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1988 1
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943 results

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The following term was not found in PubMed: ENSG00000105327
Page 1
A novel compound EPIC-0412 reverses temozolomide resistance via inhibiting DNA repair/MGMT in glioblastoma.
Zhao J, Yang S, Cui X, Wang Q, Yang E, Tong F, Hong B, Xiao M, Xin L, Xu C, Tan Y, Kang C. Zhao J, et al. Neuro Oncol. 2023 May 4;25(5):857-870. doi: 10.1093/neuonc/noac242. Neuro Oncol. 2023. PMID: 36272139 Free PMC article.
RESULTS: EPIC-0412 physically interrupts the binding of HOTAIR and EZH2, leading to the upregulation of CDKN1A and BBC3, causing cell cycle arrest and apoptosis in GBM cells. EPIC-0412 inhibits DNA damage response in GBM cells through the p21-E2F1 DNA damage repair axis. . …
RESULTS: EPIC-0412 physically interrupts the binding of HOTAIR and EZH2, leading to the upregulation of CDKN1A and BBC3, causing cell …
AHR-mediated m6A RNA methylation contributes to PM2.5-induced cardiac malformations in zebrafish larvae.
Ji C, Tao Y, Li X, Wang J, Chen J, Aniagu S, Jiang Y, Chen T. Ji C, et al. J Hazard Mater. 2023 Sep 5;457:131749. doi: 10.1016/j.jhazmat.2023.131749. Epub 2023 Jun 2. J Hazard Mater. 2023. PMID: 37270964
In addition, we found that the expression levels of traf4a and bbc3, two apoptosis related genes, were upregulated by EOM but restored to control levels by the forced expression of mettl14. Moreover, knockdown of either traf4a or bbc3 attenuated EOM-induced ROS over …
In addition, we found that the expression levels of traf4a and bbc3, two apoptosis related genes, were upregulated by EOM but restore …
Role of miR-139-5p in ectopic endometrial stromal cells and the underlying molecular mechanism.
Feng L, Chen X, Zhang S, Chen Y, Yu Y. Feng L, et al. Exp Ther Med. 2021 Nov;22(5):1251. doi: 10.3892/etm.2021.10686. Epub 2021 Sep 2. Exp Ther Med. 2021. PMID: 34539847 Free PMC article.
Both transfection with the miR-139-5p inhibitor and BBC3-small interfering (si)RNA markedly downregulated miR-139-5p and BBC3 expression levels in ectopic ESCs, respectively. miR-139-5p inhibitor-induced upregulated BBC3 expression was reversed following tran …
Both transfection with the miR-139-5p inhibitor and BBC3-small interfering (si)RNA markedly downregulated miR-139-5p and BBC3 …
Anti-apoptotic capacity of Mcl-1Δ127.
Wang Y, Su W, Mai Z, Yu S, Wang X, Chen T. Wang Y, et al. Biochem Biophys Res Commun. 2020 Jun 11;526(4):1042-1048. doi: 10.1016/j.bbrc.2020.03.181. Epub 2020 Apr 21. Biochem Biophys Res Commun. 2020. PMID: 32331834
Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA.
Xie W, Zhang L, Jiao H, Guan L, Zha J, Li X, Wu M, Wang Z, Han J, You H. Xie W, et al. Autophagy. 2015;11(9):1623-35. doi: 10.1080/15548627.2015.1075688. Autophagy. 2015. PMID: 26212789 Free PMC article.
Inhibition of CMA results in stabilization of BBC3, which in turn sensitizes tumor cells to undergo apoptosis. ...Mechanistically, Ser10 phosphorylation facilitates BBC3 translocation from the cytosol to mitochondria. BBC3 stabilization resulting from either …
Inhibition of CMA results in stabilization of BBC3, which in turn sensitizes tumor cells to undergo apoptosis. ...Mechanistically, Se …
BBC3 in macrophages promoted pulmonary fibrosis development through inducing autophagy during silicosis.
Liu H, Cheng Y, Yang J, Wang W, Fang S, Zhang W, Han B, Zhou Z, Yao H, Chao J, Liao H. Liu H, et al. Cell Death Dis. 2017 Mar 9;8(3):e2657. doi: 10.1038/cddis.2017.78. Cell Death Dis. 2017. PMID: 28277537 Free PMC article.
