Official Symbol: CEBPBprovided by HGNC
Official Full Name: CCAAT/enhancer binding protein (C/EBP), betaprovided by HGNC
Primary Source: HGNC:1834
See related: Ensembl:ENSG00000172216; HPRD:01801; MIM:189965
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LAP; CRP2; TCF5; IL6DBP; NF-IL6; MGC32080; C/EBP-beta; CEBPB
Summary: The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene. [provided by RefSeq]

[Top][Help]Genomic regions, transcripts, and products

(plus) Go to reference sequence details Try our new Sequence Viewer

[Top][Help]Genomic context

chromosome: 20; Location: 20q13.1See CEBPB in MapViewer

[Top][Help]Bibliography

GeneRIFs: Gene References Into Function What's a GeneRIF?

	1.	Results demonstrate that intracellular galectin-9 transactivates inflammatory cytokine genes in monocytes through direct physical interaction with NF-IL6.
	2.	data indicate that the PRDM16-C/EBP-beta complex initiates brown fat formation from myoblastic precursors
	3.	Both CBF1 and C/EBP-beta bind the CR2 promoter in B cells raising the possibility that these factors facilitate or respond to alterations in chromatin structure to control the timing and/or level of CR2 transcription.
	4.	Results suggest that the C/EBPalpha and C/EBPbeta transcription factors enhance expression of the TNFR1 protein in cells.
	5.	C/EBPbeta regulated cell growth and conferred TNF-alpha resistance to prostate cancer cells, in part, via regulation of metastatic gene expression
	6.	C/EBPB is up-regulated in multiple myeloma; it directly influences expression of IRF4, BLIMP1, and BCL2
	7.	C/EBPbeta is a mediator of the deleterious effects of unsaturated free fatty acids on beta-cell function.
	8.	C/EBP-beta binds to the CCAAT box in the CD1d promoter, required for its expression in keratinocytes
	9.	ERalpha is involved in the transcriptional regulation of HSD17B8 gene in response to E2 through its interaction with C/EBPbeta.
	10.	Two CCAAT/enhancer-binding protein (C/EBP) family members [C/EBP-homologous protein (CHOP) and C/EBPbeta] enhanced V2 transcription via different pathways.
	11.	C/EBPbeta directly binds to the MMP-13 promoter region and stimulates the expression of MMP-13 in chondrocytes in inflammatory arthritis.
	12.	a composite enhancer binding both PPARgamma and C/EBPa,b factors confers adipocyte-specific expression to Retn in mouse, and its absence from the human gene may explain the lack of adipocyte expression in humans.
	13.	Ha-Ras transformation of MCF10A cells leads to repression of Singleminded-2s through NOTCH and C/EBPbeta.
	14.	C/EBP beta is cyclically regulated during the human menstrual cycle and could have a role in endometrial receptivity.
	15.	C/EBPbeta regulates bcl-xl gene expression in human breast cancer cells in response to cigarette smoke condensate treatment
	16.	P. aeruginosa induces IL-8 promoter expression and protein production in conjunctival epithelial cells by activating RelA and C/EBPbeta and by promoting the cooperative binding of these transcription factors to the IL-8 promoter
	17.	Tumor necrosis factor-alpha upregulates 11beta-hydroxysteroid dehydrogenase type 1 expression by CCAAT/enhancer binding protein-beta in HepG2 cells.
	18.	the interplay between NF-kappaB and C/EBPbeta has an impact on the ability of C/EBPbeta to stimulate TGF-beta1 transcription
	19.	Regulates cytokine production in mature neutrophils; nuclear C/EBPbeta is rapidly phosphorylated upon cell stimulation, suggesting that it can activate cytokine promoters.
	20.	C/EBPbeta was found to have an important role in epithelial cell ICAM-1 regulation, while the adjacent NF-kappaB sequence binds the RelA/p65 and NF-kappaB1/p50 members of the NF-kappaB family to induce ICAM-1 expression in response to H. influenzae.
	21.	NRAMP1 proximal region binds CCAAT enhancer binding proteins alpha or beta and is crucial for transcription
	22.	/EBPbeta as a direct substrate of G9a-mediated post-translational modification that alters the functional properties of C/EBPbeta during gene regulation.
	23.	These data indicate that NF-IL6 is a natural inhibitor of APOBEC3G that facilitates HIV-1 replication.
	24.	Observational study of gene-disease association. (HuGE Navigator)
	25.	Quantitative reverse transcription-polymerase chain reaction (RT-PCR) showed decreased expression of HNF3 beta/FoxA2 and TTF-1 mRNA in papillary thyroid carcinoma cell lines, when compared with normal thyroid cells
	26.	C/EBP beta overexpression significantly upregulated promoter activities of IL-8, COX-2, and anti-apoptotic Bfl-1 genes in prostate cancer cells.
