Neutrophils as instigators of thrombosis: Beyond antimicrobial protection

J A Páramo

doi:10.1016/j.rce.2019.11.013

Neutrophils as instigators of thrombosis: Beyond antimicrobial protection

Rev Clin Esp. 2020 Dec;220(9):583-586. doi: 10.1016/j.rce.2019.11.013. Epub 2020 Feb 24.

[Article in English, Spanish]

Author

J A Páramo¹

Affiliation

¹ Servicio de Hematología, CUN. Laboratorio Aterotrombosis, CIMA. Universidad de Navarra, IdiSNA, CIBERCV, Pamplona, España. Electronic address: japaramo@unav.es.

PMID: 32107018
DOI: 10.1016/j.rce.2019.11.013

Abstract

When activated, neutrophils release structures (NETs) composed of DNA, histones and granular proteins that provide an ideal matrix for platelet activation and coagulation mechanisms, thereby contributing to the pathogenesis of thrombosis in venous and arterial territories, as well as cancer-associated thrombosis. NETs play a key role in immunothrombosis, a term that describes the relationship between the immune response and coagulation.

Keywords: Inflamación; Inflammation; Leucocitos; Leukocytes; NETs; Thrombosis; Trombosis.