[Effects of Paeonia-glycyrrhiza decoction on changes induced by cisplatin in rats]

Zhongguo Zhong Xi Yi Jie He Za Zhi. 1994 Nov;14(11):673-4.
[Article in Chinese]

Abstract

In order to study the effects of Paeonia-Glycyrrhiza decoction (PGD) on the changes induced by cisplatin in rats, platinum-wire bipolar electrodes were inserted into the serosal membrane of the small intestine and migrating myoelectric complex (MMC) was used as index. After intravenous injection of cisplatin at doses of 4 mg/kg, the duration of the MMC cycles was significantly shorter than that of normal MMC cycles (P < 0.05) while the duration of phase III was remarkably prolonged comparing with that of normal phase III (P < 0.01) with latent period of 53.2 +/- 20.4 minutes. Taking PGD orally, cisplatin no longer induced the changes of MMC. The results suggest that PGD has marked adjusting effects on the changes of MMC induced by cisplatin. This might be one of the causes of PGD in relieving diarrhea induced by cisplatin in rats.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Cisplatin / adverse effects*
  • Drugs, Chinese Herbal / pharmacology*
  • Glycyrrhiza*
  • Intestine, Small / physiopathology
  • Male
  • Muscle, Smooth / physiopathology
  • Myoelectric Complex, Migrating / drug effects*
  • Plants, Medicinal*
  • Rats
  • Rats, Wistar

Substances

  • Drugs, Chinese Herbal
  • Cisplatin