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The following term was not found in PubMed: ENSG00000036672
Page 1
Ubiquitin-Specific Proteases (USPs) and Metabolic Disorders.
Kitamura H. Kitamura H. Int J Mol Sci. 2023 Feb 6;24(4):3219. doi: 10.3390/ijms24043219. Int J Mol Sci. 2023. PMID: 36834633 Free PMC article. Review.
To date, accumulating evidence indicates that several USPs positively and negatively affect metabolic diseases. USP22 in pancreatic beta-cells, USP2 in adipose tissue macrophages, USP9X, 20, and 33 in myocytes, USP4, 7, 10, and 18 in hepatocytes, and USP2 in hypotha …
To date, accumulating evidence indicates that several USPs positively and negatively affect metabolic diseases. USP22 in pancreatic beta-cel …
USP2 promotes tumor immune evasion via deubiquitination and stabilization of PD-L1.
Kuang Z, Liu X, Zhang N, Dong J, Sun C, Yin M, Wang Y, Liu L, Xiao D, Zhou X, Feng Y, Song D, Deng H. Kuang Z, et al. Cell Death Differ. 2023 Oct;30(10):2249-2264. doi: 10.1038/s41418-023-01219-9. Epub 2023 Sep 5. Cell Death Differ. 2023. PMID: 37670038
USP2-depletion combination with anti-PD-1 also exhibits a synergistic anti-tumor effect. Furthermore, analysis of clinical tissue samples indicates that USP2 is positively associated with PD-L1 expression in cancer. Collectively, our data reveal a crucial role of …
USP2-depletion combination with anti-PD-1 also exhibits a synergistic anti-tumor effect. Furthermore, analysis of clinical tissue sam …
Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression.
Xiao W, Wang J, Wang X, Cai S, Guo Y, Ye L, Li D, Hu A, Jin S, Yuan B, Zhou Y, Li Q, Tong Q, Zheng L. Xiao W, et al. Autophagy. 2022 Nov;18(11):2615-2635. doi: 10.1080/15548627.2022.2044651. Epub 2022 Mar 6. Autophagy. 2022. PMID: 35253629 Free PMC article.
Rescue experiments revealed that USP2 harbored oncogenic properties via E2F4-facilitated autophagy and zinc homeostasis. Emetine, a small chemical inhibitor of autophagy, was able to block interaction between UPS2 and E2F4, increase labile intracellular zinc ions, and supp …
Rescue experiments revealed that USP2 harbored oncogenic properties via E2F4-facilitated autophagy and zinc homeostasis. Emetine, a s …
Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy.
Yi J, Tavana O, Li H, Wang D, Baer RJ, Gu W. Yi J, et al. Nat Commun. 2023 Apr 6;14(1):1941. doi: 10.1038/s41467-023-37617-3. Nat Commun. 2023. PMID: 37024504 Free PMC article.
Like Mdm2, VPRBP is a potent repressor of p53 but VPRBP stability is controlled by USP2. Interestingly, the USP2-VPRBP axis also regulates PD-L1 (programmed death-ligand 1) expression. ...In contrast to Mdm2, knockout of Usp2 in mice has no obvious effect in …
Like Mdm2, VPRBP is a potent repressor of p53 but VPRBP stability is controlled by USP2. Interestingly, the USP2-VPRBP axis al …
USP2-Related Cellular Signaling and Consequent Pathophysiological Outcomes.
Kitamura H, Hashimoto M. Kitamura H, et al. Int J Mol Sci. 2021 Jan 26;22(3):1209. doi: 10.3390/ijms22031209. Int J Mol Sci. 2021. PMID: 33530560 Free PMC article. Review.
Usp2 knockout mice exhibit changes in locomotion and male fertility, which suggest roles for USP2 in the central nervous system and male genital tract, respectively. In this review, we summarize the cellular events with USP2 contributions and list the signali …
Usp2 knockout mice exhibit changes in locomotion and male fertility, which suggest roles for USP2 in the central nervous syste …
Loss of deubiquitylase USP2 triggers development of glioblastoma via TGF-beta signaling.
