Items 1 - 20 of 54
of 3Next
1: GDS2517 record: Hyperhomocysteinemia model: heart [Canis lupus familiaris] GEO Profiles, Links
Summary:Analysis of hearts of animals given drinking water containing 10 g/L of L-methionine to induce chronic hyperhomocysteinemia (HHcy). HHcy is characterized by an elevation in plasma homocysteine, and is a risk factor for atherosclerosis. Results provide insight into the impact of HHcy on the heart.
Parent Platform: GPL3979
Reference Series: GSE5260
Type:Expression profiling by array, count
Subsets: 2 disease state sets.
Supplementary Files: CEL download...
Samples:8
2: GDS2424 record: Pacing-induced heart failure model: time course [Canis lupus familiaris] GEO Profiles, Links
Summary:Analysis of hearts of animals subjected to chronic cardiac pacing for 3 or 4 weeks. The transition from compensated dysfunction to decompensated heart failure (HF) occurs between the third and fourth week of pacing. Results provide insight into the progression to decompensated HF.
Parent Platform: GPL3979
Reference Series: GSE5247
Type:Expression profiling by array, count
Subsets: 2 protocol, 3 time sets.
Supplementary Files: CEL download...
Samples:12
  • GSM118683: D5-canine Control
  • GSM118685: D6-canine Control
  • GSM118688: D7-canine Control
  • GSM118690: D8-canine Control
  • GSM118691: D9-canine 3 weeks Pacing induced heart failure
  • GSM118692: D10-canine 3 weeks Pacing induced heart failure
  • GSM118693: D11-canine 3 weeks Pacing induced heart failure
  • GSM118694: D12-canine 3 weeks Pacing induced heart failure
  • GSM118670: D1-canine 4 weeks Pacing induced heart failure
  • GSM118675: D2-canine 4 weeks Pacing induced heart failure
  • GSM118678: D3-canine 4 weeks Pacing induced heart failure
  • GSM118680: D4-canine 4 weeks Pacing induced heart failure
3: GDS406 record: Hepatocyte growth factor-treated kidney cells [Canis lupus familiaris] GEO Profiles, Links
Summary:Cultured Madin-Darby canine kidney (MDCK) cells treated with hepatocyte growth factor (HGF) for 0, 3 and 24 hours.
Parent Platform: GPL374
Reference Series: GSE578
Type:Expression profiling by array, count
Subsets: 3 time sets.
Samples:9
4: GDS213 record: Congestive heart failure [Homo sapiens; Canis lupus familiaris] GEO Profiles, Links
Summary:Analysis of canine tachycardia-induced cardiomyopathy caused by several weeks of rapid ventricular pacing. Left ventricular free wall samples from control dogs and dogs with pacing-induced heart failure compared.
Parent Platform: GPL246
Reference Series: GSE472
Type:Expression profiling by array, count
Subsets: 2 disease state sets.
Supplementary Files: CEL download...
Samples:5
5: GSE16102 record: Gene expression profiles of canine and human osteosarcoma [Homo sapiens; Canis lupus familiaris] Links
Summary:(Submitter supplied) This SuperSeries is composed of the following subset Series: GSE16087: Gene expression profiles of canine osteosarcoma GSE16088: Gene expression profiles of human osteosarcoma GSE16091: Gene expression profiles of human osteosarcoma, set2 Pulmonary metastasis continues to be the most common cause of death in osteosarcoma. Indeed, the 5-year survival for newly diagnosed osteosarcoma patients has not significantly changed in over 20 years. Further understanding of the mechanisms of metastasis and resistance for this aggressive pediatric cancer is necessary. Pet dogs naturally develop osteosarcoma providing a novel opportunity to model metastasis development and progression. Given the accelerated biology of canine osteosarcoma, we hypothesized that a direct comparison of canine and pediatric osteosarcoma expression profiles may help identify novel metastasis-associated tumor targets that have been missed through the study of the human cancer alone. more...
2 related Platforms
Type:Expression profiling by array
Supplementary Files: CEL download...
