The authors have shown that in patients with hereditary hypercholesteremia the use of plasmapheresis (PA) and cascade plasma filtration (CPF) with a cell separator 2997 (IBM, USA) and Evaflux-4A filter (Japan) makes it possible to considerably decrease the concentration of lipoprotein atherogenic classes (by 43-59%). The data obtained suggest that the use of CPF permits the return of 70-75% of the body protein, a marked decrease in the amount of substitution protein solution to minimize the risk of infection and probable allergic reactions to foreign proteins.