	27.	ERK-regulated site in Med1 protein is also essential for up-regulating interferon-induced transcription although not critical for binding to C/EBP-beta
	28.	Lysophosphatidic acid-induced transactivation of epidermal growth factor receptor regulates cyclo-oxygenase-2 expression and prostaglandin E(2) release via C/EBPbeta in human bronchial epithelial cells.
	29.	C/EBPbeta, which binds to multiple cis-regulatory elements in promoter I.3/II, is a key factor in the transcriptional complex controlling aromatase expression in uterine leiomyoma cells.
	30.	Pyk2 is induced and involved in monocyte differentiation and C/EBPbeta is a critical regulator of the Pyk2 expression.
	31.	The effect of cell density and inflammatory conditions on the expression, compartmentalization, activation, and the anti-proliferative function of the GR in primary human lung fibroblast cultures, was studied.
	32.	PPARgamma agonists have diverging and overlapping mechanisms blocking transactivation of transcription factors NF-kappaB and C/EBPbeta.
	33.	C/EBPbeta was identified as the transcription factor regulating Tas1r3 promoter activity in HuCCT1 cells.
	34.	IL-17 induces MMP-1 in human cardiac fibroblasts directly via p38 MAPK- and ERK-dependent AP-1, NF-kappaB, and C/EBP-beta activation.
	35.	Results identify in Italians a suggestive linkage of early-onset type 2 diabetes (T2D) to chromosome 12q15, in the region of the CHOP gene, but no link to C/EBPbeta.
	36.	CCAAT/enhancer-binding protein beta may play a major role in interleukin-6-mediated inhibition of peroxisome proliferator activated receptor alpha gene expression.
	37.	C/EBP-beta participates in insulin-responsive expression of the F7 gene.
	38.	C/EBPbeta is essential for the transcription of the 17beta-HSD8 gene in the liver
	39.	The evidence is presented indicating that PDX-1 triggers hepatic dedifferentiation by repressing the key hepatic transcription factor CCAAT/enhancer-binding protein beta.
	40.	KGF increased integrin alpha(5) expression by phosphorylating C/EBP-beta
	41.	IL-17 is a potent inducer of CRP expression via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation.
	42.	diacylglycerol acyltransferase 2 expression is regulated by CAAT/enhancer-binding protein beta (C/EBPbeta) and C/EBPalpha during adipogenesis
	43.	Important constitutive gene regulatory functions for C/EBPbeta in differentiated macrophages but not in human blood monocytes.
	44.	There are high levels of FGF-BP expression in invasive human breast cancer, relative to normal breast and in situ carcinoma, and in MDA-MB-468 human breast cancer cells.
	45.	Calcitrio may signal cell differentiation of HL 60 cells which in turn regulates expresson of CEBPB
	46.	Identification of the CEBPB gene as a target of translational regulation in myeloid precursor cells transformed by the BCR/ABL oncogene.
	47.	transcriptional activation of the interleukin-8 promoter by bradykinin involves the prostanoid-independent activation of nuclear factor-kappaB, and prostanoid-dependent activation of activating protein-1 and nuclear factor-interleukin-6
	48.	C/EBP beta is an essential signaling component for inhibition of NF-kappa B-mediated transcription in TNF-tolerant monocytic cells.
	49.	COX-2 is downregulated by PC-SPES via inhibition of NF-kappaB and C/EBPbeta in non-small cell lung cancer cells
	50.	A switch between C/enhancer-binding protein (CEBP) zeta and CEBP beta operates at the CEBP site on the C-reactive protein (CRP)promoter to regulate CRP transcription.
	51.	NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori lipopolysaccharide-stimulated macrophages
	52.	The specific expression pattern of C/EBP-beta in gestational trophoblastic disease indicate that C/EBP-beta could potentially be an additional marker of such lesions.
	53.	Conditional expression of C/EBP alpha induced the C/EBP family members C/EBP beta and C/EBP epsilon and subsequent granulocyte differentiation.
	54.	PGE(2) induces HIV-1 LTR activity in t cells through a complex interplay between C/EBPbeta and CREB
	55.	C/EBPbeta plays an essential constitutive role in the expression of COX-2, but may not be directly involved in its regulation in association with human labour.
	56.	Conserved amino acids regulationregulate phosphoenolpyruvate carboxykinase (PEPCK) gene expression.
	57.	ATRA triggers an increase in the translation of C/EBPbeta-LIP that antagonizes C/EBP transactivators by interacting with their binding sites in the albumin promoter
	58.	5'-region from -252 to -175, containing a consensus site for CCAAT/enhancer binding proteins alpha,beta (C/EBPalpha,beta), was essential for SAA1 induction in HASMCs.