Samples:80
6: GSE16087 record: Gene expression profiles of canine osteosarcoma [Canis lupus familiaris] Links
Summary:(Submitter supplied) Pulmonary metastasis continues to be the most common cause of death in osteosarcoma. Indeed, the 5-year survival for newly diagnosed osteosarcoma patients has not significantly changed in over 20 years. Further understanding of the mechanisms of metastasis and resistance for this aggressive pediatric cancer is necessary. Pet dogs naturally develop osteosarcoma providing a novel opportunity to model metastasis development and progression. Given the accelerated biology of canine osteosarcoma, we hypothesized that a direct comparison of canine and pediatric osteosarcoma expression profiles may help identify novel metastasis-associated tumor targets that have been missed through the study of the human cancer alone. Collectively, these data support the strong similarities between human and canine osteosarcoma and underline the opportunities provided by a comparative oncology approach as a means to improve our understanding of cancer biology and therapy.
1 related Platform
Type:Expression profiling by array
Supplementary Files: CEL download...
Samples:23
7: GSE18317 record: Mapping DNA structural variation in dogs [Canis lupus familiaris] Links
Summary:(Submitter supplied) DNA structural variation (SV) comprises a major portion of genetic diversity, but its biological impact is unclear. We propose that the genetic history and extraordinary phenotypic variation of dogs make them an ideal mammal in which to study the effects of SV on biology and disease. The hundreds of existing dog breeds were created by selection of extreme morphological and behavioral traits. And along with those traits, each breed carries increased risk for different diseases. We used array CGH to create the first map of DNA copy number variation (CNV) or SV in dogs. The extent of this variation, and some of the gene classes affected, are similar to those of mice and humans. Most canine CNVs affect genes, including disease and candidate disease genes, and are thus likely to be functional. We identified many CNVs that may be breed or breed class specific. more...
1 related Platform
Type:Genome variation profiling by genome tiling array
Supplementary Files: PAIR download...
Samples:10
8: GSE14033 record: Gene expression profiling of canine osteosarcoma reveals genes associated with short and long survival times [Canis lupus familiaris] Links
Summary:(Submitter supplied) Osteosarcoma (OS) accounts for approximately 80% of all malignant bone tumors in the dog. Tumors are highly metastatic and long-term survival is poor. This study aims to investigate the prognosis associated gene expression profile in primary canine OS. Canine specific cDNA microarray representing 20,313 genes was used to analyze expression profiles in a panel of thirty-two primary osteosarcoma to identify genes associated with survival. The 32 tumours were classified into two groups of prognosis based on survival time (ST). They were defined as short survivors (dogs with poor prognosis that survived less than 6 months) and long survivors (dogs with better prognosis that survived longer than 6 months). Fifty-one genes were found to be differentially expressed, with common up regulation of these genes in the short survivors. more...
1 related Platform
Type:Expression profiling by array
Samples:32
9: GSE15117 record: Temporal pattern of skeletal muscle gene expression following endurance exercise in Alaskan sled dogs [Canis lupus familiaris] Links
Summary:(Submitter supplied) Background: Muscle responses to exercise are complex, and potentially include acute responses to exercise-induced injury as well as longer-term adaptive training responses. Using Alaskan sled dogs as an experimental model, changes in muscle gene expression were analyzed to better understand the temporal changes that occur after severe exercise. Methods: Dogs were randomly assigned to undertake in a 160 km run (n=9), or to remain at rest (n=4). Biceps femoris muscle was obtained by needle biopsy from the unexercised dogs and two dogs at each of 2, 6 and 12 hours after the exercise and from 3 dogs 24 hours after exercise. RNA was extracted and microarray analysis used to define gene transcriptional changes. Results: Nine hundred sixty three transcripts exhibited statistically significant change over time after exercise as compared to the unexercised dogs. more...
1 related Platform
Type:Expression profiling by array
Supplementary Files: TXT download...
