1: CNR1 cannabinoid receptor 1 (brain) [ Homo sapiens ]

GeneID: 1268 updated 8-Nov-2009

[Top][Help]Summary

Official Symbol
CNR1provided by HGNC
Official Full Name
cannabinoid receptor 1 (brain)provided by HGNC
Primary Source
HGNC:2159
Locus Tag
RP1-23D17.1
See related
Ensembl:ENSG00000118432; HPRD:00259; MIM:114610
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CB1; CNR; CB-R; CB1A; CB1R; CANN6; CB1K5; CNR1
Summary
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq]

[Top][Help]Genomic regions, transcripts, and products

(minus strand) Go to reference sequence detailsTry our new Sequence Viewer


[Top][Help]Genomic context

chromosome: 6; Location: 6q14-q15See CNR1 in MapViewer

[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into Function What's a GeneRIF?

PubMed 1. Case-control analysis identified a nominal association between single nucleotide polymorphism of CNR1 and having one or more cannabis dependence symptoms
PubMed 2. Very low or absent FAAH and high CB1 levels correspond with spontaneous miscarriage.
PubMed 3. Our results demonstrated a significant haplotypic effect of CNR1 on migraine headaches.
PubMed 4. The loss of CB(1) receptors in HD is also thought to be a compensatory mechanism due to evidence that endocannabinoids modulate the reuptake of GABA in the GP.
PubMed 5. A role for the cannabinoid receptor 1 gene in cannabis dependence.
PubMed 6. results demonstrate the expression and regulation of CB1 and CB2 receptors and fatty acid amide hydrolase in retinal pigment epithelial cells
PubMed 7. The results represent the first evidence in humans that the CNR1 gene is a risk factor for depression through a high neuroticism and low agreeableness phenotype.
PubMed 8. results suggest that spinal endocannabinoids and CB1 receptors on inhibitory dorsal horn interneurons act as mediators of heterosynaptic pain sensitization and play an unexpected role in dorsal horn pain-controlling circuits
PubMed 9. Circular dichroism (CD) spectroscopy revealed that a peptide corresponding to the full-length C-tail of the human CB1 receptor adopts an alpha-helical conformation in negatively charged and zwitterionic detergents.
PubMed 10. Synthetic CB1 peptide backbone dynamics and rotameric freedom are altered by the peptide's phospholipid bilayer environment, which exerts a dynamic influence on the conformation of a transmembrane helix critical to signal transmission by the CB1 receptor.
PubMed 11. CB1 helices 7 and 8 reconstituted into phospholipid bilayers are oriented in a transmembrane and in-plane (i.e., parallel to the phospholipid membrane surface) fashion, respectively.
PubMed 12. We conclude that two independent CNR1 variants have significant interaction effects on risk for cocaine dependence (CD) in European-Americans; they may also have effects on risk for CD in African-Americans.
PubMed 13. CB1R system may play a role in the development of insulin resistance in human skeletal muscle.
PubMed 14. Higher CB(1) receptor expression was associated with lower scores in several eating disorder inventory-2 subscales including perfectionism, impulse regulation and drive for thinness, indicating impaired endocannabinoid signaling in eating disorders.
PubMed 15. a single nucleotide mutation in CNR1 has a role in colorectal cancer outcome
PubMed 16. There is no evidence for an association of common variants in the CNR1 and FAAH genes with measures of adiposity.
PubMed 17. there was a high frequency of G --> A mutation in the CNR1 gene in patients with esophageal cancer.
PubMed 18. Increase in genetic expression serve as a prognostic factor in prostate cancer.
PubMed 19. These results suggest that CB1 receptors acting through the phosphorylation of ERK are involved not only in the extinction of conditioned fear but also in the adaptation to aversive situations in general.
PubMed 20. Overweight patients and those with metabolic syndrom X show an expression pattern supporting a CB1-mediated overactivity of the endocannabinoid system in human visceral adipose tissue.
PubMed 21. A common CNR1 haplotype (H4; prevalence 0.132) is associated with abnormal lipid homeostasis.
PubMed 22. Reduced mRNA expression along with a possible association between polymorphism genotypes of the CNR1 gene and ectopic pregnancy, suggests a possible genetic predisposition to ectopic pregnancy.
PubMed 23. we did not find substantial difference among the three variants human cannabinoid CB(1) receptor according to the binding affinity, functional potency, and efficacy
