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miR-579-3p controls melanoma progression and resistance to target therapy.
Fattore L, Mancini R, Acunzo M, Romano G, Laganà A, Pisanu ME, Malpicci D, Madonna G, Mallardo D, Capone M, Fulciniti F, Mazzucchelli L, Botti G, Croce CM, Ascierto PA, Ciliberto G. Fattore L, et al. Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E5005-13. doi: 10.1073/pnas.1607753113. Epub 2016 Aug 8. Proc Natl Acad Sci U S A. 2016. PMID: 27503895 Free PMC article.
Mutational events, as well as adaptive mechanisms, contribute to the development of drug resistance. In this context we uncover here the role of a miRNA, miR-579-3p. We first show that low expression of miR-579-3p is a negative prognostic …
Mutational events, as well as adaptive mechanisms, contribute to the development of drug resistance. In this context we uncover here the rol …
LncRNA HCG11/miR-579-3p/MDM2 axis modulates malignant biological properties in pancreatic carcinoma via Notch/Hes1 signaling pathway.
Xu J, Xu W, Yang X, Liu Z, Sun Q. Xu J, et al. Aging (Albany NY). 2021 Jun 21;13(12):16471-16484. doi: 10.18632/aging.203167. Epub 2021 Jun 21. Aging (Albany NY). 2021. PMID: 34230221 Free PMC article.
Bioinformatics analysis was applied to detect the associations among HCG11/miR-579-3p/MDM2. The malignant properties of pancreatic carcinoma cells were measured by numerous biological assays. ...Bioinformatics analysis revealed that HCG11 upregulated MDM2 exp …
Bioinformatics analysis was applied to detect the associations among HCG11/miR-579-3p/MDM2. The malignant properties of …
miR-579-3p Controls Hepatocellular Carcinoma Formation by Regulating the Phosphoinositide 3-Kinase-Protein Kinase B Pathway in Chronically Inflamed Liver.
Quintavalle C, Meyer-Schaller N, Roessler S, Calabrese D, Marone R, Riedl T, Picco-Rey S, Panagiotou OA, Uzun S, Piscuoglio S, Boldanova T, Bian CB, Semela D, Jochum W, Cathomas G, Mertz KD, Diebold J, Mazzucchelli L, Koelzer VH, Weber A, Decaens T, Terracciano LM, Heikenwalder M, Hoshida Y, Andersen JB, Thorgeirsson SS, Matter MS. Quintavalle C, et al. Hepatol Commun. 2022 Jun;6(6):1467-1481. doi: 10.1002/hep4.1894. Epub 2022 Feb 8. Hepatol Commun. 2022. PMID: 35132819 Free PMC article.
Comparison of the two cohorts revealed that liver tissue from patients developing HCC displayed a down-regulation of miR-579-3p as an early step in HCC development, which was further confirmed in a validation cohort. ...In vitro experiments and the use of clu …
Comparison of the two cohorts revealed that liver tissue from patients developing HCC displayed a down-regulation of miR-579- …
Role of miR-579-3p in the development of squamous cell lung carcinoma and the regulatory mechanisms.
Wu RR, Zhong Q, Liu HF, Liu SB. Wu RR, et al. Eur Rev Med Pharmacol Sci. 2019 Nov;23(21):9464-9470. doi: 10.26355/eurrev_201911_19440. Eur Rev Med Pharmacol Sci. 2019. PMID: 31773684 Free article.
MiR-579-3p expression in SCLC cells was further verified by qRT-PCR as well. ...RESULTS: QRT-PCR results revealed for the first time that miR-579-3p was significantly down-regulated in SCLC tissues. This indicated that miR-579 …
MiR-579-3p expression in SCLC cells was further verified by qRT-PCR as well. ...RESULTS: QRT-PCR results revealed for t …
Circ_0007706 downregulation ameliorates neonatal hypoxic ischemic encephalopathy via regulating the miR-579-3p/TRAF6 axis.
Wang J, Hua M, Li H, Xu D, Li F, Xu F. Wang J, et al. Brain Res Bull. 2023 Mar;194:90-99. doi: 10.1016/j.brainresbull.2023.01.013. Epub 2023 Jan 30. Brain Res Bull. 2023. PMID: 36720318 Free article.
Knockdown of circ_0007706 greatly alleviated OGD/R-induced injury, inflammatory response and oxidative stress. We found that miR-579-3p was a direct target of circ_0007706, and miR-579-3p inhibitor could reverse the impact of circ_0007706 …
Knockdown of circ_0007706 greatly alleviated OGD/R-induced injury, inflammatory response and oxidative stress. We found that miR-5 …
LncRNA GAS5 inhibits miR-579-3p to activate SIRT1/PGC-1alpha/Nrf2 signaling pathway to reduce cell pyroptosis in sepsis-associated renal injury.
