No-Go'ing Back: Co-opting RVB-2 to Control HIV-1 Gene Expression and Immune Response

Trends Microbiol. 2015 Oct;23(10):593-595. doi: 10.1016/j.tim.2015.08.006. Epub 2015 Sep 2.

Abstract

Production of infectious HIV-1 particles requires viral envelope (Env) glycoprotein incorporation. Although, the precise mechanism remains elusive, interaction between Env and the matrix (MA) domain of Gag plays a central role. Work by Mu and colleagues demonstrates how the Env-MA interaction regulates gag mRNA stability and Gag expression levels.

Keywords: Envelope (Env); Gag; Genomic RNA; HIV-1; No-go mRNA decay; RuvB-like 2 (RVB-2).

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Carrier Proteins / metabolism*
  • DNA Helicases / metabolism*
  • Gene Expression Regulation, Viral*
  • HIV-1 / physiology*
  • Host-Pathogen Interactions*
  • Humans
  • env Gene Products, Human Immunodeficiency Virus / biosynthesis*
  • gag Gene Products, Human Immunodeficiency Virus / biosynthesis*

Substances

  • Carrier Proteins
  • env Gene Products, Human Immunodeficiency Virus
  • gag Gene Products, Human Immunodeficiency Virus
  • DNA Helicases