PubMed 24. fibroblast-like synoviocytes of knees of rheumatoid arthritis and osteoarthritis patients express cannabinoid receptor (CB)1 and CB2
PubMed 25. Patients with coronary artery disease demonstrated the activation of the endocannabinoid system with elevated levels of blood endocannabinoids and increased expression of CB1 receptor in coronary atheroma
PubMed 26. mu-Opioid receptor forms a functional heterodimer with cannabinoid CB1 receptor: electrophysiological and FRET assay analysis.
PubMed 27. Association of CNR1 with ADHD and post-traumatic stress disorder is reported.
PubMed 28. The CNR1 SNP displayed a significant abstinence x genotype interaction on withdrawal, as well as a main effect on overall levels of craving, while the FAAH SNP displayed a significant abstinence x genotype interaction on craving.
PubMed 29. temporal-spatial expression of FAAH, CB1, and CB2 is regulated during early pregnancy and anandamide detrimentally alters trophoblast proliferation
PubMed 30. CNR1 gene polymorphism is associated with central obesity in this Brazilian population of European ancestry
PubMed 31. down-regulation of survivin by CB1 is mediated by a cyclic AMP-dependent protein kinase A signaling pathway
PubMed 32. CNR1 gene is related to alcohol dependence.
PubMed 33. CNR1 gene assosiated with nicotine dependence
PubMed 34. reduced cortical cannabinoid 1 receptor messenger RNA found in schizophrenia.
PubMed 35. This study indicates that the local cellular environment affects the structural determinants of CB(1)R internalization. Additionally, phosphorylation likely regulates the internalization of (full-length) CB(1)Rs.
PubMed 36. Intracellular CB(1) receptors are functional and their spatial segregation is likely to significantly affect receptor function.
PubMed 37. Schizophrenic subjects with prominent lifetime scores for disorganization and negative symptoms (dimension for hebephrenia) are associated with the CNR1 gene and present a type of symptomatology that resembles chronic cannabinoid-induced psychosis
PubMed 38. The upregulation of CB1 in activated T cells enables cellular responses to cannabinoids
PubMed 39. CNR1 variations increase the risk for obesity and modulate body mass index in European population.
PubMed 40. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
PubMed 41. LH-21 is a low affinity inverse agonist for the CB1 receptor.
PubMed 42. impaired CB1 receptor function promotes passive stress-coping behavior, which, at least in part, might relate to alterations in BDNF function.
PubMed 43. cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development
PubMed 44. No associations were identified between CNR1 genetic variants and cognitive impairment in multiple sclerosis
PubMed 45. Genes such as ELTD1 on chromosome 1, in addition to genes on chromosomes 4 (eg, GABRA2) and 6 (eg, CNR1), may be associated with the genetic risk for cannabis use disorders.
PubMed 46. it is the constitutive activity inherent in the cannabinoid CB1 receptor that reduces the capacity of co-expressed mu opioid receptor to function
PubMed 47. CB(1) receptors are present in the gastric epithelium of the mucosa
PubMed 48. AEA is able to decrease differentiating gene expression by increasing DNA methylation in human keratinocytes, through a p38, and to a lesser extent p42/44, mitogen-activated protein kinase-dependent pathway triggered by CB1R.
PubMed 49. CB1 is densely located in glucagon-secreting alpha cells and less so in insulin-secreting beta cells.
PubMed 50. The profound loss of function in the I2.62T-D2.63N double mutant suggests that, although these residues are not obligatory for agonist recognition, they play a synergistic and crucial role in modulating signal transduction.
PubMed 51. Downregulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus.
PubMed 52. There was no evidence of association between schizophrenia and CNR1 (OR=0.97, 95% CI 0.82-1.13) or CHRNA7 (OR=1.07, 95% CI 0.77-1.49) genotypes, or of interactions between tobacco use and CHRNA7, or cannabis use and CNR1or COMT genotypes.
PubMed 53. Analysis of promoter regions regulating basal and Il-4-inducible expression of CB1 in T-lymphocytes is reported.
PubMed 54. CNR1 gene polymorphisms could be a psychopharmacogenetic rather than a vulnerability factor regarding schizophrenia and its treatment
PubMed 55. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
PubMed 56. Observational study of gene-disease association. (HuGE Navigator)
