Estimation of infarct size using serum troponin T concentration in patients with acute myocardial infarction

Jpn Circ J. 1993 Nov;57(11):1062-70. doi: 10.1253/jcj.57.1062.

Abstract

To estimate the size of myocardial infarction, serum troponin T concentration was measured in 34 patients with acute myocardial infarction. Left ventriculography, 2-dimensional echocardiography and resting 201thallium myocardial single photon emission computed tomography (SPECT) were performed about 4 weeks after the onset of myocardial infarction and used for correlation with the late serum troponin T peak concentration which occurred on the 3rd to 5th day after onset. Both left ventricular ejection fraction (LVEF) obtained from left ventriculography and wall motion index (WMI) obtained from 2-dimensional echocardiography were inversely related to late troponin T peak value (LVEF: r = 0.68, p < 0.001, WMI: r = 0.70, p < 0.001). Extent score (ES) and severity score (SS), which were estimated from the initial resting 201thallium SPECT image, showed excellent linear correlations with late troponin T peak concentrations (ES: r = 0.77, p < 0.001, SS: r = 0.66, p < 0.001). This correlation was present both in patients with an early troponin T peak on day 1 (group A-16 patients) and in those without an early peak (group B-10 patients). Thus, late troponin T peak concentration can be used to predict infarct size regardless of the kinetics of its appearance in serum.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Echocardiography
  • Female
  • Heart / diagnostic imaging
  • Heart Ventricles / diagnostic imaging
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction / blood
  • Myocardial Infarction / diagnosis
  • Myocardial Infarction / pathology*
  • Radiography
  • Thallium Radioisotopes
  • Tomography, Emission-Computed, Single-Photon
  • Troponin / blood*
  • Troponin T

Substances

  • Thallium Radioisotopes
  • Troponin
  • Troponin T