Abstract
The Microsponge Delivery System (MDS) is a unique technology for the controlled release of topical agents and consists of macroporous beads, typically 10-25 microns in diameter, loaded with active agent. When applied to the skin, the MDS releases its active ingredient on a time mode and also in response to other stimuli (rubbing, temperature, pH, etc). MDS technology is being used currently in cosmetics, over-the-counter (OTC) skin care, sunscreens and prescription products. By delivering the active gradually to the skin, MDS-benzoyl peroxide formulations, for example, have excellent efficacy with minimal irritation. These are typical benefits from the use of the MDS.
MeSH terms
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Acne Vulgaris / therapy
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Animals
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Benzoyl Peroxide / metabolism
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Benzoyl Peroxide / pharmacology
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Drug Carriers / chemistry
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Drug Carriers / metabolism
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Drug Carriers / therapeutic use
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Drug Compounding / methods*
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Drug Delivery Systems / methods*
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Humans
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Irritants / pharmacology
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Keratolytic Agents / pharmacology
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Menthol / metabolism
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Methylmethacrylates / metabolism
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Mice
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Microscopy, Electron, Scanning
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Microspheres*
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Nonoxynol / metabolism
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Permeability
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Polystyrenes / metabolism
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Rabbits
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Skin / metabolism
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Sunscreening Agents / metabolism
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Tretinoin / metabolism
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Tretinoin / pharmacology
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Vinyl Compounds / metabolism
Substances
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Drug Carriers
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Irritants
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Keratolytic Agents
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Methylmethacrylates
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Polystyrenes
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Sunscreening Agents
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Vinyl Compounds
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Menthol
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Nonoxynol
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Tretinoin
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divinyl benzene
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Benzoyl Peroxide