Biodegradable micelles capable of mannose-mediated targeted drug delivery to cancer cells

Macromol Rapid Commun. 2015 Mar;36(5):483-9. doi: 10.1002/marc.201400650. Epub 2015 Jan 23.

Abstract

A targeted micellar drug delivery system is developed from a biocompatible and biodegradable amphiphilic polyester, poly(Lac-OCA)-b-(poly(Tyr(alkynyl)-OCA)-g-mannose) (PLA-b-(PTA-g-mannose), that is synthesized via controlled ring-opening polymerization of O-carboxyanhydride (OCA) and highly efficient "Click" chemistry. Doxorubicin (DOX), a model lipophilic anticancer drug, can be effectively encapsulated into the micelles, and the mannose moiety allows active targeting of the micelles to cancer cells that specifically express mannose receptors, which thereafter enhances the anticancer efficiency of the drug. Comprised entirely of biodegradable and biocompatible polyesters, this micellar system demonstrates promising potentials for targeted drug delivery and cancer therapy.

Keywords: O-carbyxyanhydride; micelles; polyesters; ring-opening polymerization; targeted drug delivery.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / pharmacology
  • Carcinoma, Hepatocellular / drug therapy*
  • Cell Survival / drug effects
  • Click Chemistry
  • Doxorubicin / administration & dosage
  • Doxorubicin / pharmacology*
  • Drug Carriers*
  • Drug Delivery Systems*
  • Humans
  • Liver Neoplasms / drug therapy
  • Lung Neoplasms / drug therapy*
  • Mannose / chemistry*
  • Micelles*
  • Molecular Structure
  • Polymerization
  • Polymers / chemistry*
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Micelles
  • Polymers
  • Doxorubicin
  • Mannose