Production of infectious HIV-1 particles requires viral envelope (Env) glycoprotein incorporation. Although, the precise mechanism remains elusive, interaction between Env and the matrix (MA) domain of Gag plays a central role. Work by Mu and colleagues demonstrates how the Env-MA interaction regulates gag mRNA stability and Gag expression levels.
Keywords: Envelope (Env); Gag; Genomic RNA; HIV-1; No-go mRNA decay; RuvB-like 2 (RVB-2).
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