Abstract
The mutagenicity of N-nitrosomethamphetamine (NMA) and N-nitrosoephedrine (NEP), which were synthesized in our laboratory, was examined by the modified pre-incubation method of Ames assay using Salmonella typhimurium TA100 and TA98. Both nitroso compounds showed significant mutagenic activity in the presence of hamster S9.
MeSH terms
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Animals
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Cricetinae
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Methamphetamine / analogs & derivatives*
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Methamphetamine / toxicity
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Microsomes, Liver / drug effects
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Microsomes, Liver / metabolism
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Mutagenicity Tests
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Nitrosamines / toxicity*
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Rats
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Salmonella / drug effects
Substances
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Nitrosamines
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N-nitrosoephedrine
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Methamphetamine
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N-nitrosomethamphetamine