Abstract
Skin metastasis of malignant melanoma has been difficult to control by chemoimmunotherapy. We report a case of melanoma with marked reduction of multiple skin and lung metastasis and an improved cell-mediated immunity using combined DAV (DTIC, ACNU, Vincristine) and OK-432 chemoimmunotherapy in association with doses of indomethacin administered over a long period (250 mg/day, 6 months) to relieve the cancerous pain.
Publication types
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Case Reports
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Dacarbazine / administration & dosage
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Humans
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Indomethacin / administration & dosage
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Indomethacin / therapeutic use*
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Lung Neoplasms / drug therapy
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Lung Neoplasms / secondary*
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Male
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Melanoma / drug therapy*
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Melanoma / pathology
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Melanoma / secondary
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Nimustine
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Nitrosourea Compounds / administration & dosage
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Pain, Intractable / drug therapy
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Picibanil / administration & dosage
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Skin Neoplasms / drug therapy*
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Skin Neoplasms / pathology
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Skin Neoplasms / physiopathology
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Suppositories
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Vincristine / administration & dosage
Substances
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Nitrosourea Compounds
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Suppositories
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Nimustine
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Picibanil
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Vincristine
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Dacarbazine
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Indomethacin