Amiodarone-induced Thyrotoxicosis with Cardiopulmonary Arrest

Intern Med. 2018 Jan 1;57(1):59-63. doi: 10.2169/internalmedicine.9177-17. Epub 2017 Oct 16.

Abstract

We describe a case of amiodarone-induced thyrotoxicosis (AIT) with cardiopulmonary arrest (CPA) in a 49-year-old woman. The patient had been treated with amiodarone for non-sustained ventricular tachycardia. Two weeks prior to her admission, she developed thyrotoxicosis and prednisolone (PSL, 30 mg daily) was administered with the continuation of amiodarone. However, she was admitted to our hospital for CPA. We performed total thyroidectomy to control her thyrotoxicosis and the pathological findings were consistent with type 2 AIT. She gradually improved and was discharged on day 84. This case demonstrates the importance of considering immediate total thyroidectomy for patients with uncontrollable AIT.

Keywords: amiodarone-induced thyrotoxicosis; cardiopulmonary arrest; hyperthyroxinemia; prednisolone; thyroidectomy.

Publication types

  • Case Reports

MeSH terms

  • Amiodarone / adverse effects*
  • Amiodarone / therapeutic use*
  • Anti-Arrhythmia Agents / adverse effects*
  • Anti-Arrhythmia Agents / therapeutic use*
  • Female
  • Heart Arrest / chemically induced*
  • Humans
  • Middle Aged
  • Tachycardia, Ventricular / drug therapy*
  • Thyroidectomy
  • Thyrotoxicosis / chemically induced*
  • Thyrotoxicosis / surgery*
  • Treatment Outcome

Substances

  • Anti-Arrhythmia Agents
  • Amiodarone