We report a paper analytical device (PAD) that is based on the SlipChip concept. This SlipPAD enables robust, high-throughput, multiplexed sensing while maintaining the extreme simplicity of paper-based analysis. The SlipPAD is comprised of two wax-patterned paper fluidic layers. By slipping one layer relative to the other, solutions wick simultaneously into a large array of sensing reservoirs or sequentially into a large array of channels to carry out homogeneous or heterogeneous assays, respectively. The applicability of the device to high-throughput multiplex chemical analysis is demonstrated by colorimetric and fluorescent assays.