PubMed 57. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
PubMed 58. No significant difference was found between the schizophrenia and control cases in cannabinoid CB1 receptors binding in the superior temporal gyrus.
PubMed 59. In major depression, CB(1) receptor immunopositive glial cells in the grey matter were decreased. Furthermore, our data show that different medications have an impact on the expression of CB(1) receptors in the ACC.
PubMed 60. Impulsivity was significantly associated with the 6-repeat allele of the triplet repeat polymorphism (AATn/A6; p < .0001), as well as four SNPs in or near the CNR1 receptor gene.
PubMed 61. In conclusion, we could not detect a statistically significant association between mutations in the CNR1 gene and the predisposition to develop schizophrenia.
PubMed 62. Cannabinoid type 1 (CB1) receptors and their respective ligands, the endocannabinoids, have a significant role in the modulation of food intake and motivation to consume palatable food. [REVIEW]
PubMed 63. There is no evidence for an association of CNR1 alleles with obesity in German children.
PubMed 64. insulin may play a key role in the obesity-linked dysregulation of the adipose endocannabinoid system at the gene level
PubMed 65. The endocannabinoid system is activated in obese visceral adipose tissue as shown by decreased FAAH, Cb1, and adiponectin expression.
PubMed 66. G1422A polymorphism in the CNR1 gene is associated with increased abdominal adiposity in obese men.
PubMed 67. CB1 cannabinoid receptor Helix 8 Leu contributes to selective signal transduction mechanisms
PubMed 68. no association of human adipose tissue CNR1 mRNA expression with measures of body fat, metabolic parameters, fat cell function, or adiponectin expression.
PubMed 69. CB(1)R and CB(2)R are differentially linked to lipid rafts, specialized microdomains of the plasma membrane--REVIEW
PubMed 70. CB(1)-induced ERK activation was mediated by PI3K(IB) and this effect may have important consequences in the control of cell death/survival decision.
PubMed 71. evidence that CB1 is able to potentiate an orexigenic receptor, OX1R
PubMed 72. both mRNA for CB(1) and the corresponding protein are expressed in human prostate gland at level comparable with the receptor expressed in cerebellum; CB(1) preferentially expressed in prostate epithelia
PubMed 73. delta(9)-THC induces an influx of extracellular calcium in resting T cells in a CB1- CB2- -dependent manner
PubMed 74. upregulation of CB(1) receptors with concomitant increase in the CB(1) receptor-mediated [(35)S]GTPgammaS binding suggests a role for enhanced cannabinoidergic signaling in the prefrontal cortex of depressed suicides
PubMed 75. apoptosis induced by cannabinoid receptor CB1 and CB2 agonists leads to activation of ERK1/2 leading to G1 cell cycle arrest in prostate cancer cells
PubMed 76. Senile plaques in AD patients express CB1 receptors which show increased nitration. G-protein coupling and CB1 receptor protein expression are markedly decreased in AD brains.
PubMed 77. A 5' Cnr1 "TAG" haplotype displays significant allelic frequency differences between substance abusers & controls in European-American, African-American & Japanese samples. Cnr1 genomic variation appears to play roles in human addiction vulnerability.
PubMed 78. Genetic variants at CNR1 are associated with obesity-related phenotypes in men
PubMed 79. results clearly suggest that Ser7.39, but not Ser2.60, plays a crucial role in mediating ligand specific interactions at the CB(1) receptor; modeling studies predict that Ser7.39 in a g-chi1 conformation may induce a helix bend in transmembrane helix 7
PubMed 80. recombinant protein shows high potency with an endogenous capsaicin-like substance
PubMed 81. dendritic cells were also found to express measurable amounts of CB1 and CB2 receptors and of FAAH. Cell maturation did not consistently modify the expression of these proteins
PubMed 82. the presence of two long alleles in the cnr1 gene was associated with a reduced prevalence of depression in parkinson disease
PubMed 83. the cannabinoid receptor CB1 was not identified in first trimester placenta
PubMed 84. CB1 and CB2 immunoreactivity was observed in cutaneous nerve fiber bundles, mast cells, macrophages, epidermal keratinocytes, and the epithelial cells of hair follicles, sebocytes and eccrine sweat glands.
