Biopolymers from marine invertebrates. XIV. Antifungal property of Dolabellanin A, a putative self-defense molecule of the sea hare, Dolabella auricularia

R Iijima; J Kisugi; M Yamazaki

doi:10.1248/bpb.17.1144

Biopolymers from marine invertebrates. XIV. Antifungal property of Dolabellanin A, a putative self-defense molecule of the sea hare, Dolabella auricularia

Biol Pharm Bull. 1994 Aug;17(8):1144-6. doi: 10.1248/bpb.17.1144.

Authors

R Iijima¹, J Kisugi, M Yamazaki

Affiliation

¹ Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan.

PMID: 7820128
DOI: 10.1248/bpb.17.1144

Abstract

Dolabellanin A (DAA), the antineoplastic and antibacterial glycoprotein purified from the albumen gland of Dolabella auricularia, showed an antifungal activity. DAA suppressed fungal growth completely at a concentration of over 2 micrograms/ml, and the colony forming ability of the fungus was significantly decreased after contact with DAA. These results indicate that DAA is an antifungal protein and its mode of antifungal activity is fungicidal.

MeSH terms

Animals
Antifungal Agents / pharmacology*
Antineoplastic Agents / pharmacology*
Aplysia / metabolism*
Candida albicans / drug effects
Candida albicans / genetics
Glycoproteins / pharmacology*
Microbial Sensitivity Tests
Saccharomyces cerevisiae / drug effects
Saccharomyces cerevisiae / genetics
Schizosaccharomyces / drug effects
Schizosaccharomyces / genetics

Substances

Antifungal Agents
Antineoplastic Agents
Glycoproteins
dolabellanin A protein, Dolabella auricularia