Abstract
Peptide E (PE), an opioid peptide from adrenal medulla, is known to possess very low analgesic potency when injected intracerebroventricularly in mice. The present study showed that PE analgesia was increased by co-injection with protease inhibitors (bacitracin and bestatin).
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Analgesics / pharmacology*
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Animals
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Bacitracin / pharmacology
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Drug Synergism
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Endorphins / antagonists & inhibitors*
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Enkephalins*
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Injections, Intraventricular
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Leucine / analogs & derivatives
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Leucine / pharmacology
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Male
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Mice
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Peptides / pharmacology*
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Protease Inhibitors / pharmacology*
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beta-Endorphin
Substances
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Analgesics
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Endorphins
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Enkephalins
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Peptides
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Protease Inhibitors
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Bacitracin
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beta-Endorphin
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peptide E (adrenal medulla)
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Leucine
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ubenimex