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Plasminogen activator inhibitor type 2 inhibits tumor necrosis factor alpha-induced apoptosis. Evidence for an alternate biological function.
Dickinson JL, Bates EJ, Ferrante A, Antalis TM. Dickinson JL, et al. J Biol Chem. 1995 Nov 17;270(46):27894-904. doi: 10.1074/jbc.270.46.27894. J Biol Chem. 1995. PMID: 7499264 Free article.
Plasminogen activator inhibitor type 2 (PAI-2) is a serine proteinase inhibitor or serpin that is a major product of macrophages in response to endotoxin and inflammatory cytokines. We have explored the role of PAI-2 in apop
Plasminogen activator inhibitor type 2 (PAI-2) is a serine proteinase inhibitor or serpin t
The C-D interhelical domain of the serpin plasminogen activator inhibitor-type 2 is required for protection from TNF-alpha induced apoptosis.
Dickinson JL, Norris BJ, Jensen PH, Antalis TM. Dickinson JL, et al. Cell Death Differ. 1998 Feb;5(2):163-71. doi: 10.1038/sj.cdd.4400324. Cell Death Differ. 1998. PMID: 10200461
The serine proteinase inhibitor (serpin), plasminogen activator inhibitor type 2 (PAI-2), has been reported to inhibit tumor necrosis factor-alpha (TNF) induced apoptosis. ...The PAI …
The serine proteinase inhibitor (serpin), plasminogen activator inhibitor type 2 (PAI-2), h …
CTSS Modulates Stress-Related Carotid Artery Thrombosis in a Mouse FeCl3 Model.
Xu S, Piao L, Wan Y, Huang Z, Meng X, Inoue A, Wang H, Yue X, Jin X, Shi GP, Kuzuya M, Cheng XW. Xu S, et al. Arterioscler Thromb Vasc Biol. 2023 Jul;43(7):e238-e253. doi: 10.1161/ATVBAHA.122.318455. Epub 2023 Apr 27. Arterioscler Thromb Vasc Biol. 2023. PMID: 37128920
BACKGROUND: Exposure to chronic psychological stress is a risk factor for metabolic cardiovascular disease. ...Compared to the nonstressed CTSS(+/+) mice, the stressed CTSS(-/-) mice had decreased levels of PAI-1, vWF, TNF (tumor necrosis factor
BACKGROUND: Exposure to chronic psychological stress is a risk factor for metabolic cardiovascular disease. ...Compared to the …
Molecular mechanisms governing tumor-necrosis-factor-mediated regulation of plasminogen-activator inhibitor type-2 gene expression.
Dear AE, Shen Y, Rüegg M, Medcalf RL. Dear AE, et al. Eur J Biochem. 1996 Oct 1;241(1):93-100. doi: 10.1111/j.1432-1033.1996.0093t.x. Eur J Biochem. 1996. PMID: 8898893 Free article.
Plasminogen-activator inhibitor type 2 (PAI-2), a serine protease inhibitor involved in the regulation of urokinase-dependent proteolysis, is also implicated in the inhibition of tumor-necrosis-factor-(T
Plasminogen-activator inhibitor type 2 (PAI-2), a serine protease inhibitor involved in the
Targeting spike protein-induced TLR/NET axis by COVID-19 therapeutic NRICM102 ameliorates pulmonary embolism and fibrosis.
Wei WC, Liaw CC, Tsai KC, Chiou CT, Tseng YH, Chiou WF, Lin YC, Tsai CI, Lin CS, Lin CS, Liou KT, Yu IS, Shen YC, Su YC. Wei WC, et al. Pharmacol Res. 2022 Oct;184:106424. doi: 10.1016/j.phrs.2022.106424. Epub 2022 Sep 5. Pharmacol Res. 2022. PMID: 36064077 Free PMC article.
NRICM102 was found to disrupt spike protein/ACE2 interaction, 3CL protease activity, reduce activation of neutrophils, monocytes and expression of cytokines (TNF-alpha, IL-1beta, IL-6, IL-8), chemokines (MCP-1, MIP-1, RANTES) and proinflammatory receptor (TLR4). NRICM102 also …
NRICM102 was found to disrupt spike protein/ACE2 interaction, 3CL protease activity, reduce activation of neutrophils, monocytes and express …
Brain-derived extracellular vesicles mediated coagulopathy, inflammation and apoptosis after sepsis.