PubMed 85. decreased thermal stability of T210I receptor & increased level of internalization of a T210I receptor-GFP chimera were also observed. Results suggest that T210 plays key role in governing transition between inactive & active CB(1) receptor states.
PubMed 86. analysis of human cannabinoid receptor 1 truncation
PubMed 87. High expression of CB1 receptor was observed in 29 (45%) in hepatocellular carcinoma.
PubMed 88. Identification of a splice variant of the human CB1 receptor.
PubMed 89. Results are the first report of an significant association between CB1 receptor and a subtype of schizophrenia.
PubMed 90. a nigro-striatal lesion is associated with an increase in CB1 receptors in the basal ganglia in humans and nonhuman primates and that this increase could be reversed by chronic l-DOPA therapy.
PubMed 91. Restricting AN and binging/purging AN may be associated with different alleles of the CNR1 gene coding cannabinoid receptor 1.
PubMed 92. CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (PBMC) from various donor types.
PubMed 93. suggested that homozygous genotype CNR1 1359A/A confers vulnerability to alcohol withdrawal delirium.
PubMed 94. CB1 plays a role in inhibiting neovascularization and skin neoplasm development
PubMed 95. No convincing association is found for cannabinoid receptor type 1 (Cnr1) in a systematic genetic association study in a human sample of postmenopausal osteoporosis patients and matched female controls
PubMed 96. In summary, up-regulation of CB1 in T lymphocytes in response to CBs themselves may facilitate or enhance the various immunomodulatory effects related to CBs.
PubMed 97. CB(1) mRNA expression was negatively correlated with visceral fat mass, fasting insulin and circulating 2-arachidonylglycerol.
PubMed 98. CB1 receptor expression throughout the different areas of the developing human brain suggests a specific role of the endocannabinoid system in the events related to human neural development.
PubMed 99. Findings fail to replicate the original report of an association between SNPs adjacent to an alternative CNR1 exon 3 transcription start site and polysubstance abuse.
PubMed 100. A common CNR1 haplotype is associated with developing fewer cannabis dependence symptoms among adolescents who have experimented with cannabis.
PubMed 101. role of intracellular loops of cannabinoid CB1 receptor in functional interaction with Galpha16.
PubMed 102. CB1 receptor mRNA expression was altered in Parkinson's disease and was affected by alterations in dopaminergic systems.
PubMed 103. CB1R is associated with cholesterol- and sphyngolipid-enriched membrane domains (rafts).
PubMed 104. associated with susceptibility to hebephrenic schizophrenia
PubMed 105. High level of cannabinoid receptor 1 is associated with mantle cell lymphoma
PubMed 106. homology model of the CB(1) cannabinoid receptor
PubMed 107. CB(1) receptors are stabilized in a conformation that enables G(q)11 signaling by the WIN55212-2 cannabinoid agonist, thus shifting the G protein specificity of the receptor
PubMed 108. study shows that CB1 receptors are upregulated in the liver of cirrhotic individuals and expressed in liver fibrogenic cells
PubMed 109. results show that the presence of the CB1 polymorphic allele was significantly associated with a lower body mass index
PubMed 110. Human sperm express functional CB(1)-R, the activation of which negatively influences important sperm functions such as motility.
PubMed 111. lipid rafts control CB1R binding and signaling, and CB1R activation underlies the protective effect of methyl-beta-cyclodextrin against apoptosis
PubMed 112. Sequential assignments of TM5 and intra-cellular loop 3 were accomplished. The obtained structure also showed alpha-helix in the TM5 region, but it was interrupted by a disordered region (Gly204_ILe206).
PubMed 113. Antagonists may prove beneficial in the treatment of proliferative liver fibrosis.
PubMed 114. lipid rafts control CB1R, but not CB2R, and endocannabinoid transport in immune and neuronal cells.
PubMed 115. These data suggest that endocannabinoids regulate pathways affecting skeletal muscle oxidation, effects particularly evident in myotubes from obese individuals.
PubMed 116. Tole of cysteine residues in CB1 ligand binding and activation, and demonstrate a method for mapping key determinants in CB1 structure and function
PubMed 117. 4 SNPs in the CNR1 gene are found to be positively associated with striatal response to happy faces (and not to disgust faces) in humans, using fMRI.

