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1999 2
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2008 6
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306 results

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The following term was not found in PubMed: ENSG00000164161
Page 1
Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir.
Wang C, Hyams B, Allen NC, Cautivo K, Monahan K, Zhou M, Dahlgren MW, Lizama CO, Matthay M, Wolters P, Molofsky AB, Peng T. Wang C, et al. Immunity. 2023 Mar 14;56(3):576-591.e10. doi: 10.1016/j.immuni.2023.01.032. Epub 2023 Feb 22. Immunity. 2023. PMID: 36822205 Free PMC article.
Murine studies identified a stromal niche for TRLs that expresses Hhip, a disease-variant gene downregulated in emphysema. Stromal-specific deletion of Hhip induced the topographic expansion of TRLs in the lung that was mediated by a hyperactive hedgehog-IL-7 axis. …
Murine studies identified a stromal niche for TRLs that expresses Hhip, a disease-variant gene downregulated in emphysema. Stromal-sp …
Hedgehog/GLI Signaling Pathway: Transduction, Regulation, and Implications for Disease.
Sigafoos AN, Paradise BD, Fernandez-Zapico ME. Sigafoos AN, et al. Cancers (Basel). 2021 Jul 7;13(14):3410. doi: 10.3390/cancers13143410. Cancers (Basel). 2021. PMID: 34298625 Free PMC article. Review.
This pathway consists of a series of ligands (Shh, Ihh, and Dhh), transmembrane receptors (Ptch1 and Ptch2), transcription factors (GLI1-3), and signaling regulators (SMO, HHIP, SUFU, PKA, CK1, GSK3beta, etc.) that work in concert to repress (Ptch1, Ptch2, SUFU, PKA, CK1, …
This pathway consists of a series of ligands (Shh, Ihh, and Dhh), transmembrane receptors (Ptch1 and Ptch2), transcription factors (GLI1-3), …
lncRNA HHIP-AS1/HHIP modulates osteogenic differentiation of BM-MSCs by regulating Hedgehog signaling pathway.
Yin XH, Wang XY, Liu SC, Yan L, He BR, Hao DJ, Yang M, Liu ZK. Yin XH, et al. Aging (Albany NY). 2022 Nov 14;14(21):8839-8855. doi: 10.18632/aging.204381. Epub 2022 Nov 14. Aging (Albany NY). 2022. PMID: 36375472 Free PMC article.
In addition, the gene coding lncRNA HHIP-AS1 is located on the anti-sense of Hhip gene, implying the potential interaction between lncRNA HHIP-AS1 and HHIP mRNA. ...Through binding to HHIP mRNA, lncRNA HHIP-AS1 recruited ELAVL1 to HHIP …
In addition, the gene coding lncRNA HHIP-AS1 is located on the anti-sense of Hhip gene, implying the potential interaction bet …
The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors.
Bartl J, Zanini M, Bernardi F, Forget A, Blümel L, Talbot J, Picard D, Qin N, Cancila G, Gao Q, Nath S, Koumba IM, Wolter M, Kuonen F, Langini M, Beez T, Munoz C, Pauck D, Marquardt V, Yu H, Souphron J, Korsch M, Mölders C, Berger D, Göbbels S, Meyer FD, Scheffler B, Rotblat B, Diederichs S, Ramaswamy V, Suzuki H, Oro A, Stühler K, Stefanski A, Fischer U, Leprivier G, Willbold D, Steger G, Buell A, Kool M, Lichter P, Pfister SM, Northcott PA, Taylor MD, Borkhardt A, Reifenberger G, Ayrault O, Remke M. Bartl J, et al. Nat Commun. 2022 Jul 13;13(1):4061. doi: 10.1038/s41467-022-31574-z. Nat Commun. 2022. PMID: 35831316 Free PMC article.
HHIP-AS1 is actively transcribed from a bidirectional promoter shared with SHH regulator HHIP. Knockdown of HHIP-AS1 induces mitotic spindle deregulation impairing tumorigenicity in vitro and in vivo. ...
HHIP-AS1 is actively transcribed from a bidirectional promoter shared with SHH regulator HHIP. Knockdown of HHIP-AS1 in …
Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway.
Niu C, Chen Z, Kim KT, Sun J, Xue M, Chen G, Li S, Shen Y, Zhu Z, Wang X, Liang J, Jiang C, Cong W, Jin L, Li X. Niu C, et al. Autophagy. 2019 May;15(5):843-870. doi: 10.1080/15548627.2019.1569913. Epub 2019 Jan 27. Autophagy. 2019. PMID: 30653446 Free PMC article.
Abbreviations: 3-MA = 3-methyladenine; 8GLI BS-FL = 8GLI-binding site firefly luciferase; AAV = adeno-associated virus; AAV-Cdh5-sh-Atg7 = AAV vectors carrying shRNA against murine Atg7 under control of murine Cdh5 promoter; AAV-Cdh5-sh-Gli1 = AAV vectors carrying shRNA against m …
Abbreviations: 3-MA = 3-methyladenine; 8GLI BS-FL = 8GLI-binding site firefly luciferase; AAV = adeno-associated virus; AAV-Cdh5-sh-Atg7 = A …
Hedgehog interacting protein (HHIP) represses airway remodeling and metabolic reprogramming in COPD-derived airway smooth muscle cells.
