Improving outcomes in DCDD liver transplantation: there can only be strength in numbers

D S Goldberg; P L Abt

doi:10.1111/ajt.12697

Improving outcomes in DCDD liver transplantation: there can only be strength in numbers

Am J Transplant. 2014 May;14(5):1016-20. doi: 10.1111/ajt.12697. Epub 2014 Apr 8.

Authors

D S Goldberg¹, P L Abt

Affiliation

¹ Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, PA; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

PMID: 24712410
DOI: 10.1111/ajt.12697

Abstract

In the United States, liver transplantation using donation after circulatory determination of death (DCDD) donors is challenged by persistently inferior graft survival compared with donation after neurological death (DND), along with declining rates of liver transplantation relative to the total number of DCDD donors. Advances in adult-to-adult living donor liver transplantation graft survival temporally related to the Adult-to-Adult Living Donor Liver Transplantation Cohort Study consortium suggest that a similarly focused collaborative effort may serve to stimulate evolution within DCDD liver transplantation. Without a multi-center consortium to support innovative trials, the current state of DCDD liver transplantation is unlikely to progress.

Keywords: A2ALL; donor selection; ex vivo perfusion; living donor liver transplantation; warm ischemia.

MeSH terms

Adult
Death*
Donor Selection / methods*
Graft Survival / physiology*
Humans
Liver Transplantation*
Tissue and Organ Procurement / statistics & numerical data*