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The following term was not found in PubMed: ENSG00000103449
Page 1
Townes-Brocks Syndrome.
Kohlhase J. Kohlhase J. 2007 Jan 24 [updated 2016 Jan 14]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2007 Jan 24 [updated 2016 Jan 14]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301618 Free Books & Documents. Review.
DIAGNOSIS/TESTING: The diagnosis of TBS is based on clinical findings; identification of a heterozygous SALL1 pathogenic variant on molecular genetic testing establishes the diagnosis if clinical features are inconclusive. ...The proportion of cases caused by de novo patho …
DIAGNOSIS/TESTING: The diagnosis of TBS is based on clinical findings; identification of a heterozygous SALL1 pathogenic variant on m …
Nephron organoids derived from human pluripotent stem cells model kidney development and injury.
Morizane R, Lam AQ, Freedman BS, Kishi S, Valerius MT, Bonventre JV. Morizane R, et al. Nat Biotechnol. 2015 Nov;33(11):1193-200. doi: 10.1038/nbt.3392. Nat Biotechnol. 2015. PMID: 26458176 Free PMC article.
By recapitulating metanephric kidney development in vitro, we generate SIX2+ SALL1+ WT1+ PAX2+ NPCs with 90% efficiency within 9 days of differentiation. ...
By recapitulating metanephric kidney development in vitro, we generate SIX2+ SALL1+ WT1+ PAX2+ NPCs with 90% efficiency within 9 days …
Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation.
Wang J, Xie W, Li N, Li W, Zhang Z, Fan N, Ouyang Z, Zhao Y, Lai C, Li H, Chen M, Quan L, Li Y, Jiang Y, Jia W, Fu L, Mazid MA, Zhu Y, Maxwell PH, Pan G, Esteban MA, Dai Z, Lai L. Wang J, et al. Cell Stem Cell. 2023 Sep 7;30(9):1235-1245.e6. doi: 10.1016/j.stem.2023.08.003. Cell Stem Cell. 2023. PMID: 37683604
The resulting cells had substantially enhanced viability in the xeno-environment of interspecies chimeric blastocyst and successfully formed organized human-pig chimeric middle-stage kidney (mesonephros) structures up to embryonic day 28 inside nephric-defective pig embryos lacki …
The resulting cells had substantially enhanced viability in the xeno-environment of interspecies chimeric blastocyst and successfully formed …
Monocytes promote acute neuroinflammation and become pathological microglia in neonatal hypoxic-ischemic brain injury.
Chen HR, Chen CW, Kuo YM, Chen B, Kuan IS, Huang H, Lee J, Anthony N, Kuan CY, Sun YY. Chen HR, et al. Theranostics. 2022 Jan 1;12(2):512-529. doi: 10.7150/thno.64033. eCollection 2022. Theranostics. 2022. PMID: 34976198 Free PMC article.
The CCR2-CreER-based fate-mapping showed that CCR2(+) monocytes became CD68(+) TNFalpha(+) macrophages within 4 d after LPS/HI, and maintained as TNFalpha(+) MHCII(+) macrophages or persisted as Tmem119(+) Sall1(+) P2RY12(+) ramified microglia for at least five months afte …
The CCR2-CreER-based fate-mapping showed that CCR2(+) monocytes became CD68(+) TNFalpha(+) macrophages within 4 d after LPS/HI, and maintain …
A Binary Cre Transgenic Approach Dissects Microglia and CNS Border-Associated Macrophages.
Kim JS, Kolesnikov M, Peled-Hajaj S, Scheyltjens I, Xia Y, Trzebanski S, Haimon Z, Shemer A, Lubart A, Van Hove H, Chappell-Maor L, Boura-Halfon S, Movahedi K, Blinder P, Jung S. Kim JS, et al. Immunity. 2021 Jan 12;54(1):176-190.e7. doi: 10.1016/j.immuni.2020.11.007. Epub 2020 Dec 16. Immunity. 2021. PMID: 33333014 Free article.
Focusing on macrophages in the brain, we establish here a binary transgenic system involving complementation-competent NCre and CCre fragments whose expression is driven by distinct promoters: Sall1(ncre): Cx(3)cr1(ccre) mice specifically target parenchymal microglia and c …
Focusing on macrophages in the brain, we establish here a binary transgenic system involving complementation-competent NCre and CCre fragmen …
SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity.