[Top][Help]Interactions

Description ..........
  Product Interactant Other Gene Complex Source Pubs          
HIST4H4 (histone H4) interacts with the CNR1 promoter.
  NC_000006.9   NP_778224.1   HIST4H4      BIND    PubMed
An unspecified isoform of PAX3 interacts with the CNR1 promoter.
  NC_000006.9      PAX3      BIND    PubMed
Pax3/FKHR interacts with the CNR1 promoter.
  NC_000006.9   AAC50053.1        BIND    PubMed
 
  NP_057167.1   NP_002059.1   GNA15      HPRD    PubMed
 
  NP_057167.1   NP_002060.3   GNAI1      HPRD    PubMed
 
  NP_057167.1   NP_002061.1   GNAI2      HPRD    PubMed
 
  NP_057167.1   NP_006487.1   GNAI3      HPRD    PubMed
 
  NP_057167.1   Hypocretin receptor 1   HCRTR1      HPRD    PubMed
Affinity Capture-Western
  BioGRID:107668   BioGRID:109032   GNAI1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107668   BioGRID:109033   GNAI2      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107668   BioGRID:109035   GNAI3      BioGRID    PubMed

[Top][Help]General gene information

Markers

RH70837(e-PCR)
Links: UniSTS:57635
RH80958(e-PCR)
Links: UniSTS:84004
NoName(e-PCR)
Links: UniSTS:482606
NoName(e-PCR)
Links: UniSTS:481334
D6S1243E(e-PCR)
Links: UniSTS:151107
WI-19695(e-PCR)
Links: UniSTS:70980
PMC193595P1(e-PCR)
Links: UniSTS:271751
CNR1(e-PCR)
Links: UniSTS:479925
RH79168(e-PCR)
Links: UniSTS:66763
SHGC-35377(e-PCR)
Links: UniSTS:40666
D6S1909(e-PCR)
Links: UniSTS:24798
NoName(e-PCR)
Links: UniSTS:482039

Homology

Homologs of the CNR1 gene The CNR1 gene is conserved in chimpanzee, dog, mouse, rat, chicken, and zebrafish.


Map Viewer (Mouse, Rat)

Pathways

KEGG pathway: Neuroactive ligand-receptor interaction
04080
Reactome Event:Signaling by GPCR
REACT_14797

[Top][Help]General protein information

Preferred Names
cannabinoid receptor 1
Names
cannabinoid receptor 1
OTTHUMP00000016838
OTTHUMP00000016839
central cannabinoid receptor

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

  1. NM_001160226.1NP_001153698.1  cannabinoid receptor 1 isoform a

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 3, 4, 5, and 6 all encode isoform a. This variant was designated CB1B by PubMed ID: 15289816.
    Source sequence(s)
    AL121835,AL136096
    UniProtKB/TrEMBL
    B2R9T4
    UniProtKB/Swiss-Prot
    P21554
    Conserved Domains (1) summary
    cl10458
    Location:139397
    Blast Score: 428
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_001160258.1NP_001153730.1  cannabinoid receptor 1 isoform a

    Description
    Transcript Variant: This variant (4) contains two alternate exons in the 5' UTR, compared to variant 1. Variants 1, 3, 4, 5, and 6 all encode isoform a. This variant was designated CB1C by PubMed ID: 15289816.
    Source sequence(s)
    AL121835,AL136096
    UniProtKB/TrEMBL
    B2R9T4
    UniProtKB/Swiss-Prot
    P21554
    Conserved Domains (1) summary
    cl10458
    Location:139397
    Blast Score: 428
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. NM_001160259.1NP_001153731.1  cannabinoid receptor 1 isoform a

    Description
    Transcript Variant: This variant (5) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 3, 4, 5, and 6 all encode isoform a. This variant was designated CB1D by PubMed ID: 15289816.
    Source sequence(s)
    AL121835,AL136096
    UniProtKB/TrEMBL
    B2R9T4
    UniProtKB/Swiss-Prot
    P21554
    Conserved Domains (1) summary
    cl10458
    Location:139397
    Blast Score: 428
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  4. NM_001160260.1NP_001153732.1  cannabinoid receptor 1 isoform a

