Grafting nitroxide radicals on nanodiamond surface using click chemistry

Ekaterina E Romanova; Rana Akiel; Franklin H Cho; Susumu Takahashi

doi:10.1021/jp403183x

Grafting nitroxide radicals on nanodiamond surface using click chemistry

J Phys Chem A. 2013 Nov 21;117(46):11933-9. doi: 10.1021/jp403183x. Epub 2013 Jun 20.

Authors

Ekaterina E Romanova¹, Rana Akiel, Franklin H Cho, Susumu Takahashi

Affiliation

¹ Department of Chemistry and ‡Department of Physics, University of Southern California , Los Angeles, California 90089, United States.

PMID: 24256191
DOI: 10.1021/jp403183x

Abstract

We demonstrate grafting of nitroxide radicals on the surface of nanodiamonds (NDs). The surface of NDs is functionalized by azide groups. Nitroxide radicals are covalently bonded using Cu(I)-catalyzed azide/alkyne-click chemistry approach. The reaction is confirmed by infrared spectroscopy. The grafting of nitroxides is also verified by studying the rotational correlational time using electron paramagnetic resonance (EPR) spectroscopy. EPR study estimates that a few hundreds (tens) of nitroxide radicals are grafted on the surface of NDs with 100 nm (25 nm) of the average diameter.