	59.	CCAAT/enhancer-binding protein beta gene expression is activated by endoplasmic reticulum stress through an unfolded protein response element downstream of the protein coding sequence
	60.	IRF-1-CEBPbeta complex activate the promoter of IL-18 binding protein.
	61.	Pretreatment of monocytic cells with low TNF doses inhibited TNF-induced (restimulation with a high dose) IL-8 promoter-dependent transcription as well as IL-8 production, which was prevented by overexpression of C/EBPbeta, but not p65 or Oct-1.
	62.	C/EBPbeta is involved in enhancing transcription from the P670 promoter of HPV16 during keratinocyte differentiation
	63.	identifies new function of C/EBPbeta in LDLR transcription as an oncostatin M-induced transactivator by itself in addition to its role as an EGR-1 co-activator
	64.	Papillomavirus E2 protein binds to C/EBP factors and may contribute to enhancing keratinocyte differentiation, which is suppressed by the viral oncoproteins E6 and E7 in HPV-induced lesions
	65.	Expression levels of C/EBPbeta isoforms in breast tumors were correlated with clinicopathological tumor parameters, expression of estrogen and progesterone receptors (ER, PR), Ki67 immunostaining, and expression of 7 cell-cycle regulatory proteins.
	66.	Ras-induced structural alteration of C/EBPbeta determines differential gene activation through selective interaction with distinct Mediator complexes
	67.	Transactivators C/EPB-beta and GATE-binding factor 1 (GBF1) physically interact to induce interferon-gamma-regulated transcription; an intact GTPS motif in C/EBP beta regulatory domain 2 is required for an interaction with GBF1.
	68.	data demonstrated that chronic inflammation appeared to play roles in induction of CCAAT/enhancer-binding protein beta expression in prostate epithelium which was associated with increased Cyclooxygenase-2 expression and androgen receptor downregulation
	69.	These findings provide new insight into the regulation of cyclooxygenase-2 promoter by an interplay between two opposite beta isoforms and p300 co-activator.
	70.	the level of basal as well as cAMP-stimulated IL-10 transcription depends on the expression of C/EBP alpha and beta and their binding to three motifs in the promoter/enhancer region
	71.	Calreticulin interacts with C/EBPalpha and C/EBPbeta mRNAs and represses translation of C/EBP proteins.
	72.	MEK2 and p38 in IFN-gamma-mediated signal transduction and induction of C/EBP beta expression and activity associated with interleukin-6 (IL-6) secretion in colon epithelial cells.
	73.	EBPbeta could be an important gene in acute promyelocytic leukemia pathogenesis
	74.	Defective thermoregulation owing to the lack of C/EBPbeta is associated with the reduced capacity to supply fatty acids as fuels to sustain brown fat thermogenesis.
	75.	Activation by C/EBP alpha and beta did not depend on their binding to the C/EBP site, since they still activated IGFBP-5 promoter.
	76.	Positively functioning NF-IL6 (C/EBPbeta)is not constitutively multiubiquinated by the proteasome. Deletion of leucine zipper domain in NF-IL6 caused the loss of its homodimerization activity & its degradation by the ubiquitin-proteasome system.
	77.	Regulates HIV-1 transcription in activated Jurkat T cells
	78.	Data show that epidermal growth factor receptor signaling results in phosphorylation of CUG-BP1, and leads to increased binding of CUG-BP1 to CCAAT/enhancer binding protein beta (C/EBP beta) mRNA and elevated expression of the C/EBPbeta LIP isoform.
	79.	GBF1 is recruited to the endogenous IRF-9 promoter, and interacts with C/EBP-beta, IL-1, and IL-6
	80.	Several DNA:transcription factor complexes were formed with the conserved regulatory regions identified in multi-species sequence alignment.
	81.	Decreased activity and enhanced nuclear export of CCAAT-enhancer-binding protein beta during inhibition of adipogenesis by ceramide.
	82.	These results suggest that CSF-induced and HIV-1-mediated regulation of Hck and C/EBPbeta represent the heterogeneous susceptibility of tissue macrophages to HIV-1 infection.
	83.	Overexpression of C/EBP beta was sufficient to increase basal expression of a Dlx3 reporter gene in a dose-dependent manner.
	84.	both phosphorylation and dephosphorylation of C/EBPbeta in response to growth hormone coordinately modulate its ability to activate transcription by modulating its DNA binding activity and its transactivation capacity
	85.	cooperation with cyclic AMP-induced forkhead transcription factor in differentiating human endometrial stromal cells