Samples:13
  • GSM377776: Dog Biceps femoris Unexercised Control Pool (n=4) vs. Biceps femoris; 0000 min (Not Exercised); Dog #02
  • GSM377787: Dog Biceps femoris Unexercised Control Pool (n=4) vs. Biceps femoris; 1495 min (24h Post Exercise); Dog #13
  • GSM377784: Dog Biceps femoris Unexercised Control Pool (n=4) vs. Biceps femoris; 0762 min (12h Post Exercise); Dog #06
  • GSM377785: Dog Biceps femoris Unexercised Control Pool (n=4) vs. Biceps femoris; 1450 min (24h Post Exercise); Dog #05
  • GSM377782: Dog Biceps femoris Unexercised Control Pool (n=4) vs. Biceps femoris; 0415 min (06h Post Exercise); Dog #10
  • GSM377779: Dog Biceps femoris Unexercised Control Pool (n=4) vs. Biceps femoris; 0070 min (02h Post Exercise); Dog #08
  • GSM377778: Dog Biceps femoris Unexercised Control Pool (n=4) vs. Biceps femoris; 0000 min (Not Exercised); Dog #04
  • GSM377781: Dog Biceps femoris Unexercised Control Pool (n=4) vs. Biceps femoris; 0395 min (06h Post Exercise); Dog #09
  • GSM377775: Dog Biceps femoris Unexercised Control Pool (n=4) vs. Biceps femoris; 0000 min (Not Exercised); Dog #01
  • GSM377786: Dog Biceps femoris Unexercised Control Pool (n=4) vs. Biceps femoris; 1476 min (24h Post Exercise); Dog #14
  • GSM377783: Dog Biceps femoris Unexercised Control Pool (n=4) vs. Biceps femoris; 0735 min (12h Post Exercise); Dog #07
  • GSM377780: Dog Biceps femoris Unexercised Control Pool (n=4) vs. Biceps femoris; 0095 min (02h Post Exercise); Dog #11
  • GSM377777: Dog Biceps femoris Unexercised Control Pool (n=4) vs. Biceps femoris; 0000 min (Not Exercised); Dog #03
10: GSE16049 record: Expression in myocardial tissues of Great Dane dogs with cardiomyopathy [Canis lupus familiaris] Links
Summary:(Submitter supplied) Oligonucleotide microarray analysis of left ventricular tissues from 3 Great dane dogs with dilated cardiomyopathy and 3 control dogs was performed. Three hundred and twenty three differentially expressed transcripts were detected. The transcript demonstrating the highest degree of upregulation was FKBP12.6 (calstabin2) and the transcript with the greatest amount of down regulation was triadin. Both of these transcripts are critical to proper functioning of the cardiac ryanodine receptor. Abnormalities of both calstabin2 and triadin have been reported in humans with heart disease. Further investigation into the role of calstabin2 and triadin in canine cardiomyopathy is warranted, and the canine disease may serve as a model of human disease. Keywords: control vs diseased
1 related Platform
Type:Expression profiling by array
Supplementary Files: CEL CHP download...
Samples:6
11: GSE14999 record: Gene expression profiling of human and dog breast cancers [Homo sapiens; Canis lupus familiaris] Links
Summary:(Submitter supplied) Spontaneous tumors in dog have been demonstrated to share many features with their human counterparts, including relevant molecular targets, histological appearance, genetics, biological behavior and response to conventional treatments. Mammary tumors in dog therefore provide an attractive alternative to more classical mouse models, such as transgenics or xenografts, where the tumour is artificially induced. To assess the extent to which dog tumors represent clinically significant human phenotypes, we performed the first genome-wide comparative analysis of transcriptional changes occurring in mammary tumors of the two species, with particular focus on the molecular pathways involved. Keywords: Expression profiling by array
2 related Platforms
Type:Expression profiling by array
Samples:162
12: GSE15086 record: Gene Expression Profiles of Sporadic Canine Hemangiosarcoma are Uniquely Associated with Breed [Canis lupus familiaris] Links
Summary:(Submitter supplied) Abnormal function of genes is at the root of most cancers, but heritable cancer syndromes account for a very small minority of all tumors in humans and domestic animals. The majority of cancers are “sporadic,” that is, they are not heritable in the strictest sense. Instead, sporadic cancers occur due to interactions of unknown intrinsic (heritable) and environmental factors that lead to malignant transformation and uncontrolled growth. Identification of heritable risk factors in sporadic human cancers is difficult because individual genetic backgrounds are very heterogeneous. To this end, individual genetic backgrounds of purebred dogs are more homogeneous, and dog breeds show different predilection to develop specific cancers. Here, we used genomic screens based on gene expression profiling to identify sets of genes that may contribute to the development of canine hemangiosarcoma, a relatively common endothelial sarcoma. more...
1 related Platform
Type:Expression profiling by array
Supplementary Files: CEL download...
