1: CNN1 calponin 1, basic, smooth muscle [ Homo sapiens ]

GeneID: 1264 updated 8-Nov-2009

[Top][Help]Summary

Official Symbol
CNN1provided by HGNC
Official Full Name
calponin 1, basic, smooth muscleprovided by HGNC
Primary Source
HGNC:2155
See related
Ensembl:ENSG00000130176; HPRD:02884; MIM:600806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMCC; Sm-Calp; CNN1

[Top][Help]Genomic regions, transcripts, and products

(plus) Go to reference sequence detailsTry our new Sequence Viewer


[Top][Help]Genomic context

chromosome: 19; Location: 19p13.2-p13.1See CNN1 in MapViewer

[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into Function What's a GeneRIF?

PubMed 1. Calponin and alpha-inhibin are the most useful positive markers for serous microcystic adenoma, and are negative in most entities in the differential diagnosis.
PubMed 2. expression of vascular CNN1 in the peripheral region of colon cancer tissues was significantly reduced in association with tumor progression, lymphatic invasion, vascular invasion and recurrence.
PubMed 3. the calponin homology domain of Vav1 associates with calmodulin and is prerequisite to T cell antigen receptor-induced calcium release in Jurkat T lymphocytes
PubMed 4. analysis of distinct sites of interaction that form the calponin: gelsolin complex and two calcium switches that control its activity
PubMed 5. results suggest that regulation of h1-calponin is involved in the regulation of differentiation of AR42J cells into insulin-producing cells
PubMed 6. expression in tumor vessels is a new and useful means to predict prognosis of hepatocellular carcinoma after hepatic resection
Submit: New GeneRIF Correction

[Top][Help]Interactions

Description ..........
  Product Interactant Other Gene Complex Source Pubs          
 
  NP_001290.2   Calmodulin 1   CALM1      HPRD    PubMed
 
  NP_001290.2   Protein kinase C epsilon   PRKCE      HPRD    PubMed
 
  NP_001290.2   Tropomyosin 3   TPM3      HPRD    PubMed
 
  NP_001290.2   F actin        HPRD    PubMed
Reconstituted Complex
  BioGRID:107664   BioGRID:106573   ACTA1      BioGRID    PubMed
Reconstituted Complex
  BioGRID:107664   BioGRID:107252   CALM1      BioGRID    PubMed
Reconstituted Complex
  BioGRID:107664   BioGRID:110724   MYO1A      BioGRID    PubMed
Reconstituted Complex
  BioGRID:107664   BioGRID:113021   TPM1      BioGRID    PubMed

[Top][Help]General gene information

Markers

RH78572(e-PCR)
Links: UniSTS:19470
CNN1_8267(e-PCR)
Links: UniSTS:468038
Cnn1(e-PCR), detects polymorphism
Links: UniSTS:516205
STS-N93364(e-PCR)
Links: UniSTS:81124
ksks67(e-PCR)
Links: UniSTS:514533

Homology

Homologs of the CNN1 gene The CNN1 gene is conserved in chimpanzee, dog, cow, mouse, rat, zebrafish, fruit fly, and mosquito.


Map Viewer (Mouse, Rat)

Gene Ontology Provided by GOA

Function Evidence
actin binding IEA   
calmodulin binding IEA   

[Top][Help]General protein information

Preferred Names
calponin 1, basic, smooth muscle
Names
calponin 1, basic, smooth muscle
calponins, basic

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

  1. NM_001299.4 → NP_001290.2  calponin 1, basic, smooth muscle

    Source sequence(s)
    BC022015
    Consensus CDS
    CCDS12263.1
    UniProtKB/TrEMBL
    B2R868
    UniProtKB/Swiss-Prot
    P51911
    Conserved Domains (3) summary
    cd00014
    Location:30 – 127
    Blast Score: 208
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...
    COG5199
    Location:17 – 188
    Blast Score: 222
    SCP1; Calponin [Cytoskeleton]
    pfam00402
    Location:164 – 189
    Blast Score: 119
    Calponin; Calponin family repeat

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000019.9

    Range
    11649578..11661137
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NT_011295.11 

    Range
    2912380..2923939
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

  1. AC_000062.1

    Range
    11544321..11555880
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_927195.1 

    Range
    2760567..2772126
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

  1. AC_000151.1

    Range
    11224160..11235718, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_001838483.2 

    Range
    3039802..3051360, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

  Nucleotide   Protein
  genomic   AC008481.9  (122762..134321)   None
  genomic   CH471106.1   EAW84228.1
       EAW84229.1
  genomic   D85611.1   BAA19538.1
  mRNA   AK223234.1   BAD96954.1
  mRNA   AK300837.1   BAG62488.1
  mRNA   AK301888.1   BAH13577.1
  mRNA   AK313255.1   BAG36065.1
  mRNA   AK316406.1   BAH14777.1
  mRNA   BC022015.2   AAH22015.1
  mRNA   BC036307.1   AAH36307.2
  mRNA   CR615873.1   None
  mRNA   CR620483.1   None
  mRNA   D17408.1   BAA04231.1
  mRNA   D86058.1   BAA12983.1
  mRNA   S80560.1   AAB35751.1
  mRNA   U37019.1   AAC51780.1
Protein Accession   Links
P51911.2   GenPept   UniProtKB/Swiss-Prot:P51911
Q53FP8   GenPept   UniProtKB/TrEMBL:Q53FP8

[Top][Help]Additional Links

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