This study was carried out to search for possible association between some polymorphic systems including ABO, MNSs, Rh, Duffy, Kell, Kidd, haptoglobin (Hp) and red cell acid phosphatase (PHs), and the variables serum cholesterol, triglyceride, urate, haemoglobin and blood pressure, in two separate samples of the Australian white population. Allele frequencies of each of the gene marker systems were comparable to those obtained by other workers for Australian whites. There were significant departures from Hardy-Weinberg proportions for red cell acid phosphatase and MNSs systems in one of the samples, and a possible cause for this is discussed. No associations were found between levels of cholesterol, triglyceride, urate and haemoglobin and most of the gene markers in either of the samples. However, a relationship was demonstrated between systolic blood pressure and two polymorphic systems, MNSs and Hp in both populations, and between diastolic blood pressure and red cell acid phosphatase in one of the samples.