Fatal SV40-associated pneumonia and nephropathy following renal allotransplantation in rhesus macaque

J Med Primatol. 2018 Feb;47(1):81-84. doi: 10.1111/jmp.12285. Epub 2017 Jul 3.

Abstract

Recrudescence of latent and dormant viruses may lead to overwhelming viremia in immunosuppressed hosts. In immunocompromised hosts, Simian virus 40 (SV40) reactivation is known to cause nephritis and demyelinating central nervous system disease. Here, we report SV40 viremia leading to fatal interstitial pneumonia in an immunosuppressed host following renal allotransplantation.

Keywords: SV40; opportunistic infection; renal transplant; rhesus macaque; viral reactivation.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Immunocompromised Host*
  • Kidney Diseases / physiopathology*
  • Kidney Diseases / virology
  • Kidney Transplantation / veterinary
  • Macaca mulatta*
  • Monkey Diseases / physiopathology*
  • Monkey Diseases / virology
  • Pneumonia / physiopathology*
  • Pneumonia / virology
  • Polyomavirus Infections / complications
  • Polyomavirus Infections / veterinary*
  • Simian virus 40 / physiology*
  • Tumor Virus Infections / complications
  • Tumor Virus Infections / veterinary*