	86.	findings show that expression of C/EBPbeta, which contributes to the regulation of amino-acid-responsive genes, is itself controlled by amino acid availability through transcription
	87.	Our data suggest that Tat-C/EBPbeta association is mediated through cdk9, and that phosphorylated C/EBPbeta may influence AIDS progression by increasing expression of HIV-1 genes.
	88.	CCAAT/enhancer binding protein-beta is a mediator of PPAR delta-dependent 14-3-3 epsilon gene regulation in human endothelial cells.
	89.	C/EBP beta binding to the C/EBP site, which is in part mediated via activation of RSK, can primarily explain the TPA responsiveness of the IGF-I gene promoter
	90.	Organization of the promoter regions involved in transcriptional activation of the human NF-IL6 gene
	91.	isoform LAP* is the primary isoform of C/EBP beta that regulates, through a redox switch, the LPS-induced expression of the IL-6 gene.
	92.	C/EBP-beta may have a role in promoting tumor invasiveness
	93.	C/EBP beta is identified as a new partner for HIV-1 Tat in stimulating monocyte chemoattractant protein 1 (MCP-1) transcription in astrocytes.
	94.	HMGI-Y physically interacts with Sp1 and C/EBP beta and facilitates the binding of both factors to the insulin receptor promoter
	95.	ATF3-FL and C/EBPbeta act as transcriptional suppressors for the ASNS gene to counterbalance the transcription rate activated by ATF4 following amino acid deprivation
	96.	A new distal enhancer site is identified in the CYP3A4 gene where C/EBPbeta-LAP binds and activates transcription, whereas the truncated form, C/EBPbeta-LIP (liver inhibitory protein), antagonizes LAP activity and causes gene repression.
	97.	C/EBPbeta is involved in the down-regulating of trefoil factor 1 (TFF1) gene expression.
	98.	negative cross-talk between p53 and C/EBPbeta is likely to impact expression of their respective target genes
	99.	Data imply that the comparison of C/EBP beta expression could be a prognostic marker for patients with glioma.
	100.	study provides strong evidence that early growth response 1 regulates low density lipoprotein receptor transcription via a novel mechanism of protein-protein interaction with CCAAT enhancer-binding protein beta
	101.	This factor plays important roles in the regulation of thyroid specific genes and processes, and its functions are altered in human thyroid carcinoma.
	102.	We conclude that C/EBPalpha and C/EBPbeta contribute to the deregulated expression of Bcl-2 in t(14;18) lymphoma cells
	103.	Transfection of NF-IL63'UTR nduced tumor suppression in a human hepatoma cell line.
	104.	demonstrate a novel role for C/EBP-beta in interleukin-1beta-induced connective tissue disease and define a new nuclear target for the Extracellular Signal-Regulated MAP Kinases pathway in matrix metallopeptidase 1 gene activation
	105.	C/EBPbeta plays a key role in the coordination of TGFbeta cytostatic gene responses, and its malfunction may trigger evasion of these responses in breast cancer
	106.	A C/EBP beta element in the FasL promoter, identified by a functionally significant single-nucleotide polymorphism, affects FasL expression in vitro and ex vivo and is associated with systemic lupus erythematosus in African American patients.
	107.	mechanisms of MDR1 activation by C/EBPbeta include C/EBPbeta binding of the chromatin of the MDR1 gene and interactions of C/EBPbeta with the Y box and Y box-associated proteins.
	108.	IL-1 induces CRP expression through 2 overlapping response elements, the binding sites for CCAAT-box/enhancer-binding protein-beta (C/EBP-beta) and p50-nuclear factor-kappaB (p50-NFkappaB).
	109.	Direct interaction between the IL6 promoter and the C/EBP beta protein in myxoid lipoarcoma.
	110.	Together this shows that glucocorticoids increase DNA-binding activity of C/EBPbeta via post-translational mechanism(s) involving phosphorylation.
	111.	constitutive expression of C/EBPbeta in ALK-positive anaplastic large cell lymphoma and its relationship to NPM-ALK
	112.	CCAAT/enhancer binding proteins alpha and beta have roles in growth and differentiation of hepatoblastomas
	113.	c-Rel((1-300)) binding to C/EBPbeta increases the affinity of C/EBPbeta for the C/EBP binding site at -53 on the CRP promoter
	114.	The activities of several functional C/EBPbeta responsive elements in the promoter region and in the intron of CCR5 suggest regulatory roles for C/EBPbeta in CCR5 gene expression and in the pathogenesis of HIV disease.
	115.	CCAAT/enhancer binding protein-beta is a mediator ofkeratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling.