Samples:10
  • GSM377398: Golden Retriever, hemangiosarcoma: ChadG4
  • GSM377406: Rottweiler, hemangiosarcoma: Joey
  • GSM377404: Portugese Water Dog, hemangiosarcoma: ChadP9
  • GSM377401: Golden Retriever, hemangiosarcoma: Frog
  • GSM377402: Golden Retriever, hemangiosarcoma: Journey
  • GSM377405: Dalmation, hemangiosarcoma: Dal4
  • GSM377399: Golden Retriever, hemangiosarcoma: ChadG6
  • GSM377403: Golden Retriever, hemangiosarcoma: Tucker
  • GSM377407: Mix breed, hemangiosarcoma: DD1
  • GSM377400: Golden Retriever, hemangiosarcoma: ChadG8
13: GSE13754 record: Gene expression profiles of progestin-induced canine mammary hyperplasia and spontaneous mammary tumors [Canis lupus familiaris] Links
Summary:(Submitter supplied) Spontaneous mammary tumours are the most prevalent type of neoplasm in women as well as in female dogs. Even though ovarian hormones, mainly estrogens and progestins, are known to play a key role in mammary tumorigenesis, conflicting reports have been obtained from in vivo and in vitro studies concerning their role, especially of progestins, in mammary tumorigenesis. Prolonged exposure to high levels of progestins during unusually long luteal phase of oestrous cycle is suspected to be the key event in canine mammary tumorigenesis. Accordingly, our previous studies have shown development of mammary hyperplasia in dogs upon prolonged progestin administration. In this study, we used canine cDNA microarrays to identify oncogenic determinants in progestin-induced canine hyperplasia (CMH) and spontaneous tumours (CMC) by comparing them to normal tissue. more...
1 related Platform
Type:Expression profiling by array
Supplementary Files: TXT download...
Samples:37
14: GSE9145 record: E-cadherin and EMT regulation by bHLH factors: a new role for the class I gene E2-2 (TCF4) and its comparison with E47. [Homo sapiens; Canis lupus familiaris] Links
Summary:(Submitter supplied) Loss of expression of the cell-cell adhesion molecule E-cadherin is an essential event for epithelial-mesenchymal transition (EMT), a process that allows cell migration in the developing embryo and during tumour invasion. Transcriptional repression has emerged as the main mechanism responsible for E-cadherin downregulation in most carcinomas. Recently, we have identified the class I HLH transcriptional regulator E2-2 (ITF2), in a yeast one hybrid screen designed to identify transcriptional repressors interacting with the E-pal element of the murine E-cadherin promoter. The E2-2 gene codifies two isoforms that differ in their N-terminal regions but their specific functions remain unknown. In the present work we show that both E2-2A and E2-2B induce a complete EMT, in MDCK cells, with loss of E-cadherin expression, gain of mesenchymal markers and acquisition of motile and invasive properties. more...
1 related Platform
Type:Expression profiling by array
Samples:4
15: GSE9147 record: E-cadherin and EMT regulation by E47 transcription represor [Homo sapiens; Canis lupus familiaris] Links
Summary:(Submitter supplied) Expression profile analysis in MDCK-E47 cells in comparisom with MDCK CMV control cells Keywords: Genetic Modification (overexpression of E-cadherin repressors)
1 related Platform
Type:Expression profiling by array
Samples:3
16: GSE9606 record: Lungs of ferrets infected with either an H3N2 or H5N1 subtype of influenza A virus. [Canis lupus familiaris; Mustela putorius furo] Links
Summary:(Submitter supplied) A global genomics approach was used to identify patterns of immune dysregulation during H5N1 influenza virus infection as the host response, in particular hyperchemokinemia, is thought to contribute to the extreme pathology associated with this disease. Keywords: time course
1 related Platform
Type:Expression profiling by array
Supplementary Files: CEL download...