Li Y, Zhang L, Polverino F, Guo F, Hao Y, Lao T, Xu S, Li L, Pham B, Owen CA, Zhou X. Li Y, et al. Sci Rep. 2021 Apr 27;11(1):9074. doi: 10.1038/s41598-021-88434-x. Sci Rep. 2021. PMID: 33907231 Free PMC article.
Smooth muscle mass around airways was measured by immunofluorescence staining for alpha-smooth muscle actin (alpha-SMA) in lung sections from Hhip(+/-) mice and their wild type littermates, Hhip(+/+) mice. Airway remodeling was assessed in Hhip(+/-) and Hh …
Smooth muscle mass around airways was measured by immunofluorescence staining for alpha-smooth muscle actin (alpha-SMA) in lung sections fro …
Activation of CD8+ T Cells in Chronic Obstructive Pulmonary Disease Lung.
Villaseñor-Altamirano AB, Jain D, Jeong Y, Menon JA, Kamiya M, Haider H, Manandhar R, Sheikh MDA, Athar H, Merriam LT, Ryu MH, Sasaki T, Castaldi PJ, Rao DA, Sholl LM, Vivero M, Hersh CP, Zhou X, Veerkamp J, Yun JH, Kim EY; MassGeneralBrigham - Bayer Pulmonary Drug Discovery Laboratory. Villaseñor-Altamirano AB, et al. Am J Respir Crit Care Med. 2023 Dec 1;208(11):1177-1195. doi: 10.1164/rccm.202305-0924OC. Am J Respir Crit Care Med. 2023. PMID: 37756440
We validated in an independent patient cohort (N = 929) and integrated with the Hhip(+/-) murine model of COPD. Measurements and Main Results: Mild-moderate COPD lungs have increased abundance of two CD8(+) T cell subpopulations: cytotoxic KLRG1(+)TIGIT(+)CX3CR1(+) TEMRA ( …
We validated in an independent patient cohort (N = 929) and integrated with the Hhip(+/-) murine model of COPD. Measurements and Main …
LncRNA HHIP-AS1 suppresses lung squamous cell carcinoma by stabilizing HHIP mRNA.
Hu Z, Liu Y, Tang J, Luo R, Qin J, Mo Z, Xie J, Jiang X, Wei S, Lin C. Hu Z, et al. Life Sci. 2023 May 15;321:121578. doi: 10.1016/j.lfs.2023.121578. Epub 2023 Mar 21. Life Sci. 2023. PMID: 36958438
Transcriptome profiling of HHIP-AS1 knockdown (KD) cells uncovered HHIP downregulation. Interestingly, a comparison between the transcriptomes of HHIP-AS1 KD or HHIP KD cells manifested high similarity. Subsequently it's confirmed that HHIP-AS1 …
Transcriptome profiling of HHIP-AS1 knockdown (KD) cells uncovered HHIP downregulation. Interestingly, a comparison between th …
Hhip haploinsufficiency sensitizes mice to age-related emphysema.
Lao T, Jiang Z, Yun J, Qiu W, Guo F, Huang C, Mancini JD, Gupta K, Laucho-Contreras ME, Naing ZZ, Zhang L, Perrella MA, Owen CA, Silverman EK, Zhou X. Lao T, et al. Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4681-7. doi: 10.1073/pnas.1602342113. Epub 2016 Jul 21. Proc Natl Acad Sci U S A. 2016. PMID: 27444019 Free PMC article.
Herein, using Hhip heterozygous mice (Hhip(+/-)), we observed increased lung compliance and spontaneous emphysema in Hhip(+/-) mice starting at 10 mo of age. This increase was preceded by increases in oxidative stress levels in the lungs of Hhip(+/-) v …
Herein, using Hhip heterozygous mice (Hhip(+/-)), we observed increased lung compliance and spontaneous emphysema in Hhip …
Hedgehog Interacting Protein (Hhip) Regulates Insulin Secretion in Mice Fed High Fat Diets.
Nchienzia H, Liao MC, Zhao XP, Chang SY, Lo CS, Chenier I, Ingelfinger JR, Chan JSD, Zhang SL. Nchienzia H, et al. Sci Rep. 2019 Aug 1;9(1):11183. doi: 10.1038/s41598-019-47633-3. Sci Rep. 2019. PMID: 31371780 Free PMC article.
Here, we investigate the role of Hhip in modulating insulin secretion in adult Hhip mice (Hhip +/- vs. Hhip+/+) fed high fat diets (HFD). Both sexes of HFD-Hhip +/+ mice developed impaired glucose intolerance, that was only ameliorated in male H …
Here, we investigate the role of Hhip in modulating insulin secretion in adult Hhip mice (Hhip +/- vs. Hhip+/+) …
306 results