Here, we exposed U937 cell-derived macrophages (UDMs) to SiO(2) in vitro to explore the function of BBC3 in SiO(2)-induced disease. We found that SiO(2) induced increased BBC3 expression, as well as macrophage activation and apoptosis. Knockdown of Bbc3 with …
Here, we exposed U937 cell-derived macrophages (UDMs) to SiO(2) in vitro to explore the function of BBC3 in SiO(2)-induced disease. W …
BIM's up first.
Murphy DJ, Muthalagu N. Murphy DJ, et al. Mol Cell Oncol. 2014 Dec 1;2(2):e975083. doi: 10.4161/23723556.2014.975083. eCollection 2015 Apr-Jun. Mol Cell Oncol. 2014. PMID: 27308426 Free PMC article.
Surprisingly, apoptosis induced by Myc in multiple solid tissues does not require p19Arf (Cdkn2a), whereas Puma (Bbc3) is required only in the context of sensitization by Myc to death induced by DNA damage....
Surprisingly, apoptosis induced by Myc in multiple solid tissues does not require p19Arf (Cdkn2a), whereas Puma (Bbc3) is required on …
Involvement of a proapoptotic gene (BBC3) in islet injury mediated by cold preservation and rewarming.
Omori K, Kobayashi E, Komatsu H, Rawson J, Agrawal G, Parimi M, Oancea AR, Valiente L, Ferreri K, Al-Abdullah IH, Kandeel F, Takahashi M, Mullen Y. Omori K, et al. Am J Physiol Endocrinol Metab. 2016 Jun 1;310(11):E1016-26. doi: 10.1152/ajpendo.00441.2015. Epub 2016 Apr 26. Am J Physiol Endocrinol Metab. 2016. PMID: 27117005 Free PMC article.
Cold preservation-mediated islet injury occurred during rewarming in "Firefly" islets. Silencing Bbc3 by transfecting Bbc3 siRNA into islets in vitro prior to cold preservation improved postpreservation mitochondrial viability. ...These results demonstrated the invo …
Cold preservation-mediated islet injury occurred during rewarming in "Firefly" islets. Silencing Bbc3 by transfecting Bbc3 siR …
Mutated beta-catenin evades a microRNA-dependent regulatory loop.
Veronese A, Visone R, Consiglio J, Acunzo M, Lupini L, Kim T, Ferracin M, Lovat F, Miotto E, Balatti V, D'Abundo L, Gramantieri L, Bolondi L, Pekarsky Y, Perrotti D, Negrini M, Croce CM. Veronese A, et al. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4840-5. doi: 10.1073/pnas.1101734108. Epub 2011 Mar 7. Proc Natl Acad Sci U S A. 2011. PMID: 21383185 Free PMC article.
We have previously shown oncogenic features of miR-483-3p through cooperation with IGF2 or by independently targeting the proapoptotic gene BBC3/PUMA. Here we demonstrate that expression of miR-483 can be induced independently of IGF2 by the oncoprotein beta-catenin throug …
We have previously shown oncogenic features of miR-483-3p through cooperation with IGF2 or by independently targeting the proapoptotic gene …
Idasanutlin and navitoclax induce synergistic apoptotic cell death in T-cell acute lymphoblastic leukemia.
Johansson KB, Zimmerman MS, Dmytrenko IV, Gao F, Link DC. Johansson KB, et al. Leukemia. 2023 Dec;37(12):2356-2366. doi: 10.1038/s41375-023-02057-x. Epub 2023 Oct 14. Leukemia. 2023. PMID: 37838759 Free PMC article.
Treatment with idasanutlin, an MDM2 inhibitor, induced only modest apoptosis in T-ALL cells but upregulated the pro-apoptotic BH3 domain genes BAX and BBC3, prompting us to evaluate the combination of idasanutlin with BH3 mimetics. ...
Treatment with idasanutlin, an MDM2 inhibitor, induced only modest apoptosis in T-ALL cells but upregulated the pro-apoptotic BH3 domain gen …
943 results