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[Top][Help]HIV-1 protein interactions

Protein	Interaction
1. Tat	Interaction between TGF-beta signaling proteins Smad-3 and Smad-4, and C/EBPbeta modulates basal and HIV-1 Tat-mediated transcription of the HIV-1 LTR promoter in astrocytes	PubMed
2.	Interaction of C/EBPbeta and HIV-1 Tat stimulates MCP-1 transcription in astrocytes	PubMed
3.	HIV-1 Tat induces an increase in C/EBPbeta binding activity through a direct binding interaction between Tat and C/EBPbeta that is mediated through the N-terminal, cysteine rich, and core regions of Tat (amino acids 1-47)	PubMed
4.	HIV-1 Tat upregulates IL-6 expression by transactivating the IL-6 promoter, an effect mediated through enhancement of CAAT enhancer-binding protein (C/EBP; nuclear factor-IL-6) DNA binding activity	PubMed
5.	HIV-1 Tat induces iNOS in human astroglia through the activation of NF-kappaB and C/EBPbeta, an effect that may participate in the pathogenesis of HIV-associated dementia	PubMed
6. Vpr	Upregulation of IL-6, IL-10, TNFalpha, and gamma interferon is linked to HIV-1 Vpr activation of NF-IL-6	PubMed
7.	HIV-1 Vpr activates NF-IL-6 resulting in an increase in IL-8 expression and IL-8 promoter activity and also increases transcription of NF-IL-6 enhancer-containing viral promoters	PubMed

