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The following term was not found in PubMed: ENSG00000174282
Page 1
Hypoxia derived exosomes promote the proliferation and metastasis of colorectal cancer through the regulation of HIF-1alpha/miR-4299/ZBTB4.
Wu L, Xue M, Lai S, Chen J, Lin Y, Ding N, Zhong J, Chen S, Wang L. Wu L, et al. Life Sci. 2023 Sep 15;329:121872. doi: 10.1016/j.lfs.2023.121872. Epub 2023 Jun 22. Life Sci. 2023. PMID: 37352917
The clinical significance of ZBTB4 was measured in tumor tissues and adjacent non-tumor tissues. ...The expression of ZBTB4 were decreased in tumor tissues compared with non-tumor colon tissues from patients. ...
The clinical significance of ZBTB4 was measured in tumor tissues and adjacent non-tumor tissues. ...The expression of ZBTB4 we …
Glioma glycolipid metabolism: MSI2-SNORD12B-FIP1L1-ZBTB4 feedback loop as a potential treatment target.
Dong W, Liu X, Yang C, Wang D, Xue Y, Ruan X, Zhang M, Song J, Cai H, Zheng J, Liu Y. Dong W, et al. Clin Transl Med. 2021 May;11(5):e411. doi: 10.1002/ctm2.411. Clin Transl Med. 2021. PMID: 34047477 Free PMC article.
ZBTB4 transcriptionally suppressed the expression of HK2 and ACLY by binding directly to the promoter regions. Additionally, ZBTB4 bound the MSI promoter region to transcriptionally suppress MSI2 expression, thereby forming an MSI2/SNORD12B/FIP1L1/ZBTB4 feedb …
ZBTB4 transcriptionally suppressed the expression of HK2 and ACLY by binding directly to the promoter regions. Additionally, ZBTB4 …
Expression of Zinc Finger and BTB Domain-Containing 4 in Colorectal Cancer and Its Clinical Significance.
Xiang T, He K, Wang S, Chen W, Li H. Xiang T, et al. Cancer Manag Res. 2020 Oct 5;12:9621-9626. doi: 10.2147/CMAR.S266529. eCollection 2020. Cancer Manag Res. 2020. PMID: 33116821 Free PMC article.
The overall survival (OS) and recurrence-free survival (RFS) in the ZBTB4-low group were significantly lower than those in the ZBTB4-high group (P=0.0007 and P=0.0077). CONCLUSION: The current findings showed that patients with high-expressed ZBTB4 in CRC tis …
The overall survival (OS) and recurrence-free survival (RFS) in the ZBTB4-low group were significantly lower than those in the ZBT …
Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer.
Kim K, Chadalapaka G, Lee SO, Yamada D, Sastre-Garau X, Defossez PA, Park YY, Lee JS, Safe S. Kim K, et al. Oncogene. 2012 Feb 23;31(8):1034-44. doi: 10.1038/onc.2011.296. Epub 2011 Jul 18. Oncogene. 2012. PMID: 21765466 Free PMC article.
The experimental results using MDA-MB-231 and MCF-7 human breast cancer cells confirm that miRNAs derived from these clusters, containing miR-17-5p, miR-20a, miR-106a, miR-106b and miR-93, negatively regulate ZBTB4 expression. Overexpression of ZBTB4 or restoration …
The experimental results using MDA-MB-231 and MCF-7 human breast cancer cells confirm that miRNAs derived from these clusters, containing mi …
Identification of ZBTB4 as an immunological biomarker that can inhibit the proliferation and invasion of pancreatic cancer.
Yang Z, Chen F, Wang F, Chen X, Zheng B, Liao X, Deng Z, Ruan X, Ning J, Li Q, Jiang H, Qin S. Yang Z, et al. BMC Cancer. 2023 Mar 22;23(1):263. doi: 10.1186/s12885-023-10749-x. BMC Cancer. 2023. PMID: 36949454 Free PMC article.
ZBTB4 had good diagnostic performance for pancreatic cancer in the clinic, and ZBTB4 protein expression was lost in pancreatic cancer tumor tissues. Cell experiments revealed that overexpression of ZBTB4 inhibited the proliferation, migration and invasion of …
ZBTB4 had good diagnostic performance for pancreatic cancer in the clinic, and ZBTB4 protein expression was lost in pancreatic …
Tumor suppressive ZBTB4 inhibits cell growth by regulating cell cycle progression and apoptosis in Ewing sarcoma.
