[Control of multiple skin and lung metastasis of malignant melanoma by combined DAV and OK-432 chemoimmunotherapy in association with large-scale administration of indomethacin]

Gan To Kagaku Ryoho. 1984 Nov;11(11):2434-7.
[Article in Japanese]

Abstract

Skin metastasis of malignant melanoma has been difficult to control by chemoimmunotherapy. We report a case of melanoma with marked reduction of multiple skin and lung metastasis and an improved cell-mediated immunity using combined DAV (DTIC, ACNU, Vincristine) and OK-432 chemoimmunotherapy in association with doses of indomethacin administered over a long period (250 mg/day, 6 months) to relieve the cancerous pain.

Publication types

  • Case Reports
  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Dacarbazine / administration & dosage
  • Humans
  • Indomethacin / administration & dosage
  • Indomethacin / therapeutic use*
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / secondary*
  • Male
  • Melanoma / drug therapy*
  • Melanoma / pathology
  • Melanoma / secondary
  • Nimustine
  • Nitrosourea Compounds / administration & dosage
  • Pain, Intractable / drug therapy
  • Picibanil / administration & dosage
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / pathology
  • Skin Neoplasms / physiopathology
  • Suppositories
  • Vincristine / administration & dosage

Substances

  • Nitrosourea Compounds
  • Suppositories
  • Nimustine
  • Picibanil
  • Vincristine
  • Dacarbazine
  • Indomethacin

Supplementary concepts

  • DAV protocol