Go to the HIV-1, Human Protein Interaction Database

[Top][Help]Interactions

Description ..........
Product	Interactant	Other Gene	Complex	Source	Pubs

NP_005185.2	Activating transcription factor 2	ATF2		HPRD	PubMed

NP_005185.2	ATF4	ATF4		HPRD	PubMed

NP_005185.2	C/EBP alpha	CEBPA		HPRD	PubMed

NP_005185.2	CCAAT/enhancer binding delta	CEBPD		HPRD	PubMed

NP_005185.2	CCAAT/Enhancer binding protein gamma	CEBPG		HPRD	PubMed

NP_005185.2	Active transcription factor CREB	CREB1		HPRD	PubMed

NP_005185.2	CHOP	DDIT3		HPRD	PubMed

NP_005185.2	CHOP	DDIT3		HPRD	PubMed
DDIT3 (CHOP) interacts with CEBPB (NF-IL6).
NP_005185.2	NP_004074.2	DDIT3		BIND	PubMed

NP_005185.2	EGF receptor	EGFR		HPRD	PubMed

NP_005185.2	NP_001955.1	EGR1		HPRD	PubMed
Egr1 interacts with c/EBP-beta. This interaction was modeled on a demonstrated interaction between mouse Egr1 and human c/EBP-beta.
NP_005185.2	NP_001955.1	EGR1		BIND	PubMed

NP_005185.2	ELK 1	ELK1		HPRD	PubMed

NP_005185.2	E1A binding protein p300	EP300		HPRD	PubMed

NP_005185.2	NP_000116.1	ESR1		HPRD	PubMed

NP_005185.2	NP_002006.2	FOXO1		HPRD	PubMed

NP_005185.2	High mobility group AT hook 1	HMGA1		HPRD	PubMed

NP_005185.2	Heterogeneous nuclear ribonucleoprotein K	HNRNPK		HPRD	PubMed

NP_005185.2	NP_005517.1	HSF1		HPRD	PubMed

NP_005185.2	NP_004821.1	MED23		HPRD	PubMed

NP_005185.2	NP_005366.1	MYB		HPRD	PubMed

NP_005185.2	NP_002458.1	MYC		HPRD	PubMed

NP_005185.2	NFKB1	NFKB1		HPRD	PubMed

NP_005185.2	Nucleolar phosphoprotein p130	NOLC1		HPRD	PubMed

NP_005185.2	Glucocorticoid receptor	NR3C1		HPRD	PubMed
The MBP-P2 promoter interacts with C/EBP-beta.
NP_005185.2	M34462.1	PRG2		BIND	PubMed

NP_005185.2	NP_000312.1	RB1		HPRD	PubMed

NP_005185.2	NFKB3	RELA		HPRD	PubMed

NP_005185.2	CBFA2	RUNX1		HPRD	PubMed

NP_005185.2	Runt related transcription factor 2	RUNX2		HPRD	PubMed

NP_005185.2	SMAD3	SMAD3		HPRD	PubMed

NP_005185.2	NP_005350.1	SMAD4		HPRD	PubMed
CEBPB (C/EBP-beta) interacts with SMAD4. This interaction was modeled on a demonstrated interaction between CEBPB and SMAD4, both from unspecified species.
NP_005185.2	NP_005350.1	SMAD4		BIND	PubMed