Yu Y, Shang R, Chen Y, Li J, Liang Z, Hu J, Liu K, Chen C. Yu Y, et al. Biomed Pharmacother. 2018 Apr;100:108-115. doi: 10.1016/j.biopha.2018.01.132. Epub 2018 Feb 7. Biomed Pharmacother. 2018. PMID: 29425745
Moreover, ZBTB4 restoration suppressed the tumor growth of ES in mice. An inversely correlation between ZBTB4 and Survivin expression was observed in ES tissues. ...ZBTB4/Survivin axis might serve as a therapeutic target for ES....
Moreover, ZBTB4 restoration suppressed the tumor growth of ES in mice. An inversely correlation between ZBTB4 and Survivin exp …
METTL3-Mediated m(6)A RNA Methylation of ZBTB4 Interferes With Trophoblast Invasion and Maybe Involved in RSA.
Huang N, Gao Y, Zhang M, Guo L, Qin L, Liao S, Wang H. Huang N, et al. Front Cell Dev Biol. 2022 Jun 14;10:894810. doi: 10.3389/fcell.2022.894810. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35774226 Free PMC article.
Real-time quantitative PCR (RT-qPCR) was used to verify the level of mRNA of METTL3 and ZBTB4. MeRIP-qPCR was conducted to test the level of ZBTB4 m(6)A modification in two groups. ...To study whether METTL3 regulated the ZBTB4 expression by recognizing ZB …
Real-time quantitative PCR (RT-qPCR) was used to verify the level of mRNA of METTL3 and ZBTB4. MeRIP-qPCR was conducted to test the l …
Therapeutic Targeting of Overexpressed MiRNAs in Cancer Progression.
Lee SH, Brianna B. Lee SH, et al. Curr Drug Targets. 2022;23(13):1212-1218. doi: 10.2174/1389450123666220613163906. Curr Drug Targets. 2022. PMID: 35702768 Review.
Cancer cells are known to upregulate specific miRNAs to inhibit the expression of genes regulating the cell cycle, such as PTEN, FOXO1, SOX7, caspases, KLF4, TRIM8, and ZBTB4. Inhibition of these genes promotes cancer development and survival by inducing cell growth, migra …
Cancer cells are known to upregulate specific miRNAs to inhibit the expression of genes regulating the cell cycle, such as PTEN, FOXO1, SOX7 …
Loss of the Methyl-CpG-Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis.
Roussel-Gervais A, Naciri I, Kirsh O, Kasprzyk L, Velasco G, Grillo G, Dubus P, Defossez PA. Roussel-Gervais A, et al. Cancer Res. 2017 Jan 1;77(1):62-73. doi: 10.1158/0008-5472.CAN-16-1181. Epub 2016 Nov 4. Cancer Res. 2017. PMID: 27815388
Here, we report that decreased ZBTB4 expression correlates with high genome instability across many frequent human cancers. ...To extend these findings, we generated Zbtb4-deficient mice. Zbtb4(-/-) mice were smaller than their wild-type littermates. ...
Here, we report that decreased ZBTB4 expression correlates with high genome instability across many frequent human cancers. ...To ext …
Variants regulating ZBTB4 are associated with age-at-onset of Alzheimer's disease.
Blue EE, Yu CE, Thornton TA, Chapman NH, Kernfeld E, Jiang N, Shively KM, Buckingham KJ, Marvin CT, Bamshad MJ, Bird TD, Wijsman EM. Blue EE, et al. Genes Brain Behav. 2018 Jul;17(6):e12429. doi: 10.1111/gbb.12429. Epub 2017 Nov 20. Genes Brain Behav. 2018. PMID: 29045054 Free PMC article.
Among the 11 variants associated with AAO of AD in a larger sample of Germans from Russia, the strongest evidence implicated promoter variants influencing NCSTN on 1q23.3 and ZBTB4 on 17p13.2. The association between ZBTB4 and AAO of AD was replicated by multiple va …
Among the 11 variants associated with AAO of AD in a larger sample of Germans from Russia, the strongest evidence implicated promoter varian …
69 results