Comparison of Optical Coherence Tomography Angiography and Laser Speckle Flowgraphy for the Diagnosis of Normal-Tension Glaucoma

Asuka Takeyama; Kyoko Ishida; Ayako Anraku; Masahiro Ishida; Goji Tomita

doi:10.1155/2018/1751857

Comparison of Optical Coherence Tomography Angiography and Laser Speckle Flowgraphy for the Diagnosis of Normal-Tension Glaucoma

J Ophthalmol. 2018 Jan 31:2018:1751857. doi: 10.1155/2018/1751857. eCollection 2018.

Authors

Asuka Takeyama^{1

2}, Kyoko Ishida², Ayako Anraku², Masahiro Ishida¹, Goji Tomita²

Affiliations

¹ Department of Ophthalmology, Teikyo University Hospital, Mizonokuchi, Kawasaki, Japan.
² Department of Ophthalmology, Toho University Ohashi Medical Center, Tokyo, Japan.

Abstract

Purpose: To compare optical coherence tomography angiography (OCT-A) and laser speckle flowgraphy (LSFG) for the diagnosis of normal-tension glaucoma (NTG).

Methods: Twenty-eight eyes of 28 patients with NTG and 25 eyes of 25 normal subjects matched for age, refractive errors, systemic blood pressure, and central corneal thickness were evaluated. OCT-A was used to measure whole image vessel density, inside disc vessel density, and peripapillary vessel density; using LSFG, mean blur rate (MBR) inside the whole optic nerve head (ONH) area (MBR_A), and MBR of the vessel area (MBR_V) and tissue area (MBR_T) inside the ONH, were determined. Receiver operating characteristic (ROC) curves and areas under the ROC (AUROC) were used to assess the diagnostic ability of each variable.

Results: The AUROC for OCT-A whole image vessel density (0.950) was significantly greater than that for OCT-A peripapillary vessel density (0.830) and for all LSFG parameters (MBR_A = 0.793, MBR_V = 0.601, and MBR_T = 0.61) (P < 0.001). The AUROC for OCT-A inside disc vessel density (0.931) was significantly greater than that for all LSFG parameters (P < 0.005).

Conclusions: OCT-A vessel density had a higher glaucoma diagnostic ability compared to all LSFG parameters in patients with NTG.