Abstract
1. The effects of GR203040, a tachykinin neurokinin1 receptor antagonist, on tissue damage induced by X-irradiation (Rad) or cisplatin (Cisp) were investigated in ferrets. 2. GR203040 (0.3 mg/kg SC) reduced the Rad-induced plasma protein extravasation (PPE) in the duodenum and kidney by 25% in each tissue. 3. GR203040 (3 mg/kg SC, 5-min pretreatment and every 8 hr for 48 hr after Cisp) reduced the Cisp-induced PPE in the duodenum, jejunum and lung by 59, 52 and 60%, respectively. 4. Histological examination showed that GR203040 also ameliorated the Rad- and Cisp-induced tissue damage.
MeSH terms
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Animals
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Antiemetics / pharmacology*
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Antineoplastic Agents / toxicity*
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Capillary Permeability / drug effects
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Capillary Permeability / radiation effects
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Cisplatin / toxicity*
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Duodenum / blood supply
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Duodenum / drug effects
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Duodenum / radiation effects
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Ferrets
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Histocytochemistry
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Jejunum / blood supply
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Jejunum / drug effects
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Jejunum / radiation effects
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Kidney / blood supply
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Kidney / drug effects
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Kidney / radiation effects
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Lung / blood supply
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Lung / drug effects
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Lung / radiation effects
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Male
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Neurokinin-1 Receptor Antagonists*
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Piperidines / pharmacology*
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Tetrazoles / pharmacology*
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Urinary Bladder / blood supply
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Urinary Bladder / drug effects
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Urinary Bladder / radiation effects
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Whole-Body Irradiation
Substances
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Antiemetics
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Antineoplastic Agents
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Neurokinin-1 Receptor Antagonists
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Piperidines
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Tetrazoles
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(2-methoxy-5-tetrazol-1-ylbenzyl)(2-phenylpiperidin-3-yl)amine
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Cisplatin