Formation of multilayered vesicles from water/organic-solvent (w/o) emulsions: theory and practice

C Pidgeon; A H Hunt; K Dittrich

doi:10.1023/A:1016316730560

Formation of multilayered vesicles from water/organic-solvent (w/o) emulsions: theory and practice

Pharm Res. 1986 Feb;3(1):23-34. doi: 10.1023/A:1016316730560.

Authors

C Pidgeon¹, A H Hunt, K Dittrich

Affiliation

¹ Eli Lilly Research Laboratories, Indianapolis, Indiana, 46285.

PMID: 24271353
DOI: 10.1023/A:1016316730560

Abstract

Multilayered liposome (MLV) formation from water/organic-solvent (W/O) emulsions was studied. A fundamental liposome population parameter, the E(ratio), was defined and used to estimate the bilayer number and water spacing in MLV liposomes. MLVs prepared from W/O emulsions have optimum drug entrapment at an emulsion-lipid/emulsion-water ratio of ∼0.33. Drug entrapment is typically 50 to 65% under these optimal conditions.