NP_005185.2	SMARCA4	SMARCA4		HPRD	PubMed

NP_005185.2	SMARCB1	SMARCB1		HPRD	PubMed

NP_005185.2	NP_003065.2	SMARCC1		HPRD	PubMed

NP_005185.2	Transcription factor Sp1	SP1		HPRD	PubMed

NP_005185.2	SPI1	SPI1		HPRD	PubMed

NP_005185.2	Serum response factor	SRF		HPRD	PubMed

NP_005185.2	STAT5A	STAT5A		HPRD	PubMed

NP_005185.2	STAT6	STAT6		HPRD	PubMed

NP_005185.2	NP_003178.1	TAF9		HPRD	PubMed

NP_005185.2	Transcriptional intermediary factor 1 beta	TRIM28		HPRD	PubMed

NP_005185.2	RNA polymerase II			HPRD	PubMed
Reconstituted Complex
BioGRID:107480	BioGRID:106862	AR		BioGRID	PubMed
Reconstituted Complex
BioGRID:107480	BioGRID:249547	Atf2		BioGRID	PubMed
Affinity Capture-Western
BioGRID:107480	BioGRID:107458	CDK8		BioGRID	PubMed
Reconstituted Complex
BioGRID:107480	BioGRID:107479	CEBPA		BioGRID	PubMed
Reconstituted Complex
BioGRID:107480	BioGRID:107481	CEBPD		BioGRID	PubMed
Reconstituted Complex
BioGRID:107480	BioGRID:107483	CEBPG		BioGRID	PubMed
Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:107775	CREB1		BioGRID	PubMed
Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:108016	DDIT3		BioGRID	PubMed
Affinity Capture-Western
BioGRID:107480	BioGRID:108276	EGFR		BioGRID	PubMed
Reconstituted Complex; Two-hybrid
BioGRID:107480	BioGRID:108278	EGR1		BioGRID	PubMed
Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
BioGRID:107480	BioGRID:108347	EP300		BioGRID	PubMed
Reconstituted Complex
BioGRID:107480	BioGRID:108403	ESR1		BioGRID	PubMed
Reconstituted Complex
BioGRID:107480	BioGRID:108597	FOXO1		BioGRID	PubMed
Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:109402	HMGA1		BioGRID	PubMed
Reconstituted Complex
BioGRID:107480	BioGRID:109431	HNRNPK		BioGRID	PubMed
Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:109530	HSF1		BioGRID	PubMed
Biochemical Activity
BioGRID:107480	BioGRID:111580	MAPK1		BioGRID	PubMed
Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:114829	MED23		BioGRID	PubMed
Affinity Capture-Western
BioGRID:107480	BioGRID:114831	MED26		BioGRID	PubMed
Co-crystal Structure
BioGRID:107480	BioGRID:110687	MYB		BioGRID	PubMed
Affinity Capture-Western
BioGRID:107480	BioGRID:110694	MYC		BioGRID	PubMed
Reconstituted Complex
BioGRID:107480	BioGRID:110857	NFKB1		BioGRID	PubMed
Phenotypic Enhancement; Reconstituted Complex
BioGRID:107480	BioGRID:114654	NOLC1		BioGRID	PubMed
Reconstituted Complex; Two-hybrid
BioGRID:107480	BioGRID:109165	NR3C1		BioGRID	PubMed
Reconstituted Complex
BioGRID:107480	BioGRID:111850	RARB		BioGRID	PubMed
Reconstituted Complex
BioGRID:107480	BioGRID:111860	RB1		BioGRID	PubMed
Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:111902	RELA		BioGRID	PubMed
Reconstituted Complex
BioGRID:107480	BioGRID:107309	RUNX1		BioGRID	PubMed
Reconstituted Complex
BioGRID:107480	BioGRID:110263	SMAD3		BioGRID	PubMed
Reconstituted Complex
BioGRID:107480	BioGRID:110264	SMAD4		BioGRID	PubMed
Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:112479	SMARCA2		BioGRID	PubMed
Affinity Capture-Western
BioGRID:107480	BioGRID:112483	SMARCC1		BioGRID	PubMed
Affinity Capture-Western
BioGRID:107480	BioGRID:112550	SP1		BioGRID	PubMed
Reconstituted Complex
BioGRID:107480	BioGRID:112566	SPI1		BioGRID	PubMed
Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:107480	BioGRID:112600	SRF		BioGRID	PubMed
Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:115457	TRIM28		BioGRID	PubMed