Samples:23
  • GSM242965: Ferret lung with H3N2 at Day 0, biological rep1
  • GSM242982: Ferret lung with H5N1 at Day 4, biological rep1
  • GSM242985: Ferret lung with H5N1 at Day 6, biological rep1
  • GSM242968: Ferret lung with H3N2 at Day 2, biological rep1
  • GSM242971: Ferret lung with H3N2 at Day 4, biological rep1
  • GSM242974: Ferret lung with H3N2 at Day 6, biological rep2
  • GSM242966: Ferret lung with H3N2 at Day 0, biological rep2
  • GSM242969: Ferret lung with H3N2 at Day 2, biological rep2
  • GSM242972: Ferret lung with H3N2 at Day 4, biological rep2
  • GSM242981: Ferret lung with H5N1 at Day 2, biological rep3
  • GSM242984: Ferret lung with H5N1 at Day 4, biological rep3
  • GSM242975: Ferret lung with H3N2 at Day 6, biological rep3
  • GSM242978: Ferret lung with H5N1 at Day 0, biological rep3
  • GSM242987: Ferret lung with H5N1 at Day 6, biological rep3
  • GSM242973: Ferret lung with H3N2 at Day 6, biological rep1
  • GSM242976: Ferret lung with H5N1 at Day 0, biological rep1
  • GSM242979: Ferret lung with H5N1 at Day 2, biological rep1
  • GSM242977: Ferret lung with H5N1 at Day 0, biological rep2
  • GSM242980: Ferret lung with H5N1 at Day 2, biological rep2
  • GSM242983: Ferret lung with H5N1 at Day 4, biological rep2
  • GSM242986: Ferret lung with H5N1 at Day 6, biological rep2
  • GSM242967: Ferret lung with H3N2 at Day 0, biological rep3
  • GSM242970: Ferret lung with H3N2 at Day 2, biological rep3
17: GSE13266 record: Canine CNVs associated with canFam2 segmental duplications [Canis lupus; Canis lupus familiaris] Links
Summary:(Submitter supplied) This study centered on using a custom made Nimblegen aCGH chip that targeted all segmental duplications in the canine genome to identify associated CNVs. A total of 19 hybridizations were performed in a panel of diverse dogs and a single wolf.
1 related Platform
Type:Genome variation profiling by genome tiling array
Supplementary Files: PAIR TXT download...
Samples:19
18: GSE13253 record: Localized Rho GTPase Activation Regulates RNA Dynamics and Compartmentalization in Tumor Cell Protrusions [Canis lupus familiaris] Links
Summary:(Submitter supplied) mRNA trafficking and local protein translation are associated with protrusive cellular domains, such as neuronal growth cones, and deregulated control of protein translation is associated with tumor malignancy. We show here that activated RhoA, but not Rac1, is enriched in pseudopodia of MSV-MDCK-INV tumor cells and that Rho, Rho kinase (ROCK) and myosin II regulate the microtubule-independent targeting of RNA to these tumor cell domains. ROCK inhibition does not affect pseudopodial actin turnover but significantly reduces the dynamics of pseudopodial RNA turnover. Gene array analysis shows that 7.3% of the total genes analyzed exhibited a greater than 1.6-fold difference between the pseudopod and cell body fractions. Of these, only 13.2% (261 genes) are enriched in pseudopodia, suggesting that only a limited number of total cellular mRNAs are enriched in tumor cell protrusions. more...
1 related Platform
Type:Expression profiling by array
Supplementary Files: CEL TXT download...
Samples:6
19: GSE11156 record: Characterizing the expression of Pan troglodytes olfactory receptor genes [Pan troglodytes; Homo sapiens; Canis lupus familiaris; Rattus norvegicus] Links
Summary:(Submitter supplied) We aim, among other things, to characterize olfactory receptor (OR) genes wich are differentially expressed between olfactory epithelium (OE) and other organ tissues, in chimpanzees (Pan troglodytes), and to make comparisons with human data from a previous series using the same platform. Keywords: Comparative
1 related Platform
Type:Expression profiling by array
Supplementary Files: CEL download...
Samples:12
20: GSE9794 record: Progression of heart failure induced by tachycardia [Canis lupus familiaris] Links
Summary:(Submitter supplied) Analysis of changes of gene expression profiles in the left ventricle (LV) during the progression of heart failure (HF) in the canine tachypacing induced HF model. Gene expression profiling was performed on samples collected at different time points representing various stages of LV dysfunction, i.e. tachypaced for 3 days (Day-3), 1 week (Week-1), 2 weeks (Week-2), 3-4 weeks (End stage), and unpaced controls (Day-0). Results provide insights into molecular mechanisms of heart failure progression. Keywords: time course
1 related Platform
Type:Expression profiling by array
Supplementary Files: CEL CHP download...
