Severe Coagulation Disorder and Thrombocytopenia Associated with Tigecycline - Case Report and Review of Literature

Curr Drug Saf. 2017;12(1):7-9. doi: 10.2174/1574886311666160920090714.

Abstract

Herein, we report a 70-year-old male patient, with recurrent multiple hepatic abscesses, that was admitted to the internal medicine department for treatment of Carbapenem Resistant Escherichia Coli (CRE) bacteremia. The patient was treated with Tigecycline; few days later, he developed "Disseminated Intravascular Coagulation (DIC)" like coagulation study abnormality that seemed to be related to Tigecycline treatment. Upon discontinuing it, the DIC-like condition was resolved. Tigecycline should be considered as a possible etiological factor in patients with DIC-like, and this therapy should be withdrawn immediately in suspected cases.

Keywords: Coagulation disorder; DIC; Tigecycline; hypofibrinogenemia; thrombocytopenia.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Anti-Bacterial Agents / adverse effects*
  • Disseminated Intravascular Coagulation / chemically induced*
  • Disseminated Intravascular Coagulation / complications
  • Disseminated Intravascular Coagulation / diagnosis*
  • Humans
  • Male
  • Minocycline / adverse effects
  • Minocycline / analogs & derivatives*
  • Severity of Illness Index
  • Thrombocytopenia / chemically induced*
  • Thrombocytopenia / complications
  • Thrombocytopenia / diagnosis*
  • Tigecycline

Substances

  • Anti-Bacterial Agents
  • Tigecycline
  • Minocycline