Old subependymal hemorrhage (SEH) and old subependymal necrosis (SEN) were found in 18 (23%) and 14 (19%) cases respectively out of a total of 78 prematurely born infants who survived more than 3 weeks. Most of the lesions were recognized in the region of th stria terminalis. A nonhemorrhagic infarct (SEN) might occur at the stria terminalis in the perinatal period of the premature infant, following focal ischemia or hypoxia, and on occasion predispose to the production of subependymal hemorrhage in impaired cerebral vascular autoregulation.