    Description
    Transcript Variant: This variant (6) uses a different exon for its 5' UTR, compared to variant 1. Variants 1, 3, 4, 5, and 6 all encode isoform a. This variant was designated CB1E by PubMed ID: 15289816.
    Source sequence(s)
    AL136096
    UniProtKB/TrEMBL
    B2R9T4
    UniProtKB/Swiss-Prot
    P21554
    Conserved Domains (1) summary
    cl10458
    Location:139397
    Blast Score: 428
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  5. NM_016083.4NP_057167.2  cannabinoid receptor 1 isoform a

    Description
    Transcript Variant: This variant (1) represents the predominant transcript variant and it encodes the longer isoform (a). Variant 1 has also been called CB1A by PubMed ID: 15289816. Variants 1, 3, 4, 5, and 6 all encode isoform a.
    Source sequence(s)
    AL121835,BM682178,BX538191,DA128033,DA768458,X54937,X81120
    Consensus CDS
    CCDS5015.1
    UniProtKB/TrEMBL
    B2R9T4
    UniProtKB/Swiss-Prot
    P21554
    Conserved Domains (1) summary
    cl10458
    Location:139397
    Blast Score: 428
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  6. NM_033181.3NP_149421.2  cannabinoid receptor 1 isoform b

    Description
    Transcript Variant: This variant (2) lacks an internal segment near the 5' end of the coding region, compared to variant 1. The resulting protein (isoform b) has a shorter and distinct N-terminus compared to isoform a. PubMed ID: 15620723 referred to this variant and its protein as CB1b.
    Source sequence(s)
    AY766182,BM682178,BX538191,DA239984,DA793373,DA799263,X54937,X81120
    Consensus CDS
    CCDS5016.1
    UniProtKB/Swiss-Prot
    P21554
    Conserved Domains (1) summary
    cl10458
    Location:106364
    Blast Score: 421
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000006.11

    Range
    88849582..88855055, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)
  2. NT_007299.13 

    Range
    26969416..26974889, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

  1. AC_000049.1

    Range
    89267474..89272947, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)
  2. NW_923184.1 

    Range
    21336078..21341551, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

  1. AC_000138.1

    Range
    86064927..86070400, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)
  2. NW_001838987.1 

    Range
    18243129..18248602, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

  Nucleotide   Protein
  genomic   AL136096.7   CAB96726.1
       CAI19916.1
  genomic   AL136096.7   CAB96726.1
       CAI19916.1
  genomic   AY011601.1   AAG37765.1
  genomic   AY225225.1   AAO67710.1
  genomic   CH471051.2   EAW48574.1
       EAW48575.1
       EAW48576.1
  genomic   U73304.1   AAB18200.1
  mRNA   AF107262.1   AAD34320.1
  mRNA   AK313908.1   BAG36631.1
  mRNA   AY766182.1   AAV35030.1
  mRNA   AY995204.1   AAY21179.1
  mRNA   BC074811.2   AAH74811.1
  mRNA   BC074812.2   AAH74812.1
  mRNA   BC095513.1   AAH95513.1
  mRNA   BC100968.1   AAI00969.1
  mRNA   BC100969.1   AAI00970.1
  mRNA   BC100970.1   AAI00971.1
  mRNA   BC100971.1   AAI00972.1
  mRNA   BM682178.1   None
  mRNA   BX538191.1   None
  mRNA   DA128033.1   None
  mRNA   DA239984.1   None
  mRNA   DA768458.1   None
  mRNA   DA793373.1   None
  mRNA   DA799263.1   None
  mRNA   DQ067455.1   AAY68486.1
  mRNA   X54937.1   CAA38699.1
  mRNA   X81120.1   CAA57018.1
  mRNA   X81121.1   CAA57019.1
Protein Accession   Links
P21554.1   GenPept   UniProtKB/Swiss-Prot:P21554
Q506J9   GenPept   UniProtKB/TrEMBL:Q506J9
Q5JVL5   GenPept   UniProtKB/TrEMBL:Q5JVL5
Q9BYY6   GenPept   UniProtKB/TrEMBL:Q9BYY6

[Top][Help]Additional Links

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.