl02500
    Location:350 – 390
    Blast Score: 110
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin...

  2. NM_001098210.1 → NP_001091680.1  beta-catenin

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC104307,DA216720,Z19054
    Consensus CDS
    CCDS2694.1
    UniProtKB/TrEMBL
    A8K1L7
    UniProtKB/Swiss-Prot
    P35222
    Conserved Domains (2) summary
    cd00020
    Location:399 – 518
    Blast Score: 191
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin...
    cl02500
    Location:350 – 390
    Blast Score: 110
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin...

  3. NM_001904.3 → NP_001895.1  beta-catenin

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AC104307,DA216720,X87838
    Consensus CDS
    CCDS2694.1
    UniProtKB/TrEMBL
    A8K1L7
    UniProtKB/Swiss-Prot
    P35222
    Conserved Domains (2) summary
    cd00020
    Location:399 – 518
    Blast Score: 191
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin...
    cl02500
    Location:350 – 390
    Blast Score: 110
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin...

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000003.11

    Range
    41240941..41281938
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NT_022517.18 

    Range
    41180941..41221938
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

  1. AC_000046.1

    Range
    41179362..41220268
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_921651.1 

    Range
    41179362..41220268
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

  1. AC_000135.1

    Range
    41285983..41326987, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_001838877.2 

    Range
    24940674..24981678, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

  Nucleotide   Protein
  genomic   AC104307.2  (43922..84856)   None
  genomic   AY081165.1   AAL89457.1
  genomic   AY463360.1   AAR18817.1
  genomic   CH471055.1   EAW64625.1
       EAW64626.1
       EAW64627.1
       EAW64628.1
  mRNA   AB062292.1   BAB93475.1
  mRNA   AB451264.1   BAG70078.1
  mRNA   AB451392.1   BAG70206.1
  mRNA   AK095242.1   None
  mRNA   AK289932.1   BAF82621.1
  mRNA   AK294778.1   BAG57905.1
  mRNA   AK296790.1   BAG59368.1
  mRNA   AK299954.1   BAG61781.1
  mRNA   AK314776.1   None
  mRNA   BC058926.1   AAH58926.1
  mRNA   BX648430.1   None
  mRNA   CR596976.1   None
  mRNA   CR604301.1   None
  mRNA   DA216720.1   None
  mRNA   X87838.1   CAA61107.1
  mRNA   Z19054.1   CAA79497.1
  other-genetic   EU446854.1   ABZ92383.1
Protein Accession   Links
P35222.1   GenPept   UniProtKB/Swiss-Prot:P35222

[Top][Help]Additional Links

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.