Tu Y, Xu L, Xu J, Bao Z, Tian W, Ye Y, Sun G, Miao Z, Chao H, You Y, Liu N, Ji J. Tu Y, et al. Oncogene. 2022 Apr;41(18):2597-2608. doi: 10.1038/s41388-022-02275-0. Epub 2022 Mar 25. Oncogene. 2022. PMID: 35332268
USP2 was lost in GBM, leading to the poor prognosis in patients. ...In contrast, overexpressed USP2 suppressed TGF-beta signaling and GBM development. Specifically, USP2 interacted with SMAD7 and prevented SMAD7 ubiquitination. ...
USP2 was lost in GBM, leading to the poor prognosis in patients. ...In contrast, overexpressed USP2 suppressed TGF-beta signal …
The Molecular Mechanisms of Regulation on USP2's Alternative Splicing and the Significance of Its Products.
Zhu HQ, Gao FH. Zhu HQ, et al. Int J Biol Sci. 2017 Nov 2;13(12):1489-1496. doi: 10.7150/ijbs.21637. eCollection 2017. Int J Biol Sci. 2017. PMID: 29230097 Free PMC article. Review.
USP2 gene can generate 7 splicing variants through alternative splicing, and 5 variants respectively as USP2-201, USP2-202, USP2-204, USP2-205, USP2-206 can encode proteins. ...USP2-202 can activate apoptosis signaling pathway to p …
USP2 gene can generate 7 splicing variants through alternative splicing, and 5 variants respectively as USP2-201, USP2- …
USP2 promotes cell proliferation and metastasis in choroidal melanoma via stabilizing Snail.
Wei C, Zhao X, Zhang H, Wang L. Wei C, et al. J Cancer Res Clin Oncol. 2023 Sep;149(11):9263-9276. doi: 10.1007/s00432-023-04855-3. Epub 2023 May 18. J Cancer Res Clin Oncol. 2023. PMID: 37199836
This study aimed to determine the role of USP2 in CM and elucidate its molecular mechanisms. METHODS: MTT, Transwell, and wound-scratch assays were used to investigate the function of USP2 in the proliferation and metastasis of CM. ...A nude mouse model of CM was es …
This study aimed to determine the role of USP2 in CM and elucidate its molecular mechanisms. METHODS: MTT, Transwell, and wound-scrat …
USP2 is an SKP2 deubiquitylase that stabilizes both SKP2 and its substrates.
Zhang F, Zhao Y, Sun Y. Zhang F, et al. J Biol Chem. 2021 Oct;297(4):101109. doi: 10.1016/j.jbc.2021.101109. Epub 2021 Aug 21. J Biol Chem. 2021. PMID: 34425107 Free PMC article.
Unexpectedly, USP2-stabilized SKP2 did not destabilize its substrates p21 and p27. ...Biologically, growth suppression induced by USP2 knockdown or USP2 inhibitor is partially mediated via modulation of SKP2 and its substrates. ...
Unexpectedly, USP2-stabilized SKP2 did not destabilize its substrates p21 and p27. ...Biologically, growth suppression induced by …
Inhibition of USP2 Enhances TRAIL-Mediated Cancer Cell Death through Downregulation of Survivin.
Lee TG, Woo SM, Seo SU, Kim S, Park JW, Chang YC, Kwon TK. Lee TG, et al. Int J Mol Sci. 2023 Aug 15;24(16):12816. doi: 10.3390/ijms241612816. Int J Mol Sci. 2023. PMID: 37628997 Free PMC article.
Ubiquitin-specific protease 2 (USP2) is a deubiquitinase belonging to the USPs subfamily. USP2 has been known to display various biological effects including tumorigenesis and inflammation. ...Overexpression of survivin or USP2 significantly prevented apoptos …
Ubiquitin-specific protease 2 (USP2) is a deubiquitinase belonging to the USPs subfamily. USP2 has been known to display vario …
260 results