[Top][Help]General gene information

Markers

RH17476(e-PCR): Links: UniSTS:79118

D20S728(e-PCR): Links: UniSTS:3208

STS-H26183(e-PCR): Links: UniSTS:32399

Genotypes

See CEBPB SNP Genotype Report

See CEBPB SNP Geneview Report

Homology

Homologs of the CEBPB gene The CEBPB gene is conserved in chimpanzee, mouse, rat, chicken, and zebrafish.

Map Viewer (Mouse, Rat)

Gene Ontology Provided by GOA

Function	Evidence
RNA polymerase II transcription factor activity, enhancer binding	ISS
protein heterodimerization activity	IEA
protein homodimerization activity	IEA
sequence-specific DNA binding	IEA
transcription activator activity	IEA

Process	Evidence
acute-phase response	TAS	PubMed
anti-apoptosis	IEA
embryonic placenta development	IEA
fat cell differentiation	IEA
immune response	TAS	PubMed
induction of apoptosis	IEA
inflammatory response	TAS	PubMed
neuron differentiation	IEA
positive regulation of transcription	IEA
positive regulation of transcription from RNA polymerase II promoter	IEA
regulation of interleukin-6 biosynthetic process	IEA
regulation of transcription, DNA-dependent	IEA

Component	Evidence
cytoplasm	IEA
nuclear matrix	IEA
nucleus	TAS	PubMed

[Top][Help]General protein information

Preferred Names: CCAAT/enhancer binding protein beta

Names: CCAAT/enhancer binding protein beta; transcription factor 5; nuclear factor of interleukin 6; interleukin 6-dependent DNA-binding protein; liver-enriched transcriptional activator protein

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

NM_005194.2 → NP_005185.2 CCAAT/enhancer binding protein beta

Source sequence(s)

BC021931,BU753628

Consensus CDS

CCDS13429.1

UniProtKB/TrEMBL

A8K671

UniProtKB/Swiss-Prot

P17676

Conserved Domains (1) summary

cl02576
Location:270 – 323
Blast Score: 191

bZIP_1; bZIP transcription factor

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

NC_000020.10

Range

48807375..48809211

Download

GenBank FASTA Sequence Viewer (Graphics)
NT_011362.10

Range

19003467..19005303

Download

GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

AC_000063.1

Range

45511632..45513468

Download

GenBank FASTA Sequence Viewer (Graphics)
NW_927339.1

Range

19014741..19016577

Download

GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

AC_000152.1

Range

45555688..45557579

Download

GenBank FASTA Sequence Viewer (Graphics)
NW_001838666.1

Range

11876537..11878428

Download

GenBank FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

Nucleotide		Protein
genomic	AL161937.13	CAC14276.1
genomic	AY193834.1	AAN86350.1
genomic	CH471077.2	EAW75629.1
genomic	X52560.1	CAA36794.1
mRNA	AF289608.1	AAL55792.1
mRNA	AK291536.1	BAF84225.1
mRNA	BC005132.2	AAH05132.2
mRNA	BC007538.1	AAH07538.1
mRNA	BC021931.1	AAH21931.1
mRNA	BU753628.1	None
mRNA	CR595646.1	None
mRNA	CR596985.1	None
mRNA	CR606949.1	None
mRNA	CR611012.1	None
mRNA	CR614073.1	None
mRNA	CR617287.1	None
mRNA	D63161.1	BAA09637.1
mRNA	M98056.1	None
other-genetic	EU832661.1	ACE87752.1
other-genetic	EU832739.1	ACE87071.1