The effect of alcohol on the stomach differs from that on other organs such as the liver or pancreas, on account of the long time of the contact of the ethanol with gastric mucosa which is directly exposed to damage. From the reason of hydrophil and lipophil properties ethanol quickly is being absorbed in the stomach. The gastric alcohol dehydrogenase (ADH) plays an important role in the "first pass metabolism" of ethanol (FPM). The stomach is metabolic barrier against of the ethanol and its metabolites but simultaneously alone is exposed to the influence of alcohol. Alcohol effects to the secretion of the gastric acid, the motor activity and defense mechanisms of stomach. Alcohol consumption results in a significant increase in the stomach morbidity