Effective treatment of delayed union of a lumbar vertebral fracture with daily administration of teriparatide in a patient with diffuse idiopathic skeletal hyperostosis

Eur Spine J. 2015 May:24 Suppl 4:S573-6. doi: 10.1007/s00586-014-3733-9. Epub 2015 Feb 4.

Abstract

Introduction: We herein describe a case of delayed union of a lumbar spine fracture in a 70-year-old patient with diffuse idiopathic skeletal hyperostosis (DISH).

Clinical course and result: Because he decided not to undergo surgical treatment, we provided conservative treatment with teriparatide (TPTD). Union was obtained in 2 months, and no adverse events were observed during treatment. Six months after starting the TPTD, further bone formation was observed and the lumbar instability had resolved.

Conclusion: This is the first report of successful use of TPTD to treat delayed union of a spine fracture in a patient with DISH without surgical intervention.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Bone Density Conservation Agents / therapeutic use*
  • Fractures, Ununited / diagnostic imaging
  • Fractures, Ununited / drug therapy*
  • Fractures, Ununited / physiopathology
  • Humans
  • Hyperostosis, Diffuse Idiopathic Skeletal / complications*
  • Male
  • Osteogenesis / drug effects
  • Spinal Fractures / diagnostic imaging
  • Spinal Fractures / drug therapy*
  • Spinal Fractures / etiology
  • Spinal Fractures / physiopathology
  • Teriparatide / therapeutic use*
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Bone Density Conservation Agents
  • Teriparatide