[Neuromedin U expression related to the occurrence of laryngeal carcinoma and the regional lymph node metastasis]

Objective:Research Institute of OtolaryngologyHead and Neck Surgery, Renmin Hospital of Wuhan University Neuromedin U(NMU) plays important role in immune regulation in a variety of tissues and organs, and this study intends to explore the correlation between the local metastasis of laryngeal cancer and the expression of NMU.Method:A retrospective analysis was made on 240 cases of laryngeal carcinoma in our hospital. The expression of NMU was detected by immunohistochemistry. Microassay tissue(TMA) was used to further analyze the correlation of NMU protein expression with T, N and M stage in laryngeal carcinoma.Result:Cervical lymph node metastasis was present in 51.4% of 240 laryngeal carcinoma patients. The expression of NMU was significantly higher in the patients with local metastasis than those without metastasis. And along with tumor progression, NMU expression increased significantly.Conclusion:The expression of NMU in laryngeal carcinoma was significantly correlated with the metastasis of laryngeal carcinoma and TNM stage, which indicated that NMU may be involved in the development of laryngeal carcinoma metastasis.