Mutagenic activity of N-nitrosomethamphetamine and N-nitrosoephedrine

Cancer Lett. 1983 Nov;21(1):63-8. doi: 10.1016/0304-3835(83)90083-6.

Abstract

The mutagenicity of N-nitrosomethamphetamine (NMA) and N-nitrosoephedrine (NEP), which were synthesized in our laboratory, was examined by the modified pre-incubation method of Ames assay using Salmonella typhimurium TA100 and TA98. Both nitroso compounds showed significant mutagenic activity in the presence of hamster S9.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Cricetinae
  • Methamphetamine / analogs & derivatives*
  • Methamphetamine / toxicity
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / metabolism
  • Mutagenicity Tests
  • Nitrosamines / toxicity*
  • Rats
  • Salmonella / drug effects

Substances

  • Nitrosamines
  • N-nitrosoephedrine
  • Methamphetamine
  • N-nitrosomethamphetamine