The results of an investigation of fatigue and pain in the locomotor system are presented. The investigation comprised a group of workers (n = 56) who spent most of their working hours at video display terminals (VDTs), and a control group (n = 39) of workers with a mainly free rhythm of work and insignificant physical strain. Fatigue and pain occurred more frequently in the muscles and joints of the workers working on VDT's (78.8:59%), although the differences did not reach statistical significance. On the basis of a rheumatological examination and earlier medical documentation a diagnosis of cervical syndrome was more frequently determined in the VDT group (23.2%) than in the control group (10.3%), while low back pain was diagnosed equally in both groups (17.5%). According to subjective estimation in 46.9% of VDT workers and in 17.9% of the controls disorders were associated with unsatisfactory work conditions. The need for relaxation exercises at the workplace and for the introduction of ergonomic principles for work with VDTs is discussed, particularly with regard to adaptation of the work chair, table, text-stand and foot-rest, and the need to respect anthropometric requirements and working hours. The benefit of movement and isometric exercises at the workplace is emphasized.