Fixsen BR, Han CZ, Zhou Y, Spann NJ, Saisan P, Shen Z, Balak C, Sakai M, Cobo I, Holtman IR, Warden AS, Ramirez G, Collier JG, Pasillas MP, Yu M, Hu R, Li B, Belhocine S, Gosselin D, Coufal NG, Ren B, Glass CK. Fixsen BR, et al. Nat Immunol. 2023 Jul;24(7):1188-1199. doi: 10.1038/s41590-023-01528-8. Epub 2023 Jun 15. Nat Immunol. 2023. PMID: 37322178 Free PMC article.
Here we demonstrate that disruption of a conserved microglia-specific super-enhancer interacting with the Sall1 promoter results in complete and specific loss of Sall1 expression in microglia. By determining the genomic binding sites of SALL1 and leveraging …
Here we demonstrate that disruption of a conserved microglia-specific super-enhancer interacting with the Sall1 promoter results in c …
Re-expression of Sall1 in podocytes protects against adriamycin-induced nephrosis.
Hosoe-Nagai Y, Hidaka T, Sonoda A, Sasaki Y, Yamamoto-Nonaka K, Seki T, Asao R, Tanaka E, Trejo JAO, Kodama F, Takagi M, Tada N, Ueno T, Nishinakamura R, Tomino Y, Asanuma K. Hosoe-Nagai Y, et al. Lab Invest. 2017 Nov;97(11):1306-1320. doi: 10.1038/labinvest.2017.69. Epub 2017 Jul 31. Lab Invest. 2017. PMID: 28759006 Free article.
The highly conserved spalt (sal) gene family members encode proteins characterized by multiple double zinc finger motifs of the C2H2 type. Humans and mice each have four known Sal-like genes (SALL1-4 in humans and Sall1-4 in mice). Sall1 is known to have a cr …
The highly conserved spalt (sal) gene family members encode proteins characterized by multiple double zinc finger motifs of the C2H2 type. H …
Identification of proximal SUMO-dependent interactors using SUMO-ID.
Barroso-Gomila O, Trulsson F, Muratore V, Canosa I, Merino-Cacho L, Cortazar AR, Pérez C, Azkargorta M, Iloro I, Carracedo A, Aransay AM, Elortza F, Mayor U, Vertegaal ACO, Barrio R, Sutherland JD. Barroso-Gomila O, et al. Nat Commun. 2021 Nov 18;12(1):6671. doi: 10.1038/s41467-021-26807-6. Nat Commun. 2021. PMID: 34795231 Free PMC article.
Likewise, SUMO-ID also allow us to identify interactors of SUMOylated SALL1, a less characterized SUMO substrate. Furthermore, using TP53 as a substrate, we identify SUMO1, SUMO2 and Ubiquitin preferential interactors. ...
Likewise, SUMO-ID also allow us to identify interactors of SUMOylated SALL1, a less characterized SUMO substrate. Furthermore, using …
SALL1 promotes proliferation and metastasis and activates phosphorylation of p65 and JUN in colorectal cancer cells.
Yuan J, Li G, Zhong F, Liao J, Zeng Z, Ouyang S, Xie H, Deng Z, Tang H, Ou X. Yuan J, et al. Pathol Res Pract. 2023 Oct;250:154827. doi: 10.1016/j.prp.2023.154827. Epub 2023 Sep 20. Pathol Res Pract. 2023. PMID: 37741137
METHODS: Firstly, methylation differential gene SALL1 in CRC was screened and validated. SALL1 overexpression plasmids or SALL1 siRNAs were transfected in HT-29 and SW480 cells. ...Overexpression of SALL1 accelerated proliferation, migration and invasi …
METHODS: Firstly, methylation differential gene SALL1 in CRC was screened and validated. SALL1 overexpression plasmids or S …
Identification and characterization of Sall1-expressing cells present in the adult mouse kidney.
Abedin MJ, Imai N, Rosenberg ME, Gupta S. Abedin MJ, et al. Nephron Exp Nephrol. 2011;119(4):e75-82. doi: 10.1159/000328925. Epub 2011 Sep 20. Nephron Exp Nephrol. 2011. PMID: 21934330 Free article.
Following IRI, 90% of Sall1-expressing cells proliferated and 5% of Sall1-positive cells showed asymmetrical cell division with one of the two adjacent Sall1-positive cells incorporating chlorodeoxyuridine (CldU). ...Sall1-expressing cells proliferate …
Following IRI, 90% of Sall1-expressing cells proliferated and 5% of Sall1-positive cells showed asymmetrical cell division wit …
320 results