Lin H, Chen H, Qi B, Jiang Y, Lian N, Zhuang X, Yu Y. Lin H, et al. Thromb Res. 2021 Nov;207:85-95. doi: 10.1016/j.thromres.2021.09.014. Epub 2021 Sep 23. Thromb Res. 2021. PMID: 34583153 Free article.
Enzyme-linked immunosorbent assay (ELISA) was used to measure the serum levels of plasminogen activator inhibitor type 1 (PAI-1), thrombin-antithrombin (TAT), D-dimer, fibrinogen(Fib), tumor necrosis factor-alpha (TNF-alpha) …
Enzyme-linked immunosorbent assay (ELISA) was used to measure the serum levels of plasminogen activator inhibitor ty
The serine proteinase inhibitor (serpin) plasminogen activation inhibitor type 2 protects against viral cytopathic effects by constitutive interferon alpha/beta priming.
Antalis TM, La Linn M, Donnan K, Mateo L, Gardner J, Dickinson JL, Buttigieg K, Suhrbier A. Antalis TM, et al. J Exp Med. 1998 Jun 1;187(11):1799-811. doi: 10.1084/jem.187.11.1799. J Exp Med. 1998. PMID: 9607921 Free PMC article.
The serine proteinase inhibitor (serpin) plasminogen activator inhibitor type 2 (PAI-2) is well characterized as an inhibitor of extracellular urokinase-type plasminogen activator. ...These observations, …
The serine proteinase inhibitor (serpin) plasminogen activator inhibitor type 2 (PAI-2) is …
Nuclear c-Myc plays an important role in the cytotoxicity of tumor necrosis factor alpha in tumor cells.
Jänicke RU, Lee FH, Porter AG. Jänicke RU, et al. Mol Cell Biol. 1994 Sep;14(9):5661-70. doi: 10.1128/mcb.14.9.5661-5670.1994. Mol Cell Biol. 1994. PMID: 8065303 Free PMC article.
The phosphoprotein c-Myc has the potential to kill cells by apoptosis. To investigate whether c-Myc is involved in tumor necrosis factor alpha (TNF-alpha)-mediated cell killing, we have examined two HeLa cell lines (D98 and H21) which show drama …
The phosphoprotein c-Myc has the potential to kill cells by apoptosis. To investigate whether c-Myc is involved in tumor ne
Suppression of PKC-alpha attenuates TNF-alpha-evoked cerebral barrier breakdown via regulations of MMP-2 and plasminogen-plasmin system.
Abdullah Z, Bayraktutan U. Abdullah Z, et al. Biochim Biophys Acta. 2016 Jul;1862(7):1354-66. doi: 10.1016/j.bbadis.2016.03.014. Epub 2016 Apr 17. Biochim Biophys Acta. 2016. PMID: 27094771 Free article.
Treatment of HBMEC with TNF-alpha significantly increased the mRNA and protein expressions of all plasminogen-plasmin system (PPS) components, namely tissue plasminogen activator, urokinase, urokinase plasminogen activator receptor and plasmi
Treatment of HBMEC with TNF-alpha significantly increased the mRNA and protein expressions of all plasminogen-plasmin system (PPS) co …
Crebanine, an aporphine alkaloid, sensitizes TNF-alpha-induced apoptosis and suppressed invasion of human lung adenocarcinoma cells A549 by blocking NF-kappaB-regulated gene products.
Yodkeeree S, Pompimon W, Limtrakul P. Yodkeeree S, et al. Tumour Biol. 2014 Sep;35(9):8615-24. doi: 10.1007/s13277-014-1998-6. Epub 2014 May 28. Tumour Biol. 2014. PMID: 24867094
In this study, we investigated the effects of crebanine on tumor necrosis factor alpha (TNF-alpha)-induced NF-kappaB activation and the expression of NF-kappaB-regulated gene products. ...Moreover, crebanine reduced TNF-alpha-induced A549 …
In this study, we investigated the effects of crebanine on tumor necrosis factor alpha (TNF-alpha)-induced
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