The patients with mesofrontal epilepsy (ME) were under this study. Idiopathic atrophic events in the cerebral cortex are the major etiology factors. ME seizures develop as a sequence of epileptic discharges in the supplementary motor zone (SMZ) and have some characteristic features as tonic convulsions in one or both hands with concomitant adversive spells, short seizures with prompt after-seizure orientation and the proprioceptive afferent signals being capable of provoking the spells. Such peculiarities of ME manifestations depend on both structural-functional SMZ organization and the state of epileptic focus trigger channel. The whole brain functional state is also of major importance.