Samples:45
  • GSM247322: Ventricle tissue at Week-2, biological replicate 1, technical replicate 1
  • GSM247308: Ventricle tissue at Day-3, biological replicate 2, technical replicate 2
  • GSM247305: Ventricle tissue at Day-3, biological replicate 1, technical replicate 2
  • GSM247302: Ventricle tissue at Day-0, biological replicate 3, technical replicate 2
  • GSM247328: Ventricle tissue at Week-2, biological replicate 3, technical replicate 1
  • GSM247325: Ventricle tissue at Week-2, biological replicate 2, technical replicate 1
  • GSM247311: Ventricle tissue at Day-3, biological replicate 3, technical replicate 2
  • GSM247334: Ventricle tissue at End-stage, biological replicate 2, technical replicate 1
  • GSM247331: Ventricle tissue at End-stage, biological replicate 1, technical replicate 1
  • GSM247300: Ventricle tissue at Day-0, biological replicate 2, technical replicate 3
  • GSM247337: Ventricle tissue at End-stage, biological replicate 3, technical replicate 1
  • GSM247323: Ventricle tissue at Week-2, biological replicate 1, technical replicate 2
  • GSM247297: Ventricle tissue at Day-0, biological replicate 1, technical replicate 3
  • GSM247303: Ventricle tissue at Day-0, biological replicate 3, technical replicate 3
  • GSM247329: Ventricle tissue at Week-2, biological replicate 3, technical replicate 2
  • GSM247326: Ventricle tissue at Week-2, biological replicate 2, technical replicate 2
  • GSM247318: Ventricle tissue at Week-1, biological replicate 2, technical replicate 3
  • GSM247309: Ventricle tissue at Day-3, biological replicate 2, technical replicate 3
  • GSM247306: Ventricle tissue at Day-3, biological replicate 1, technical replicate 3
  • GSM247295: Ventricle tissue at Day-0, biological replicate 1, technical replicate 1
  • GSM247332: Ventricle tissue at End-stage, biological replicate 1, technical replicate 2
  • GSM247315: Ventricle tissue at Week-1, biological replicate 1, technical replicate 3
  • GSM247338: Ventricle tissue at End-stage, biological replicate 3, technical replicate 2
  • GSM247312: Ventricle tissue at Day-3, biological replicate 3, technical replicate 3
  • GSM247335: Ventricle tissue at End-stage, biological replicate 2, technical replicate 2
  • GSM247324: Ventricle tissue at Week-2, biological replicate 1, technical replicate 3
  • GSM247321: Ventricle tissue at Week-1, biological replicate 3, technical replicate 3
  • GSM247313: Ventricle tissue at Week-1, biological replicate 1, technical replicate 1
  • GSM247310: Ventricle tissue at Day-3, biological replicate 3, technical replicate 1
  • GSM247299: Ventricle tissue at Day-0, biological replicate 2, technical replicate 2
  • GSM247296: Ventricle tissue at Day-0, biological replicate 1, technical replicate 2
  • GSM247319: Ventricle tissue at Week-1, biological replicate 3, technical replicate 1
  • GSM247316: Ventricle tissue at Week-1, biological replicate 2, technical replicate 1
  • GSM247339: Ventricle tissue at End-stage, biological replicate 3, technical replicate 3
  • GSM247314: Ventricle tissue at Week-1, biological replicate 1, technical replicate 2
  • GSM247320: Ventricle tissue at Week-1, biological replicate 3, technical replicate 2
  • GSM247317: Ventricle tissue at Week-1, biological replicate 2, technical replicate 2
  • GSM247304: Ventricle tissue at Day-3, biological replicate 1, technical replicate 1
  • GSM247301: Ventricle tissue at Day-0, biological replicate 3, technical replicate 1
  • GSM247298: Ventricle tissue at Day-0, biological replicate 2, technical replicate 1
  • GSM247333: Ventricle tissue at End-stage, biological replicate 1, technical replicate 3
  • GSM247307: Ventricle tissue at Day-3, biological replicate 2, technical replicate 1
  • GSM247330: Ventricle tissue at Week-2, biological replicate 3, technical replicate 3
  • GSM247327: Ventricle tissue at Week-2, biological replicate 2, technical replicate 3
  • GSM247336: Ventricle tissue at End-stage, biological replicate 2, technical replicate 3
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