Ling H, Li Q, Duan ZP, Wang YJ, Hu BQ, Dai XG. Ling H, et al. Am J Physiol Cell Physiol. 2021 Jul 1;321(1):C117-C133. doi: 10.1152/ajpcell.00394.2020. Epub 2021 May 19. Am J Physiol Cell Physiol. 2021. PMID: 34010066 Free article.
GAS5 negatively and directly regulated miR-579-3p to reduce cell pyroptosis via the activation of SIRT1/PGC-1a/Nrf2 pathway. In addition, miR-579-3p suppressed PGC-1a/Nrf2 pathway to induce cell pyroptosis by directly targeting SIRT1. ...
GAS5 negatively and directly regulated miR-579-3p to reduce cell pyroptosis via the activation of SIRT1/PGC-1a/Nrf2 pat …
Circ_0001490/miR-579-3p/FSTL1 axis modulates the survival of mycobacteria and the viability, apoptosis and inflammatory response in Mycobacterium tuberculosis-infected macrophages.
Deng Q, Huang J, Yan J, Mao E, Chen H, Wang C. Deng Q, et al. Tuberculosis (Edinb). 2021 Dec;131:102123. doi: 10.1016/j.tube.2021.102123. Epub 2021 Sep 3. Tuberculosis (Edinb). 2021. PMID: 34555658
Circ_0001490 overexpression suppressed M.tb survival and promoted the viability and inflammatory response of THP-1 macrophages. Circ_0001490 interacted with microRNA-579-3p (miR-579-3p), and circ_0001490 overexpression-induced protective effects in M.tb-infec …
Circ_0001490 overexpression suppressed M.tb survival and promoted the viability and inflammatory response of THP-1 macrophages. Circ_0001490 …
The MITF/mir-579-3p regulatory axis dictates BRAF-mutated melanoma cell fate in response to MAPK inhibitors.
Liguoro D, Frigerio R, Ortolano A, Sacconi A, Acunzo M, Romano G, Nigita G, Bellei B, Madonna G, Capone M, Ascierto PA, Mancini R, Ciliberto G, Fattore L. Liguoro D, et al. Cell Death Dis. 2024 Mar 12;15(3):208. doi: 10.1038/s41419-024-06580-2. Cell Death Dis. 2024. PMID: 38472212 Free PMC article.
In particular we show that miR-579-3p is specifically deregulated in BRAF-mutant melanomas and that its expression levels mirror those of MITF. ...Moreover, miR-579-3p, by targeting BRAF, is able to stabilize MITF protein thus inducing it …
In particular we show that miR-579-3p is specifically deregulated in BRAF-mutant melanomas and that its expression leve …
Circ_0001093 promotes glutamine metabolism and cancer progression of esophageal squamous cell carcinoma by targeting miR-579-3p/glutaminase axis.
Qian CJ, Tong YY, Wang YC, Teng XS, Yao J. Qian CJ, et al. J Bioenerg Biomembr. 2022 Apr;54(2):119-134. doi: 10.1007/s10863-022-09935-6. Epub 2022 Mar 23. J Bioenerg Biomembr. 2022. PMID: 35322289
Mechanistically, circ_0001093 acted as a competing endogenous RNA (ceRNA) by sponging miR-579-3p, thereby increasing GLS expression. Furthermore, the inhibitory effects of circ_0001093 knockdown on the invasion, migration and glutamine metabolism were partly …
Mechanistically, circ_0001093 acted as a competing endogenous RNA (ceRNA) by sponging miR-579-3p, thereby increasing GL …
Inhibition of sepsis-induced acute kidney injury via the circITCH-miR-579-3p-ZEB2 axis.
Li Q, Wang T, Wang X, Ge XY, Yang T, Bai G, Wang W. Li Q, et al. Environ Toxicol. 2023 Jun;38(6):1217-1225. doi: 10.1002/tox.23682. Epub 2023 Mar 31. Environ Toxicol. 2023. PMID: 36999488
However, the function of circITCH in the development of sepsis-induced AKI is still unclear. The levels of circITCH, miR-579-3p and ZEB2 were examined by real-time PCR and immunoblotting. ...CircITCH overexpression restored cell viability in LPS-treated HK-2 …
However, the function of circITCH in the development of sepsis-induced AKI is still unclear. The levels of circITCH, miR-579- …
36 results